DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bun and Tsc22d1

DIOPT Version :9

Sequence 1:	NP_001036357.2	Gene:	bun / 34665	FlyBaseID:	FBgn0259176	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	NP_001103382.1	Gene:	Tsc22d1 / 498545	RGDID:	3850	Length:	1050	Species:	Rattus norvegicus

Alignment Length:	1373	Identity:	335/1373 - (24%)
Similarity:	481/1373 - (35%)	Gaps:	458/1373 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PASSNAGPGNNPVRRNSMLTPSRGVTIGGTGGNIRKL----TKVS-SLTSNHHFAVCYPPSNIYQ 71
            |.|:.|......:....|..|:.....|..||:...|    |.|| :..|:..|.   |||::.|
  Rat     5 PESTAAAAAAADISARKMAHPAMFPRRGSGGGSASALSAAGTGVSGAAPSSEDFP---PPSSLLQ 66

  Fly    72 NSNNAGSNS-ALQRTTSESLRLNMMSR-------VAAG--------------ATPTTVSRA-SSN 113
            ....|.|:: ..|....:|  ||::|:       :|.|              .||..:|.: |||
  Rat    67 PPPPAASSTQGPQPPPPQS--LNLLSQAQLQGQPLAPGGTQMKKKSGFQITSVTPAQISASISSN 129

  Fly   114 SSLATSTST------SLAPKSSSSS----GGSNSTPQQQQQQLVSSNNSSSSSNNSFTKASSPNN 168
            :|:|..|.:      |.....|||.    ..|.:|...:.::     :||..:.|:|.:|.:|
  Rat   130 NSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPER-----SSSEETLNNFQEAETP-- 187

  Fly   169 NGARS--------------------VGGAATSAATGTTAAAGSHHHQPHHHHHHHHHHHQHHNHQ 213
             ||.|                    :.|.|             |.|..|||||.||.||.||.|.
  Rat   188 -GAVSPNQPHLPQPHLPHLPQQNVVINGNA-------------HPHHLHHHHHIHHGHHLHHGHH 238

  Fly   214 QQQQQQTSLSQGHASLTVAGGS----------ASAGGGGGG------GSGSSSGTAAG--GTNRK 260
            .......      ||.:|.||.          ::||...||      .:.||:|..|.  .:.|.
  Rat   239 HSSHAAV------ASTSVPGGPPPTSPVSRKLSTAGSSDGGVPVPPTSAVSSAGLPASVMTSIRA 297

  Fly   261 PKTTSSFEITSVTVGHPKLNAAGDTGDESADDLDESHTDDNSRITDLENETPSMSEDTFSKEEVY 325
            |.|..|..:.|||                     .::..:|..|..:...:|.::
  Rat   298 PSTPGSIGVNSVT---------------------GTNATNNVNIAAVGGFSPGVA---------- 331

  Fly   326 YANNALSTNAPVIPTSSQYGLVVVDPIAPSLGQTIQNVQVNV---------SDNIINVVSGAVTP 381
               |::..||  :..|...|:.             ..|.|||         |..::|..:| :|.
  Rat   332 ---NSVHPNA--VSISGGPGVT-------------SGVNVNVLSGMGNGTISSPVLNAAAG-ITV 377

  Fly   382 GGTKKKDDIKETQH-----RSERFKVVKIEST-EPFKRGRWMCMDYLDHSSVGNGGNNNEKTGSS 440
            |....:.  ::.|.     .:.||:|||::|| ||||:|||.|.::.:..:
  Rat   378 GVVSSQQ--QQPQQPPPTVNTSRFRVVKLDSTSEPFKKGRWTCTEFYEREN-------------- 426

  Fly   441 TSEAHAATTDGGAAGVGAGSEAPAHKTTQSMILPPTQKLNENHLEANSTDANWNYAEQQQQQQQQ 505
                    ...|..||.      .:|..:::...||        ||:|:
  Rat   427 --------AVPGPEGVA------INKVVETVKQTPT--------EASSS---------------- 453

  Fly   506 QQQQQTIVGNALTKTLPVALRNVSRSSSVTRSPNATVEFLSPNLLAQQQQQ-------------Q 557
              ::::..|::::.       :||..|..|.|..:. |..:|.::.||||.             |
  Rat   454 --ERESTSGSSVSS-------SVSTLSHYTESVGSG-EMGAPTVVVQQQQPLPPAPPGLQGVALQ 508

  Fly   558 QQLFDSVNANAASSPNPAGDPNNMDYARTAAMQLHQTLQQLKQREDAMDVPPGAGGYANYQNGGD 622
            |..|        |||.    |.::..::.:.:||.......:|:.:...||..|
  Rat   509 QLDF--------SSPG----PQSISQSQMSQVQLQPQELSFQQKPNLQPVPLQA----------- 550

