DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and Slco1a6

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_570092.1	Gene:	Slco1a6 / 84608	RGDID:	69304	Length:	670	Species:	Rattus norvegicus

Alignment Length:	688	Identity:	153/688 - (22%)
Similarity:	276/688 - (40%)	Gaps:	105/688 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GCQKYARLRTFILVLAISGTLQGACESYFRVSAKQASFQFGWNPLIVDWLLVASGLFQA---VFA 100
            |.:.:|:::.|:|.|..:...:....:|......|...:|..:..||.   :.:|.|:.   :..
  Rat    12 GIRCFAKIKVFLLALTWAYASKALSATYMNSMLTQIERRFNISTSIVG---LINGSFEVGNLLLI 73

  Fly   101 LAFAYWADVYH-PIKWLVGTLMLQAVTCVVAVIPSIMNFADGNQAKDALLD--ANMCATSLAQFQ 162
            :..:|:....| ||...:|..:: .:.|.:..:|   :|..|....:..:.  :|:.:.|....:
  Rat    74 IFVSYFGRKRHRPIMIGIGCAVM-GLGCFIISLP---HFLMGRYEYETTISPTSNLSSNSFLCME 134

  Fly   163 RLTLT--------EAQSSSLTLAMLFVL--QLALGMGGLAYYTLGVSYIDDNSLSQDSPAVIGAA 217
            ..|.|        |......:|..::||  .:..|:|......||:|||:|.:.|::||..||..
  Rat   135 NRTQTLKPTQDPAECVKEMKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPFYIGIL 199

  Fly   218 LAARVFGQQA----GSF---LVLGVGLTH-------------VG-WWLGWVILA--------PFI 253
            ...::.|..|    |||   :.:.:|..:             || ||:|:::.|        ||.
  Rat   200 EVGKITGPIAAIWLGSFCATIYVDMGSVNTDDLTITPTDTRCVGAWWIGFLVCAGLNILISIPFF 264

  Fly   254 FVGAVLLGLFPKRLPKTVIHQAAQRI-IEQSSMRRFGSQFSTYMDDSDFWPSLKRLFNNRLLMFN 317
            |        |||..||......|... .::....|..::........||:..:|.|..|.:.|
  Rat   265 F--------FPKTFPKEGPEDMANETKNDEGDKHREKAKEEKRGITKDFFLFMKSLSCNPIYM-- 319

  Fly   318 LLSIMCVQSAVVNYGLQEESYLQSRFFLP-YNEQDGLAAEWRSAFVSYFLKPPVMALGMLISGLV 381
                :||.::|    ||...::....|.| |.|.....:...:.|:......|.:.:|.||||.:
  Rat   320 ----LCVLTSV----LQVNGFVSIFTFKPKYLEHHYGKSSSEAIFLMGLYTLPSVCVGYLISGFI 376

  Fly   382 ISKAKLSARKITGINIALSIHLVAIFIGLIFVQCDVGAIAGV----EGGKLKQPY---------C 433
            :.|.|::.:|...|:..|.:....:.:....:.||...|||:    ||  ::|.:         |
  Rat   377 MKKFKITLKKAAFISYCLGMSECLLSLCNFMLTCDNVPIAGLTTSYEG--IQQSFDMENTVLADC 439

  Fly   434 SSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLFEGCSCSGDQSLNSTGQMRATAG 498
            :::|.|....:.|||.:| .:.|.:||.|||.|........:.:.|||     :.|:|...|..|
  Rat   440 NTRCSCLTKTWDPVCGDN-GLAYITPCLAGCEKSVGSGINMVLQDCSC-----IQSSGNSSAVLG 498

  Fly   499 ACS-SDNCQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVLPQDKSLALAFELMIVGLFAYVPV 562
            .|: ..:|.:.:..|.|:::..:|...:..|...:|.||.:..::|||.:..:...:.:...:..
  Rat   499 LCNKGPDCANKLQYFLIITVFCSFFYSLSLIPGYMIFLRCMKSEEKSLGIGLQAFCMRILGGILA 563

  Fly   563 HLSYDIVTRTTCVYWA------PNYERCLLRETPKHGNILDILTASLILASVLFDILVYIFAKGL 621
            .:.:.::...||::|.      |.  .|...|.....:|...|.|:|..:|.|....:....:..
  Rat   564 PIYFGVLIDRTCLHWGTQKCGEPG--ACRTYEINSFRSIYLGLPAALRGSSYLPAFFILRLMRKF 626

  Fly   622 NL---YNCKVTDNNYTPSLYAPIPHEDATTSPSAPRGG 656
            ..   .|..|||:...........|.|...||.....|
  Rat   627 QFPGDINSPVTDHVEMMLTEKESEHTDVHRSPQVENDG 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	144/646 (22%)
		MFS	50..>267	CDD:119392	57/261 (22%)
		KAZAL_SLC21	430..483	CDD:238650	18/61 (30%)
Slco1a6	NP_570092.1	oat	1..625	CDD:273279	144/647 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..295		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..670		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810