DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Eb and slco4a1

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001297061.1	Gene:	slco4a1 / 567865	ZFINID:	ZDB-GENE-060606-4	Length:	742	Species:	Danio rerio

Alignment Length:	743	Identity:	185/743 - (24%)
Similarity:	301/743 - (40%)	Gaps:	149/743 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HNTRNSDLSQIAVNANN---IPDDSVD-CGIKGLGWCRGPGC-QKYARLRTFILVLAISGTLQGA 62
            |||....| ::....|.   :|.||.: ||...|    .|.| |.:...|..:..|.::..|||.
Zfish    54 HNTGKLGL-ELTDPPNGLKFVPTDSENLCGWGAL----TPRCIQTFNTPRWVLFFLCVASFLQGM 113

  Fly    63 CESYF----------RVSAKQASFQFGWNPLIVDWLLVASGLFQAVFALAF-AYWADVYHPIKWL 116
            ..:.|          |:..:  |:|.|        |:.:|....|...|.| :|:....|..:||
Zfish   114 IINGFINTVITSIERRLDLR--SYQAG--------LIASSYDIAACLCLTFVSYFGGTGHKPRWL 168

  Fly   117 VGTLMLQAVTCVVAVIPSIMNFADGNQAKDALLDANMCATSLAQFQRLTLTEAQSSSLTLAMLFV 181
            ...:::.|:..:|..:|.....|...:..:.:   .:|:.:..:    |....:........:|:
Zfish   169 GWGVLVMALGSLVFALPHFTTPAYQVRVPERM---GLCSENHTE----TCVGEEGGLSAYRYVFM 226

  Fly   182 LQLAL-GMGGLAYYTLGVSYIDDNSLSQDSPAVIGAALAARVFGQQAGSFLVLGVGL---THVG- 241
            |..:| |:|....|||||:|:|:|..|..:|..||....|.:.|..|| :|:.|..|   |.:|
Zfish   227 LGQSLHGVGATPLYTLGVTYLDENVKSNYAPVYIGIFYTAAIVGPAAG-YLLGGFFLNIYTEIGQ 290

  Fly   242 --------------WWLGWVI-LAPFIFVGAVLLGLFPKRLPKTVIHQAAQRIIEQSSMRRFGSQ 291
                          ||:|::. .|..:.:...:|| :|::||.:. ...|.|:.|...::. |||
Zfish   291 TTELTPENPLWVGAWWIGFLAGGAAALLIALPILG-YPRQLPGSQ-RYVAMRVSEAHQLKD-GSQ 352

  Fly   292 FSTYMDDSDFWPSLKRLFNNRLLM-----FNLLSIMCVQSAVVNYGLQE--ESYLQSRFFLPYNE 349
            .:.  .|..|..::|.:..:.||:     |..|.:.....|.:..|:..  ..:|:|:|.|..:|
Zfish   353 VTA--SDPQFGKTVKDMPRSMLLLLKNPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSASE 415

  Fly   350 QDGLAAEWRSAFVSYFLKPPVMALGMLISGLVISKAKLSARKITGI-NIALSIHLVAIFIGLIFV 413
                ||.|..     ::..|....|..:.|.:|.|..|..|.|... .:...:.|:||||.|  |
Zfish   416 ----AATWFG-----YMVVPAGGGGTFLGGFIIKKLNLRCRGIIRFCMLCALVSLMAIFIFL--V 469

  Fly   414 QCDVGAIAGV-------------------------EGGKLKQP--YCSSQCLCTPTAFMPVCPEN 451
            .|....:|||                         ....|..|  .|:..|.|...:|.|||..:
Zfish   470 HCPNVPMAGVTISYYSNVTHNHNSALYLQKDKHNSSFSDLSNPTVACNIGCHCLEESFNPVCGAD 534

  Fly   452 SSVTYFSPCYAGCTKKTTINSF-----QLFEGCSC-SGDQSLNSTGQMRATAGAC-SSDNCQSAI 509
             .|.|||||:|||:...  ::|     |:|.|||| :|:.|....|  .|..|.| ||.|...|.
Zfish   535 -GVMYFSPCHAGCSSLN--HTFGPRGRQVFSGCSCVAGNISWGEQG--FAEEGRCVSSCNHMPAF 594

  Fly   510 IIFQIMSISVAFLMGVGAIGKTLITLRAVLPQDKSLALAFELMIVGLFAYVPVHLSYDIVTRTTC 574
            :.|..:.|...||..:.|:   ..|||.|....:|..|..:.::|.....:|..:::..|...:|
Zfish   595 LTFLFILILFTFLCSIPAL---TATLRCVPDSQRSFGLGIQWIVVRTLGGIPGPIAFGSVIDISC 656

  Fly   575 VYW---APNYERCLLRETPKHGNILDILTASLILASVLFDIL-VYIFAKGLNLY---------NC 626
            :.|   ...|..|.|    .|.:.:...:   ::|.:::.:| .:.|.....||         :|
Zfish   657 LLWEEQCGEYGSCYL----YHNSAMSQYS---LVAGIIYKVLGTFFFLLATLLYKPPPESPQSSC 714

  Fly   627 KVTDNNYTPSLYAPIPHEDA--TTSPSA 652
            :.||...:..|  ||....|  .::|.|
Zfish   715 ESTDVGESKDL--PIKDHPAEIISNPHA 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	168/674 (25%)
		MFS	50..>267	CDD:119392	57/247 (23%)
		KAZAL_SLC21	430..483	CDD:238650	24/60 (40%)
slco4a1	NP_001297061.1	OATP	99..677	CDD:281175	156/623 (25%)
		MFS	101..>285	CDD:119392	48/201 (24%)
		KAZAL_SLC21	512..567	CDD:238650	23/57 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810