DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and LOC556735

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_684701.3	Gene:	LOC556735 / 556735	-ID:	-	Length:	859	Species:	Danio rerio

Alignment Length:	815	Identity:	186/815 - (22%)
Similarity:	305/815 - (37%)	Gaps:	191/815 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SQIAVNANNIPDDSVDCGIKGLGW-----CRGPGCQKYARL--------------RTFILVLAIS 56
            |.:...||.       .|.|.||:     .|.| .:||.|:              .|||..|.:|
Zfish   104 SSMRTEANR-------AGGKKLGFSLARLIRFP-VRKYLRVILSDSRCFLFCMCYLTFIQSLMVS 160

  Fly    57 GTLQGACESYFRVSAKQASFQFGWNPLIVDWLLVASGLFQAVFALAFAYWADVYHPIKWL-VGTL 120
            |.|    .|......|:.|.:...:.|:|....:.| |...||   .:|:.......:|| ||.:
Zfish   161 GYL----SSVITTIEKRYSLRSSESGLLVSCFDIGS-LLVVVF---ISYFGGRGQRPRWLAVGGV 217

  Fly   121 MLQAVTCVVAVIPSIMN-----------------FADGNQAKDALLDANMCATSLAQFQRLTLTE 168
            .: ||...:..:|..::                 ..:||:::|| ||.:.|...         .|
Zfish   218 FI-AVGAALFSLPHFISPPYQIKEVNSSMGNEGLCLNGNRSRDA-LDVSSCPRD---------QE 271

  Fly   169 AQSSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDSPAVIGAALAARVFGQQAGSFLVL 233
            ....|:.:|:....|:.:|||....||||.:|:|||...:::...:.........|..|| :|:.
Zfish   272 GNDHSIYVALFVCAQVLVGMGSTPIYTLGPTYLDDNVKKENASLYLAIMYVMGALGPAAG-YLLG 335

  Fly   234 GVGL-----------------THVG-WWLGWVILAPFIFVGAVLLGLFPKRLP-----KTVIHQA 275
            ||.:                 ..|| ||.|:::.|..:.:....:..|||:||     |...|.|
Zfish   336 GVLIGFYVDPKTIVNIEQSDPRFVGNWWSGFLLCAFAMLLVIFPMFTFPKKLPPRHKKKKKKHAA 400

  Fly   276 AQR------IIEQSSMRRFGSQFSTYM----DDSDFWPSLKRLFNNRLLMFNLLSIMCVQSAVVN 330
            ...      ::::.|..: |...::.|    |..|...:..|:.:|...:|..||.....:.|..
Zfish   401 DSASNDDDDVLKEKSNSK-GQTVASSMGFGRDIKDLPKAAIRILSNMTFLFVSLSYTAESAIVTA 464

  Fly   331 YGLQEESYLQSRFFLPYNEQDGLAAEWRSAFVSYFLKPPVMALGMLISGLVISKAKLSARKITGI 395
            :......:::|:|        |:.|...|.:....:.|.. .:|:::.|.:|.|.||.||:...:
Zfish   465 FITFIPKFIESQF--------GIPASNASIYTGVIIVPSA-GVGIVLGGYIIKKLKLGARESAKL 520

  Fly   396 NIALSIHLVAIFIGLIFVQCDVGAIAGVEGGKLKQPY----------------CSSQCLCTPTAF 444
            .:..|...:..|..|..|.|:     .:..|.:..||                |:..|.|....:
Zfish   521 AMICSGVSLLCFSTLFIVGCE-----SINLGGINIPYTTGPTLTLTHRNLTGGCNVNCGCRINEY 580

  Fly   445 MPVCPENSSVTYFSPCYAGC-TKKTTINSFQLFEGCSC-------------SGDQ--------SL 487
            .||| .:..:|||:||.||| |........:.:..|:|             .|:|        .|
Zfish   581 APVC-GSDGITYFNPCLAGCSTVGNDSTGIRNYTDCACVQSRQVITPPTSGQGNQLQLVIVKTYL 644

  Fly   488 NSTGQMRATAGACSSDNCQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVLPQDKSLALAFELM 552
            |..|  .|.:|.|  |...:.:|.|.|....|..:.........::|||:|..|::..||..:.:
Zfish   645 NENG--FALSGKC--DRTCNTLIPFLIFLFIVTLITACAQPSAIIVTLRSVDEQERPFALGMQFV 705

  Fly   553 IVGLFAYVPVHLSYDIVTRTTCVYWAPNYERCLLRETPKHGNILDILTASL------ILASVLFD 611
            ::...||:|..:.:..|..|||:.|   .:.|.:     ||:..:....|.      :.||:.|.
Zfish   706 LLRTLAYIPTPIYFGAVIDTTCMLW---QQDCGI-----HGSCWEYDVTSFRFVYFGLAASLKFV 762

  Fly   612 ILVYIFAKGLNLYNCKVTDN------NYTPSLYAPIPHEDATTSP-SAPRGGSPVTTTTTSSPIQ 669
            ..::||   |..|:.|..::      .:.|.|        .|.|. ....||......|.|.||
Zfish   763 GFIFIF---LTWYSIKYKEDRLKRWQQHLPPL--------GTVSELICHAGGHKSHARTRSCPI- 815

  Fly   670 RRDAAPEPRTETAVFRNPSSVTTSSGGAQSIVEPS 704
             ....|||..:..:.....| .:..|.|...:.||
Zfish   816 -FTPRPEPPEQPPMNHGHCS-QSCPGNALKAITPS 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	162/709 (23%)
		MFS	50..>267	CDD:119392	59/252 (23%)
		KAZAL_SLC21	430..483	CDD:238650	19/82 (23%)
LOC556735	XP_684701.3	OATP	143..748	CDD:281175	147/652 (23%)
		MFS	146..>545	CDD:119392	96/433 (22%)
		KAZAL_SLC21	565..619	CDD:238650	17/54 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810