Protein Alignment bun and Tsc22d1

DIOPT Version :10

• Sequence 1: NP_001036357.2
• Gene: bun / 34665
• FlyBaseID: FBgn0259176
• Length: 1331
• Species: Drosophila melanogaster
• Sequence 2: NP_997535.2
• Gene: Tsc22d1 / 21807
• MGIID: 109127
• Length: 1077
• Species: Mus musculus
• Alignment Length: 1382
• Identity: 339/1382 - (24%)
• Similarity: 489/1382 - (35%)
• Gaps: 449/1382 - (32%)

  Fly    12 PASSNAGPGNNPVRRNSMLTPSRGVTIGGTGGNIRKL----TKVS-SLTSNHHFAVCYPPSNIYQ 71
            |.|:.|......:....|..|:.....|..||:...|    |.|| :..|:..|.   |||.:..
Mouse     5 PESTAAAAAAADISARKMAHPAMFPRRGSGGGSASALNAAGTGVSGAAPSSEDFP---PPSLLQP 66

  Fly    72 NSNNAGSNSALQRTTSESLRLNMMSR-------VAAG--------------ATPTTVSRA-SSNS 114
            ....|.|....|....:|  ||::|:       :|.|              .||..:|.: |||:
Mouse    67 PPPAASSTQGPQPPPPQS--LNLLSQAQLQGQPLAPGGTQMKKKSGFQITSVTPAQISASISSNN 129

  Fly   115 SLATSTST------SLAPKSSSSS----GGSNSTPQQQQQQLVSSNNSSSSSNNSFTKASSPNNN 169
            |:|..|.:      |.....|||.    ..|.:|...:.::     :||..:.|:|.:|.:|
Mouse   130 SIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPER-----SSSEETLNNFQEAETP--- 186

  Fly   170 GARS--------------------VGGAATSAATGTTAAAGSHHHQPHHHHHHHHHHHQHHNHQQ 214
            ||.|                    :.|.|             |.|..|||||.||.||.||.|..
Mouse   187 GAVSPNQPHLPQPHLPHLPQQNVVINGNA-------------HPHHLHHHHHPHHGHHLHHGHHH 238

  Fly   215 QQQQQT---SLSQGHASLTVAGGSASAGGGGGG------GSGSSSGTAAG-GTN-RKPKTTSSFE 268
            ......   |:..|..|..|:...::.|...||      .:..|||..|. .|| |.|.||.|..
Mouse   239 SSHAAVAGPSIPGGPPSSPVSRKLSTTGSSDGGVPVAPPPAVPSSGLPASVMTNIRTPSTTGSLG 303

  Fly   269 ITSVTVGHPKLNAAGDTGDESADDLDESHTDDNSRITDLENETPSMSEDTFSKEEVYYAN--NAL 331
            |.|||                     .:...:|..|..:.:.:||::........:..:|  ||.
Mouse   304 INSVT---------------------GTSATNNVNIAAVGSFSPSVTNSVHGNANINTSNIPNAA 347

  Fly   332 STNAPVIPTSSQYGLVVVDPIAPSLGQ-TIQNVQVNVSDNIINVVSGAVTPGGTKKKDDIKETQH 395
            |.:.....||     ||...|...:|. |:.:..  |:::::|..:| :|.|....:...::.|.
Mouse   348 SISGGPGVTS-----VVNSSILSGMGNGTVSSSP--VANSVLNAAAG-ITVGVVSSQQQQQQQQQ 404

  Fly   396 ---RSERFKVVKIEST-EPFKRGRWMCMDYLDHSSVGNGGNNNEKTGSSTSEAHAATTDGGAAGV 456
               .:.||:|||::|| ||||:|||.|.::.:                  .|.....|:|.|
Mouse   405 PTVNTSRFRVVKLDSTSEPFKKGRWTCTEFYE------------------KENAVPATEGVA--- 448

  Fly   457 GAGSEAPAHKTTQSMILPPTQKLNENHLEANSTDANWNYAEQQQQQQQQQQQQQTIVGNALTKTL 521
                   .:|..:::...||        ||:|:                  ::::..|::::.
Mouse   449 -------VNKVVETVKQTPT--------EASSS------------------ERESTSGSSVSS-- 478

  Fly   522 PVALRNVSRSSSVTRSPNATVEFLSPNLLAQQQQQQQQLFDSVNANAASSPNPAGDPNNMDYART 586
                 :||..|..|.|..:.....:|.::|.||                .|.|...|.....|
Mouse   479 -----SVSTLSHYTESVGSGEMMGAPAVVAPQQ----------------PPLPPAPPGLQGVA-- 520

  Fly   587 AAMQLHQTLQQLKQREDAMDVPPGAGGYANYQNGGDSAVGAASNNNSAAAATGESQLSTSYVEQQ 651
                    ||||:                 :.:....::.|.|...|.:    :||:|...::.|
Mouse   521 --------LQQLE-----------------FSSPAPQSIAAVSMPQSIS----QSQMSQVQLQPQ 556

