DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bun and tsc22d2

DIOPT Version :9

Sequence 1:	NP_001036357.2	Gene:	bun / 34665	FlyBaseID:	FBgn0259176	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	XP_009294776.1	Gene:	tsc22d2 / 378875	ZFINID:	ZDB-GENE-031001-12	Length:	577	Species:	Danio rerio

Alignment Length:	1064	Identity:	210/1064 - (19%)
Similarity:	294/1064 - (27%)	Gaps:	529/1064 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 KTTSSFEITSVTVGHPKLNAAGDTGD-ESADDLDESHTDDNSRITDLENETPSMSEDTFSKEEVY 325
            |..|.|:|||| |...::.|..:|.| ||.||     .||::|..|:            |..|:|
Zfish     7 KKKSCFQITSV-VTQSQVAANNNTEDTESLDD-----PDDSTRTEDV------------SSSEIY 53

  Fly   326 YANNALSTNAPVIPTSSQYGLVVVDPIAPSLGQTIQN-------VQVNVSDNIINVVSGAVTPGG 383
                .:|......|.:....| ..:|:......::|:       ||:|.|..    .:|.::|..
Zfish    54 ----DMSKGGDFEPEACDVSL-TDEPLHSEAETSVQDSSRNASAVQMNPSAR----AAGQMSPAS 109

  Fly   384 TKKKDDIKETQHR------------SERFKVVKIE--STEPFKRGRWMCMDYLDH-SSVGNGGNN 433
            ...:.....|.|.            |.||:|:|::  :.||||||||.|.::.:. :..|...:|
Zfish   110 VSAQTSTPNTAHTTSVSSSATVSTCSSRFRVIKLDHGTGEPFKRGRWTCTEFYERDTDAGRTVDN 174

  Fly   434 NEKTGSSTSEAHAATTDGGAAGVGAGSEAPAHKTTQSMILPPTQKLNENHLEANSTDANWNYAEQ 498
            .:.|.      |:...||.||.|...:..|                        .||:.:..|..
Zfish   175 VKHTD------HSVDKDGAAAHVSTLAADP------------------------HTDSGYISAPS 209

  Fly   499 QQQQQQQQQ----QQQTIVGNALTKTLPVALRNVSRSSSVTRSPNATVEFLSPNLLAQQQQQQQQ 559
            ....:.||.    ..|...|:|.:.::|
Zfish   210 NPPVELQQHPFGIAPQNPFGDAKSPSMP------------------------------------- 237

  Fly   560 LFDSVNANAASSPNP--AGDPNNMDYARTAAMQLHQTLQQLKQREDAMDVPPGAGGYANYQNGGD 622
                    :.:.|.|  ||.|            |.:.:|.|:
Zfish   238 --------STTQPQPFYAGKP------------LQKPVQVLQ----------------------- 259

  Fly   623 SAVGAASNNNSAAAATGESQLSTSYVEQQQQQQQPLSPAPLTPQAAPTFAAVAAGQSPNFQLEQQ 687
                               .|.|.|..|.|....|:......|...|    :..|.||
Zfish   260 -------------------TLVTDYRAQHQPPGSPVVSVATLPLVTP----LTQGPSP------- 294

  Fly   688 QQQQQATSQIDGIVPQPFNPQQQQQQTPQQSTAQQAAAAANATSAVTAPPPQQTSNTSNAAVTTG 752
                                    ..||       ||...:                     ..|
Zfish   295 ------------------------IMTP-------AAGGVH---------------------LLG 307

  Fly   753 QGQTMPLLSHMTSYEQQQPNLGAAAAAAA-----AGGTAATSVAAPQAIPTLQLQSAPSTIADPQ 812
            .|..:....|..     ||.:|..|.|.|     |...:.:|.|..|.:|.: :.||.:|   ||
Zfish   308 MGLPISQPEHAV-----QPGMGMVAQALAPLIQPAVTVSVSSHAGVQNVPVV-MSSASNT---PQ 363

  Fly   813 QLMVPQQQQQQQHQEEQQQQPQQQQQPLPPANIASASANNSNLNLTNTNVVATGEATTNALTLTD 877
            .  ||          :|...|||.|    |..:.|.|            ||..|
Zfish   364 S--VP----------KQNAAPQQNQ----PQGVPSGS------------VVGLG----------- 389

  Fly   878 EQATAALAAAFATGAAAAATGATSAAAATQQQIQQLQQQPNAESETESFITASNPGGNRKRAFSN 942
                                                     |:.....|
Zfish   390 -----------------------------------------AQMSLSGF---------------- 397

  Fly   943 PHIGGPNDPSFMHRLNPQLYYYNKSQSGRSSFCVDESLWPTNNPNGAVSDTNLYMGSSTDEDYEE 1007
                ||.|....   .|::.   :..||.       |:.|. ||.|.
Zfish   398 ----GPIDEGLR---KPEML---QQSSGL-------SIRPL-NPEGL------------------ 426

  Fly  1008 AIDQFSPTIYTTRSASRAIPIPNSAGSSPQHQMHHSQPRIAIGINQMEGGGPTRSTGAFSASPSI 1072
                                           |:|........||.....|...|:
Zfish   427 -------------------------------QLHTPAVNSLFGIALPIDGDEDRN---------- 450

  Fly  1073 YAYPHSPFYASSPETSFGSAAMPGHPAASSRISFSYDPAFQRLQVPNASGDRRPRSPLECASVFA 1137
               |.:.||.:.|
Zfish   451 ---PSTAFYQAFP---------------------------------------------------- 460

  Fly  1138 AVAAAATCGDAAGGAADTVISSASGTSAVAIDNKIEQAMDLVKSHLMIAVREEVEVLKERISELM 1202
                        .|.:..:...|||.|.|||||||||||||||||||.|||||||||||:|.||.
Zfish   461 ------------NGRSKAISDGASGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELY 513

  Fly  1203 DKINKLELENSILKSNIPQETLQQLQLQLQLAAPPATPAIQAAPAVQSVVAPAAAGQAVQQQAAG 1267
            ::.:.||.||::|||....|.|.||..|:.   .|::.:.|     |:.|      .|:.|:|:.
Zfish   514 ERNSVLERENAVLKSLANNEQLTQLTTQIH---NPSSTSPQ-----QTTV------NAILQEASK 564

  Fly  1268 AVAVTGVATSPASAVVPTSIPNGS 1291
            .||            :||. ||.|
Zfish   565 LVA------------LPTQ-PNVS 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bun	NP_001036357.2	TSC22	1176..1223	CDD:279505	30/46 (65%)
tsc22d2	XP_009294776.1	FAM196	<135..>392	CDD:291917	89/537 (17%)
tsc22d2	XP_009294776.1	TSC22	487..543	CDD:279505	35/55 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589770
Domainoid	1	1.000	89	1.000	Domainoid score	I7874
eggNOG	1	0.900	-	-		E1_KOG4797
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4363
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25341
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2903
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.780