  Fly   623 SAVGAASNNNSAAAATG--ESQLS----TSYVEQQQQQQQPLSPAPLTPQAAPTFAAVAAGQSPN 681
                      :.:||||  .|.::    ||.|.||........|....||.||.......|..|.
  Rat   551 ----------TMSAATGIQPSPVNVVGVTSAVGQQPSISSLAQPQLPYPQPAPPVQTPLPGAPPQ 605

  Fly   682 FQLEQQQQQQQATSQIDGIVPQPFNPQQQQQQTPQQSTAQQAAAAANATSAVTAPPPQQTSNTSN 746
             ||:..|||....:||     .|.:.|...|..|.:...||....|..:|.       |:|:|..
  Rat   606 -QLQYGQQQPMVPTQI-----APGHGQPATQNPPSEYAQQQPIFQAAMSSG-------QSSSTGT 657

  Fly   747 AA----VTTGQGQTMPLLSHMTSYEQQQPNLGAAAAAAAAGGTAATSVAAPQAIPTLQLQSAPST 807
            .|    |...||..:|:          ||   .|..|..||.|......||.|:.|:......::
  Rat   658 GASVIPVAQPQGIQLPV----------QP---TAVQAQPAGATGQPIGQAPTAVSTVPAGGQIAS 709

  Fly   808 IADPQQLMVPQQQQQQQHQEE----QQQQPQQQQQPLP-PANIASASANNSNLNLTNTNVVATGE 867
            |.  ||..:|...|....|..    ||..|...|..|| |..|.......|..:|....|:|
  Rat   710 IG--QQANIPTAVQPPSTQVTPSVVQQGAPPSSQVVLPAPTGIIHQGVQTSAPSLPQQLVIA--- 769

  Fly   868 ATTNALTLTDEQATAALAAAFATGAAAAATGATSAAAATQQQIQQLQQQPNAES-ETESFITASN 931
                      .|:|.........|..|.|.|..|....|...:      |:|.: ...|.::::.
  Rat   770 ----------PQSTMVAVPPQTQGVEAVAHGVVSHQLPTGSPL------PSASTISVTSQVSSAG 818

  Fly   932 PGGNRKRAFSNPHIGGPNDPSFMHRLNPQLYYYNKSQSGRSSFCVDESLWPTNNPNGAVSDTNLY 996
            |                                    ||.||.       |||    .|...|:.
  Rat   819 P------------------------------------SGMSSV-------PTN----LVPPQNIA 836

  Fly   997 MGSSTDE-DYEEAIDQFSPTIYTTRSASRAIPIPNSAGSSPQHQMHHSQPRIAIGINQMEGGGPT 1060
            ...:|.. ...:::.| ||.|.|..:...|..||.|:.......:..     ||| :|||   .|
  Rat   837 QPPATQNGSLVQSVSQ-SPLIATNINLPLAQQIPLSSTQFSTQSLAQ-----AIG-SQME---DT 891

  Fly  1061 RSTGAFSASPSIYAYPHSPFYASSPET----SFGSAAMPGHPAASSRISFSYDP-AFQRLQVPNA 1120
            |.             |..|.....|:|    |.|.:|:....::|...|.|..| ....|..|..
  Rat   892 RR-------------PAEPSSGGLPQTLSGDSGGVSAVSDGSSSSLAASASLFPLKVLPLTTPLV 943

  Fly  1121 SGDRRPRSPLECASVFAAVAAAATCGDAAGGAADTVISSASGTSAVAIDNKIEQAMDLVKSHLMI 1185
            .|:                                  ..:||.|.|||||||||||||||||||.
  Rat   944 DGE----------------------------------DESSGASVVAIDNKIEQAMDLVKSHLMY 974

  Fly  1186 AVREEVEVLKERISELMDKINKLELENSILKSNIPQETLQQLQLQLQLAAPPATPAIQAAPAVQS 1250
            |||||||||||:|.||::|.::||.||::||:....|.|.|.|.|||..:||||  .|.....|.
  Rat   975 AVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPAT--TQPQGTTQP 1037

  Fly  1251 VVAPAAAG 1258
            ...||:.|
  Rat  1038 PAQPASQG 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bun	NP_001036357.2	TSC22	1176..1223	CDD:279505	30/46 (65%)
Tsc22d1	NP_001103382.1	TSC22	965..1011	CDD:279505	30/45 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348329
Domainoid	1	1.000	70	1.000	Domainoid score	I9306
eggNOG	1	0.900	-	-		E1_KOG4797
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001302
OrthoInspector	1	1.000	-	-		otm46433
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.700