  Fly   652 Q---QQQQPLSPAPL--TPQAA----PTFAAV-----AAGQSPNF------QLEQQQQQQQATSQ 696
            :   ||:|.|.|.||  |..||    |:..:|     |.||.|:.      ||...|......:.
Mouse   557 ELSFQQKQTLQPVPLQATMSAATGIQPSPVSVVGITAAVGQQPSVSSLAQPQLPYSQTAPPVQTP 621

  Fly   697 IDGIVPQPFNPQQQQQQTPQQSTAQQAAAAANATSAVTAPPPQQTSNTSNAAVTTGQGQTMPLLS 761
            :.|..||.....|||...|.|                               :..|.||  |:..
Mouse   622 LPGAPPQQLQYGQQQPMVPAQ-------------------------------IAPGHGQ--PVTQ 653

  Fly   762 HMTS---YEQQQP------NLGAAAAAAAAGGTAATSVAAPQAI-------------------PT 798
            :.||   .:||||      :.|.:::.....|.:...||..|.|                   |.
Mouse   654 NPTSEYVQQQQQPIFQAALSSGQSSSTGTGAGISVIPVAQAQGIQLPGQPTAVQTQPAGAAGQPI 718

  Fly   799 LQLQSAPSTI-------ADPQQLMVPQQQQQQQHQEE----QQQQPQQQQQPLP-PANIASASAN 851
            .|.|:|.||:       :..||..:|...||...|..    ||..|...|..|| |..|......
Mouse   719 GQAQTAVSTVPTGGQIASIGQQANIPTAVQQPSTQVTPSVIQQGAPPSSQVVLPAPTGIIHQGVQ 783

  Fly   852 NSNLNLTNTNVVATGEATTNALTLTDEQATAALAAAFATGAAAAATGATSAAAATQQQIQQLQQQ 916
            ....:|....|:|             .|:|.........|....|.|..|      ||:......
Mouse   784 TRASSLPQQLVIA-------------PQSTLVTVPPQPQGVETVAQGVVS------QQLPTGSPL 829

  Fly   917 PNAESETESFITASNPGGNRKRAFSNPHIGGPNDPSFMHRLNPQLYYYNKSQSGRSSFCVDESLW 981
            |:|     |.|:.:|      :..|....|.|:.|:  :.:.||    |.:|
Mouse   830 PSA-----STISVTN------QVSSAAPSGMPSVPT--NLVPPQ----NIAQ------------- 864

  Fly   982 PTNNPNGAVSDTNLYMGSSTDEDYEEAIDQFSPTIYTTRSASRAIPIPNSAGSSPQHQMHHSQPR 1046
            |....||::               .:::.| ||.|.|..:...|..||.|:.......:..
Mouse   865 PPATQNGSL---------------VQSVSQ-SPLIATNINLPLAQQIPLSSTQFSTQSLAQ---- 909

  Fly  1047 IAIGINQMEGGGPTRSTGAFSASPSIYAYPHSPFYASSPETSFGSAAMPGHPAASSRISFSYDPA 1111
             ||| :|||..                ..|..|.....|:|      |.|.....|.:|   |.:
Mouse   910 -AIG-SQMEDA----------------RRPAEPSLGGLPQT------MSGDSGGMSAVS---DGS 947

  Fly  1112 FQRLQVPNASGDRRPRSPLECASVFAAVAAAATCGDAAGGAADTVISSASGTSAVAIDNKIEQAM 1176
            ...|..|              ||:|.......|.....|.      ..:||.|.|||||||||||
Mouse   948 SSSLAAP--------------ASLFPLKVLPLTTPLVDGE------DESSGASVVAIDNKIEQAM 992

  Fly  1177 DLVKSHLMIAVREEVEVLKERISELMDKINKLELENSILKSNIPQETLQQLQLQLQLAAPPATPA 1241
            ||||||||.|||||||||||:|.||::|.::||.||::||:....|.|.|.|.|||..:||||
Mouse   993 DLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPAT-- 1055

  Fly  1242 IQAAPAVQSVVAPAAAG 1258
            .|.....|....||:.|
Mouse  1056 TQPQGTTQPPAQPASQG 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bun	NP_001036357.2	ZIP_TSC22D	1175..1223	CDD:409276	31/47 (66%)
Tsc22d1	NP_997535.2	Required for interaction with TGFBR1 and promotion of TGF-beta signaling. /evidence=ECO:0000250|UniProtKB:Q15714	1..98		24/97 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..112		23/94 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	125..283		44/178 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	458..492		11/66 (17%)
		PHA03247	<568..878	CDD:223021	86/406 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	842..874		11/65 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	909..947		15/68 (22%)
		ZIP_TSC22D1	987..1065	CDD:409278	48/79 (61%)
		Leucine-zipper	1010..1031		11/20 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1042..1077		14/33 (42%)