DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and SLCO5A1

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_112220.2	Gene:	SLCO5A1 / 81796	HGNCID:	19046	Length:	848	Species:	Homo sapiens

Alignment Length:	712	Identity:	162/712 - (22%)
Similarity:	272/712 - (38%)	Gaps:	145/712 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 TFILVLAISGTLQGACESYFRVSAKQAS--------FQFGWNPLIVDWLLVASG-----LFQAVF 99
            |||..|.:||.|.....:..|..:.::|        |..| |.::|.::....|     |:.||.
Human   138 TFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIG-NLVVVVFVSYFGGRGRRPLWLAVG 201

  Fly   100 ALAFAYWADVYHPIKWLVGTLMLQAVTCVVAVIPSIMNFADGNQAKDALLDANMCATSLAQFQRL 164
            .|..|:.|.::....::.....:|.:.   |..|:......||..  |.|:...|...
Human   202 GLLIAFGAALFALPHFISPPYQIQELN---ASAPNDGLCQGGNST--ATLEPPACPKD------- 254

  Fly   165 TLTEAQSSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDSPAVIGAALAARVFGQQAGS 229
              :...:..:.:|:....|:.:|||....||||.:|:|||...::|...:.........|...|
Human   255 --SGGNNHWVYVALFICAQILIGMGSTPIYTLGPTYLDDNVKKENSSLYLAIMYVMGALGPAVG- 316

  Fly   230 FLVLG--VGL-------THV---------GWWLGWVILAPFIFVGAVLLGLFPKRLP-------- 268
            :|:.|  :|.       .|:         .||.|:::.|..:|:....:..|||:||
Human   317 YLLGGLLIGFYVDPRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKK 381

  Fly   269 --------------KTVIHQAAQRIIEQSSMRRFGSQFSTYMDDSDFWPSLKRLFNNRLLMFNLL 319
                          |...:.:.|...:.||| .||.      |..|...:..|:.:|...:|..|
Human   382 KKFSVDAVSDDDVLKEKSNNSEQADKKVSSM-GFGK------DVRDLPRAAVRILSNMTFLFVSL 439

  Fly   320 SIMCVQSAVVNYGLQEESYLQSRFFLPYNEQDGLAAEWRSAFVSYFLKPPVMALGMLISGLVISK 384
            |.....:.|..:......:::|:|        |:.|...|.:....:.|.. .:|:::.|.:|.|
Human   440 SYTAESAIVTAFITFIPKFIESQF--------GIPASNASIYTGVIIVPSA-GVGIVLGGYIIKK 495

  Fly   385 AKLSARKITGINIALSIHLVAIFIGLIFVQCDVGAIAGVE-----GGKLKQPY------CSSQCL 438
            .||.||:...:.:..|...:..|..|..|.|:...:.|:.     |..|..|:      |:..|.
Human   496 LKLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCG 560

  Fly   439 CTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLFEG------CSC-----------SGDQS 486
            |....:.||| .:..:|||:||.|||     :||..|..|      |:|           .|.:|
Human   561 CKIHEYEPVC-GSDGITYFNPCLAGC-----VNSGNLSTGIRNYTECTCVQSRQVITPPTVGQRS 619

  Fly   487 ----------LNSTGQMRATAGACSSDNCQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVLPQ 541
                      ||..|.  |.:|.|.. .| :.:|.|.:....|.|:.........::|||:|..:
Human   620 QLRVVIVKTYLNENGY--AVSGKCKR-TC-NTLIPFLVFLFIVTFITACAQPSAIIVTLRSVEDE 680

  Fly   542 DKSLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYWAPNYERCLLRETPKHGNILDILTASLILA 606
            ::..||..:.:::...||:|..:.:..|..|||:.|   .:.|.::.:....|:.........||
Human   681 ERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLW---QQECGVQGSCWEYNVTSFRFVYFGLA 742

  Fly   607 SVL-FDILVYIFAKGLNLYNCKVTDNNYTPSLYAPIPHEDATTSPSAPRGGSPVTTTTTSSP 667
            :.| |...::||   |..|:.|..::..........|     .|..:.|.|.|....|.|.|
Human   743 AGLKFVGFIFIF---LAWYSIKYKEDGLQRRRQREFP-----LSTVSERVGHPDNARTRSCP 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	151/662 (23%)
		MFS	50..>267	CDD:119392	54/247 (22%)
		KAZAL_SLC21	430..483	CDD:238650	21/75 (28%)
SLCO5A1	NP_112220.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91
		OATP	129..734	CDD:281175	145/640 (23%)
		MFS	131..>531	CDD:119392	92/424 (22%)
		KAZAL_SLC21	551..605	CDD:238650	20/59 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810