DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and Slco1c1

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_445893.1	Gene:	Slco1c1 / 84511	RGDID:	628660	Length:	716	Species:	Rattus norvegicus

Alignment Length:	668	Identity:	154/668 - (23%)
Similarity:	275/668 - (41%)	Gaps:	121/668 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PGCQKYARLRTFILVLAISGTLQGACESYFRVSAKQASFQFGWNPLIVDWLLVASGLFQ----AV 98
            |.|.|   |:.|:..|:.....:...|.|.:.:..|...:|.....:|.   :..|.|:    .|
  Rat    37 PCCGK---LKVFLGALSFVYFAKALTEGYLKSTITQIERRFDIPSSLVG---IIDGSFEIGNLLV 95

  Fly    99 FALAFAYWADVYHPIKWLVGTLMLQAVTCVVAVIPSIM------NFADGNQAKDALLDANMCATS 157
            ......:.|.::.|.....|.|::...|.::||....|      .:...:.:.:...:.:.|...
  Rat    96 ITFVSYFGAKLHRPKIIGAGCLVMGFGTMLIAVPQFFMEKYSYEKYERYSPSSNLTPNISPCYLE 160

  Fly   158 LAQFQRLTLT-----------EAQSSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDSP 211
            .:.....::.           |..:||.....:|:..|..|:|......||::|:||.:...::.
  Rat   161 SSSPSPRSIVGKSQNKINDECEVDTSSSMWVYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAA 225

  Fly   212 AVIG----AALAARVFGQQAGS-----FLVLG-VGLTHV-----------GWWLGWVILAPFIFV 255
            ..||    .|:...:||...||     ::.:| |.|.|:           .||||::|......:
  Rat   226 FYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGFLSLL 290

  Fly   256 GAVLLGLFPKRLPKTVIHQAAQRIIEQSSMRRFGSQFSTYMDD-------------------SDF 301
            .||.....||.||::       :..|.|......|:|.|  ||                   .||
  Rat   291 AAVPFWCLPKTLPRS-------QSREDSGSSSEKSKFIT--DDPVNYQMAPREESMKIMEMARDF 346

  Fly   302 WPSLKRLFNNRLLMFNLLSIMCVQSAVVN--YGL--QEESYLQSRFFLPYNEQDGLAAEWRSAFV 362
            .||||.||.|.:.:..|    |..:...|  :|:  .:..|::        :|.|.::. ::.||
  Rat   347 LPSLKSLFRNPVYILYL----CASTVQFNSLFGMVTYKPKYIE--------QQYGQSSS-KANFV 398

  Fly   363 SYFLKPPVMALGMLISGLVISKAKLSARKITGINIALSIHLVAIFIGLIFVQCDVGAIAGV---- 423
            ...:..|.:|||:...|:|:.|.:|...:.|.:.:..|:....:|:.|..:.|:..::||:
  Rat   399 IGLINIPAVALGIFSGGIVMKKFRLGICEATKLYLGSSVFGYLLFLSLFALGCENSSVAGLTVSY 463

  Fly   424 EGGKLKQPY-------CSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLFEGCSC 481
            :|.|....:       |:|:|.|:.:.:.|:|.:| .:||.|.|.|||...:......:|..|:|
  Rat   464 QGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGDN-GITYASACLAGCQSSSRSGKNIIFSNCTC 527

  Fly   482 SG---DQSLNSTGQMRATAGACSSDN-CQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVLPQD 542
            .|   .:|.|.:|.|    |.|..|| |....:.|.::|:..::.:.:|.|...::.||.:.||.
  Rat   528 VGFAAPKSGNWSGMM----GRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQL 588

  Fly   543 KSLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYWAPNYER------CLLRETPKHGNILDILTA 601
            ||.||....:.|.:.|.:|..:.:.::..|:|:.|  .:::      |.|.::....:|...||.
  Rat   589 KSFALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKW--GFKKCGSRGSCRLYDSHAFRHIYLGLTT 651

  Fly   602 SLILASVLFDILVYIFAK 619
            .|...||.....|.:..|
  Rat   652 LLGTVSVFLSTAVLLVLK 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	153/666 (23%)
		MFS	50..>267	CDD:119392	50/258 (19%)
		KAZAL_SLC21	430..483	CDD:238650	17/59 (29%)
Slco1c1	NP_445893.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		OATP	44..642	CDD:281175	142/629 (23%)
		MFS	46..>459	CDD:119392	91/437 (21%)
		KAZAL_SLC21	476..529	CDD:238650	17/53 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810