Protein Alignment Oatp33Eb and SLCO1C1

DIOPT Version :10

• Sequence 1: NP_609570.1
• Gene: Oatp33Eb / 34662
• FlyBaseID: FBgn0032435
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_001139418.1
• Gene: SLCO1C1 / 53919
• HGNCID: 13819
• Length: 730
• Species: Homo sapiens
• Alignment Length: 670
• Identity: 154/670 - (22%)
• Similarity: 277/670 - (41%)
• Gaps: 114/670 - (17%)

  Fly    38 PGCQKYARLRTFILVLAISGTLQGACESYFRVSAKQASFQFGWNPLIVDWLLVASGLFQA--VFA 100
            |.|   ..|:.|:..|:.....:...|.|.:.:..|...:|.....:|.   |..|.|:.  :..
Human    37 PCC---GELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVG---VIDGSFEIGNLLV 95

  Fly   101 LAF-AYWADVYHPIKWLVGTLMLQAVTCVVAVIPSIM----NFADGNQAKDALLDANMC------ 154
            :.| :|:....|..|.:....::..|..::..:|...    .:...:.:.::.|..:.|
Human    96 ITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESSS 160

  Fly   155 --ATSLAQFQRLTLT---EAQSSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDSPAVI 214
              ..|:.:..:..::   |..:||.....:|:..|..|:|......||::|:||.:...::...|
Human   161 QLPVSVMEKSKSKISNECEVDTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYI 225

  Fly   215 G----AALAARVFGQQAGS-----FLVLG-VGLTHV-----------GWWLGWVILAPFIFVGAV 258
            |    .|:...:||...||     ::.:| |.|.|:           .||||::|......:.||
Human   226 GCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAV 290

  Fly   259 LLGLFPKRLPKTVIHQAAQRIIEQSSMRRFGSQFSTYMDD------------------SDFWPSL 305
            .....||.||::...:.:....|:|..         .:||                  .||.|||
Human   291 PFWYLPKSLPRSQSREDSNSSSEKSKF---------IIDDHTDYQTPQGENAKIMEMARDFLPSL 346

  Fly   306 KRLFNNRLLMFNLLSIMCVQSAVVN--YGL--QEESYLQSRFFLPYNEQDGLAAEWRSAFVSYFL 366
            |.||.|.:....|    |..:...|  :|:  .:..|::        :|.|.::. |:.||...:
Human   347 KNLFGNPVYFLYL----CTSTVQFNSLFGMVTYKPKYIE--------QQYGQSSS-RANFVIGLI 398

  Fly   367 KPPVMALGMLISGLVISKAKLSARKITGINIALSIHLVAIFIGLIFVQCDVGAIAGV----EGGK 427
            ..|.:|||:...|:|:.|.::|......:.:..|:....:|:.|..:.|:...:||:    :|.|
Human   399 NIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTK 463

  Fly   428 LKQPY-------CSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLFEGCSCSG-- 483
            ....:       |:|:|.|:.|.:.|:|.|| .:||.|.|.|||..........:|..|:|.|
Human   464 PVSYHERALFSDCNSRCKCSETKWEPMCGEN-GITYVSACLAGCQTSNRSGKNIIFYNCTCVGIA 527

  Fly   484 -DQSLNSTGQMRATAGACSSDN-CQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVLPQDKSLA 546
             .:|.||:|    ..|.|..|| |....:.|.::|:..::.:.:|.|...::.||.:.||.||.|
Human   528 ASKSGNSSG----IVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFA 588

  Fly   547 LAFELMIVGLFAYVPVHLSYDIVTRTTCVYWAPNYERCLLRETPK--HGNILDILTASLILASVL 609
            |....:.:.:.|.:|..:.:.::..|:|:.|  .::||..|.:.:  ..|:......| |.||..
Human   589 LGIYTLAIRVLAGIPAPVYFGVLIDTSCLKW--GFKRCGSRGSCRLYDSNVFRYQIKS-IPASHC 650

  Fly   610 FDILVYIFAKGLNLYNCKVT 629
            :.|.....|...|.::|..|
Human   651 YSIPDLHNATDTNKFSCHFT 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	MFS_SLCO_OATP	46..536	CDD:340894	126/565 (22%)
		PHA03247	<635..813	CDD:223021
SLCO1C1	NP_001139418.1	MFS_SLCO1C_OATP1C	42..579	CDD:341017	127/566 (22%)