DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bun and Tsc22d2

DIOPT Version :9

Sequence 1:	NP_001036357.2	Gene:	bun / 34665	FlyBaseID:	FBgn0259176	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	NP_001074698.1	Gene:	Tsc22d2 / 72033	MGIID:	1919283	Length:	769	Species:	Mus musculus

Alignment Length:	1087	Identity:	251/1087 - (23%)
Similarity:	357/1087 - (32%)	Gaps:	381/1087 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 KTTSSFEITSVTVGHPKLNAAGDTGDESADDLDESHTDD-NSRITDLENETP---------SMSE 316
            |..|.|:|||||......:...||  ||.||.|||.|:| :|.|.|:...|.         |.||
Mouse     7 KKKSCFQITSVTTAQVATSITEDT--ESLDDPDESRTEDVSSEIFDVSRATDYGPEEVCERSSSE 69

  Fly   317 DTFSKEEVYYANNALSTN---------APVIPTSSQYGLVVVDPIAPSLGQTIQNVQVNVSDNII 372
            :|.:..........:|.|         |...|.:...|.|....:|.:|.||:.....:||
Mouse    70 ETLNNVGDAETPGTVSPNLILDGQLAAASAAPANGGGGGVSARSVAGALAQTLAAAAASVS---- 130

  Fly   373 NVVSGAVTPGGTKKKDDIKETQHRSERFKVVKIE--STEPFKRGRWMCMDYL----DHSSVGNGG 431
                   |||.:..... :.....|.||:|:|::  |.||::||||.||:|.    |.|.:...|
Mouse   131 -------TPGPSSATPS-QPPATCSSRFRVIKLDHGSGEPYRRGRWTCMEYYERDSDSSVLTRSG 187

  Fly   432 N--NNEKTGSSTSEAHA--ATTDG----------GAAGVGAGSEAPAHKTTQSMILPPTQKLNEN 482
            :  .:..|...|:|..:  ..|.|          ||.|:.:|:::.....:|   |||::|:::.
Mouse   188 DCIRHSNTLEQTAERDSGLGATGGSVVVVVASMQGAHGLDSGTDSSLTAVSQ---LPPSEKMSQP 249

  Fly   483 HLEANSTDANWNYAEQQQQQQQQQQQQQTIVGNALTKTLPVALRNVSRSSSVTRSPNATVEFLSP 547
            .|            .|.|.....|.|....||.|:..:          |:|:...|.|..   .|
Mouse   250 TL------------AQPQSFSVGQPQPPPPVGGAVAPS----------SASLPPFPGAAT---GP 289

  Fly   548 NLLAQQQQQQQQLFDSVNANAASSPNPAGD----PNNMDYARTAAMQLHQTLQQLKQREDAMDVP 608
            ..:. ...|..||..:|...|.  |.|.|.    |.|::.|:..|:...               |
Mouse   290 QPMT-AAVQPTQLQGAVAGGAL--PGPVGQGLPPPPNVNLAQPVALAAQ---------------P 336

  Fly   609 PGAGGYANYQNGGDSAVGAASNNNSAAAATGESQLSTSYVEQQQQQQQPLSPA-PLTPQAAPTFA 672
            ..|||.:..|............:......:|:|:....:|     ..||.||| ||:..|:.|.|
Mouse   337 GPAGGSSLSQQFAYPQPQIPPGHLLPMQPSGQSEYLPPHV-----ALQPPSPAQPLSTSASATSA 396

  Fly   673 AVAAGQSPNFQLEQQQQQQQATSQIDGIVPQPFNPQQQQQQTP------QQSTAQQAAAAANATS 731
            :.|     :|.|...|......:|:.|...||     .:...|      |.:..|.|..|..|..
Mouse   397 SAA-----SFPLGSGQSVSSLGAQMMGASAQP-----SEAVAPGPVPVGQAAPCQPAGVAPAALG 451

  Fly   732 AVTAPPPQQTSNTSNAAVTTGQGQTMPLLSHMTSYEQQQPNLGAAAAAAAAGGTAATSVA----A 792
            .|..|          .:..||.||..|:        |....:|.:....|..|...|.|.    .
Mouse   452 GVVQP----------GSGLTGVGQPQPV--------QPPQQMGGSGQLPAVPGGPHTVVPGVPNV 498

  Fly   793 PQAIPTLQLQSAPSTIADPQQLMVP--QQQQQQQHQEEQQQQPQQQQQPLPPANIASASANNSNL 855
            |.|:|...:.|.|:|......:..|  |.||...|....:.....||
Mouse   499 PAAVPVPSVPSVPTTSVTMPNVPAPLGQSQQLSSHTPVSRSSSVIQQ------------------ 545

  Fly   856 NLTNTNVVATGEATTNALTLTDEQATAALAAAFATGAAAAATGATSAAAATQQQIQQLQQQPNAE 920
                                        :.:..|.|..:|.|      :..|..:.|.|.|
Mouse   546 ----------------------------VGSPLAQGTHSAPT------SLPQSDLSQFQTQ---- 572

  Fly   921 SETESFITASNPGGNRKRAFSNPHIGGPNDPSFMHRLNPQLYYYNKSQSGRSSFCVDESLWPTNN 985
                                :.|.:|..:|
Mouse   573 --------------------TQPLVGQVDD----------------------------------- 582

  Fly   986 PNGAVSDTNLYMGSSTDEDYEEAIDQFSPTIYTTRSASRAIPIPNSAGSSPQHQMHHSQPRIAIG 1050
                                             ||..|.  |:|.:..|.........:|.:|..
Mouse   583 ---------------------------------TRRKSE--PLPQAPLSLIAESKPVVKPPVADA 612

  Fly  1051 INQMEGGGPTRSTGAFSASPSIYAYPHSPFYASSPETSFGSAAMPGHPAASSRISFSYDPAFQRL 1115
            :.     .|.:.|...|.:.|::                 |.|:|
Mouse   613 LT-----NPLQLTPMNSLATSVF-----------------SIAIP-------------------- 635

  Fly  1116 QVPNASGDRRPRSPLECASVFAAVAAAATCGDAAGGAADTVISSASGTSAVAIDNKIEQAMDLVK 1180
              .:...||.|      ::.|.......||.:     :.::..||||...|||||||||||||||
Mouse   636 --VDGDEDRNP------STAFYQAFHLNTCQE-----SKSLWDSASGGGVVAIDNKIEQAMDLVK 687

  Fly  1181 SHLMIAVREEVEVLKERISELMDKINKLELENSILKSNIPQETLQQLQLQLQLAAPPATPAIQAA 1245
            ||||.|||||||||||:|.||:::.:.||.||::|||....:.|.||            ||.||.
Mouse   688 SHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSNNDQLSQL------------PAQQAN 740

  Fly  1246 PAVQSVVAPAAAGQAVQQQAAGAVAVTGVATSPASAVVPTSIPNGSA 1292
            |           |...||||        :...|.....|...||.|:
Mouse   741 P-----------GSTSQQQA--------MIAQPPQPTQPPQQPNVSS 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bun	NP_001036357.2	TSC22	1176..1223	CDD:279505	30/46 (65%)
Tsc22d2	NP_001074698.1	TSC22	683..739	CDD:279505	35/67 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844864
Domainoid	1	1.000	99	1.000	Domainoid score	I7099
eggNOG	1	0.900	-	-		E1_KOG4797
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	174	1.000	Inparanoid score	I4069
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44335
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2903
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.780