DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bun and tsc22d2

DIOPT Version :9

Sequence 1:	NP_001036357.2	Gene:	bun / 34665	FlyBaseID:	FBgn0259176	Length:	1331	Species:	Drosophila melanogaster
Sequence 2:	XP_004914521.1	Gene:	tsc22d2 / 100145344	XenbaseID:	XB-GENE-978247	Length:	751	Species:	Xenopus tropicalis

Alignment Length:	1067	Identity:	233/1067 - (21%)
Similarity:	354/1067 - (33%)	Gaps:	382/1067 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 KTTSSFEITSVTVGHPKLNAAGDTGDESADDLDESHTDD-NSRITDLENETP---------SMSE 316
            |..|.|:||||.......:...:|  ||.||.|||.|:| :|.|.|:...|.         |.||
Frog     7 KKKSCFQITSVITAQSASSITEET--ESLDDPDESRTEDVSSEIFDVSRATDYGPEDVVERSSSE 69

  Fly   317 DTFSKEEVYYANNALSTNAPVIPTSSQYGLVVVDPIAPSLGQ-TIQNVQVNVSDNIINVVSGAVT 380
            :|.|.........|:|.|.|      |.|:.|:.....::.: :.|...:.:::.:.:..:..:|
Frog    70 ETLSNVGESETPGAVSPNVP------QDGIGVIGTNGGTMSRGSGQGATLGLTNQLSSGTATQIT 128

  Fly   381 PGGT---------------KKKDDIKETQHRSERFKVVKIE--STEPFKRGRWMCMDYLDHSSVG 428
            |..|               ........|...|.||:|:|::  |.||::||||.|.::.|..|
Frog   129 PAATATPTASSVPLVSSQSAATSSTTTTTTCSSRFRVIKLDHGSGEPYRRGRWTCTEFYDRDS-- 191

  Fly   429 NGGNNNEKTG-----SSTSEAHAATTDGGAAGVGAGSEAPAHKTTQSMILPPTQKLNENHLEANS 488
             ......:||     :||.: |:|..|.|....|....|.|              ::..|...::
Frog   192 -DATLITRTGDAIRHTSTFD-HSADRDSGLGATGGSVVASA--------------VHGGHGSESA 240

  Fly   489 TDANW---NYAEQQQQQQQQQQQQQTIVGNALTKTLPVALRNVSRSSSVTRSPNATVEFLSPNLL 550
            .|::.   :...|.::..|..||||.::|......:      ||:.::....|.|..   |..::
Frog   241 VDSSLCAVSQLLQNEKMNQPSQQQQFLIGQQAVGGM------VSQGTAQQMYPGAVT---SQQMI 296

  Fly   551 AQQQQQQQQLFDSVNANAASSPNPAGDPNNMDYARTAAMQLH--QTLQQLKQREDAMDV-PPGAG 612
            .||.|.......:.|....||.|                 :|  |:...|.|::.::.| .|.|.
Frog   297 VQQSQSHTAAQSATNGKGTSSRN-----------------VHTVQSTISLTQQQPSVSVSQPQAF 344

  Fly   613 GYANYQNGGDSAVGAASNNNSAAAATGESQLSTSYVEQQQQQQQPLSPAPLTPQAAPTFAAVAAG 677
            .|:..|:|                                   ..:||.|             ||
Frog   345 TYSQVQSG-----------------------------------HMMSPQP-------------AG 361

  Fly   678 QSPNFQ----LEQQQQQQQATSQID-GIVPQPFNPQQQQQQTPQQSTAQQAAAAANATSAV-TAP 736
            |:...|    ::.|...|:.|:.:: ..|.|...|.|..|              |..|..: ..|
Frog   362 QTEYVQHITVIQSQGTTQKPTTSLNASTVAQSSLPGQHLQ--------------AGGTQLIGLLP 412

  Fly   737 PPQQTSNTSNAAVTTGQG-QTMPLLSHMTSYEQQQPNLGAAAAAAAAGGTAATSVAAPQAIPTLQ 800
            ....:.:..:..:.:||. |:.|:  |:     |.|..||..:..:.|
Frog   413 KTSDSVSQGSGLIQSGQATQSQPV--HV-----QHPGSGAQPSVPSIG----------------- 453

  Fly   801 LQSAPSTIADPQQLMVPQQQQQQQHQEEQQQQPQQQQQPLPPANIASASANNSNL---NLTNT-- 860
                          :|.|:...||                     .|.|:|.|.:   :||..
Frog   454 --------------IVQQKSINQQ---------------------VSGSSNVSGIPGGHLTMAPG 483

  Fly   861 --NVVATGEATTNALTLTDEQATAALAAAFATGAAAAATGATSAAAATQQQIQQLQQQPNAESET 923
              ||.|||...|            .:.:...:.:|...|...:.||..|..:    ....:.|.:
Frog   484 IQNVPATGTGVT------------GVPSTVPSVSATPVTMPIAPAAFVQSPL----SSHTSVSRS 532

  Fly   924 ESFITASNPGGNRKRAFSNPHIGGPNDPSFMHRLNPQLYYYNKSQSGRSSFCVDESLWPTNNPNG 988
            .|.|               |.:|.|                              ::..|:|.:.
Frog   533 NSLI---------------PTVGLP------------------------------TMQGTSNVHT 552

  Fly   989 AVSDTNLYMGSSTDEDYEEAIDQFSPTIYTTRSASRAIPIPNSAGSSPQHQMHHSQPRIAIGINQ 1053
            ::..:|              |:||.     |:|.|....|.:...|.|..|
Frog   553 SLPQSN--------------INQFQ-----TQSQSLVGQIDDRRKSEPLPQ-------------- 584

  Fly  1054 MEGGGPTRSTGAFSASPSIYAYPHSPFYASSPETSFGSAAMP--GHPAASSRISFSYDPAFQRLQ 1116
                            |.:......||.......:..:..:|  |.|.
Frog   585 ----------------PPMSLISEKPFVKVPITDTLTNPLLPVFGLPV----------------- 616

  Fly  1117 VPNASGDRRPRSPLECASVFAAVAAAATCGDAAGGAADTVISSASGTSAVAIDNKIEQAMDLVKS 1181
              :...||.|.|....|.......:...|            .|:|..:.||||||||||||||||
Frog   617 --DGDEDRNPSSAFYEAFHLKFRGSKKLC------------DSSSSANVVAIDNKIEQAMDLVKS 667

  Fly  1182 HLMIAVREEVEVLKERISELMDKINKLELENSILKSNIPQETLQQLQLQLQLAA-----PPATPA 1241
            |||.|||||||||||:|.||::|.:.||.||::|||....:.|.||..|..|:.     ||.|.|
Frog   668 HLMYAVREEVEVLKEQIKELIEKNSTLERENALLKSLSNNDQLSQLTNQAGLSTCQQQQPPVTTA 732

  Fly  1242 IQAAPAVQSVVAPAAAGQAVQQQAAGA 1268
                    .:.||..|..|.|...:.|
Frog   733 --------PISAPPNAHPAQQPNVSSA 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bun	NP_001036357.2	TSC22	1176..1223	CDD:279505	31/46 (67%)
tsc22d2	XP_004914521.1	PRK14971	<424..567	CDD:237874	44/281 (16%)
tsc22d2	XP_004914521.1	TSC22	662..716	CDD:366499	34/53 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9356
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I3992
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49512
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2903
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.990