DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and Gm5724

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001365611.1	Gene:	Gm5724 / 435927	MGIID:	3643685	Length:	670	Species:	Mus musculus

Alignment Length:	741	Identity:	174/741 - (23%)
Similarity:	296/741 - (39%)	Gaps:	182/741 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RGPGCQKYARLRTFILVL---AISGTLQGACESYFRVSAKQASFQFGWNPLIVDWLLVAS-GLFQ 96
            ||..|  :::::.|:|.|   .:|.:|.|   |:.:....|...|||        ||.:: ||..
Mouse    11 RGVRC--FSKVKVFLLALTGACVSKSLTG---SHMKSMLLQIERQFG--------LLTSTVGLIT 62

  Fly    97 AVFALAF-------AYWADVYH-PIKWLVGTLMLQAVTCVVAVIPSIMNFADGNQAKDALLD--A 151
            ..|::..       :|:....| ||...|| .|...:.|.:..:|   :|..|....:..:.  :
Mouse    63 GSFSMGMLLVIIPVSYFGTKLHRPIMIGVG-CMFMGLGCFIISLP---HFLMGRYEYETTISPTS 123

  Fly   152 NMCATSLAQFQRLTLTEAQSSSLT--------LAMLFVL--QLALGMGGLAYYTLGVSYIDDNSL 206
            |:.:.|....:..:||...:...|        |..::||  .:..|||..|...||:|||:|.:.
Mouse   124 NLSSNSFLCMENRSLTLKPTQDTTECGREIKSLMWIYVLVGNIIRGMGETAIMPLGISYIEDFAK 188

  Fly   207 SQDSPAVIG----AALAARVFGQQAGSF----------------LVLGVGLTHVG-WWLGWVILA 250
            |::||..||    ....:...|...|||                .:.......|| ||:|:::.|
Mouse   189 SENSPLYIGILEIGITISYWIGYSLGSFCANIYVDTDSGNTDDLTITPTDTRWVGAWWIGFLVCA 253

  Fly   251 PFIFVGAVLLGLFPKRLPKTVIH-------------------QAAQRIIEQSSMRRFGSQFSTYM 296
            ...|:.::....|||.|||..:.                   :..||||:
Mouse   254 GVNFLTSIPFFFFPKTLPKEGLQDNGDGTENAKEEKHREKAKKENQRIIK--------------- 303

  Fly   297 DDSDFWPSLKRLFNNRLLMFNLLSIMCVQSAVVNYGLQEESYLQSRFFLP-YNEQD-GLAAEWRS 359
               ||:|.:|.|..|.:.|..||..:          ||..:::....::| |.||. |.::....
Mouse   304 ---DFFPLMKNLSCNPIYMLYLLISV----------LQFNTFVSMVSYVPKYLEQQYGKSSADVL 355

  Fly   360 AFVSYFLKPPVMALGMLISGLVISKAKLSARKITGINIALSIHLVAIFIGLIFVQCDVGAIAGV- 423
            ..:..::.||: .||.|:.||::.|.|::|:|...|...||:....:.:......||...:||:
Mouse   356 FIMGIYMLPPI-CLGYLLGGLIMKKFKITAKKAAYIAFCLSLTDYLLSLSNYMTNCDSFQVAGLT 419

  Fly   424 ---EGGKLKQPY---------CSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLF 476
               ||  ::.|.         |:::|.|....:.||| .|:.:.|.|.|.|||.|........:|
Mouse   420 ASYEG--VQHPLHVDHEVLADCNTRCSCLTNTWDPVC-GNNGLAYMSACLAGCEKSVGNGINMVF 481

  Fly   477 EGCSCSGDQSLNSTGQMRATAGACS-SDNCQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVLP 540
            :.|||     :.|:|...|..|.|: ..:|.:.:..|.|:.....|:..:.:|...::.||.:.|
Mouse   482 QNCSC-----IRSSGNSSAVLGLCNKGPDCDNMLKYFIIIFSVKMFIFSLSSIPGYMVLLRCMKP 541

  Fly   541 QDKSLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYWAPNYERCLLRETPKHGNILDILTASLIL 605
            ::|||.:........:||.:|..:.:..:....|::|.          |.|.|.         ..
Mouse   542 EEKSLGVGLHTFCTKIFAGIPAPIYFGALIDRACLHWG----------TLKCGE---------KA 587

  Fly   606 ASVLFDI--LVYIFAKGLNLYNCKVTDNNYTPSLYA-------PIPHEDATTSPSAPRGGSPVTT 661
            |..::||  ..|:|. ||   ...:|.::|.|:::.       .:| ||.         .||.|.
Mouse   588 ACRIYDINSFRYLFF-GL---PAALTGSSYLPAVFLLRLMRTFQLP-EDT---------DSPDTE 638

  Fly   662 TTTSSPIQRRDAAPEPRTETAVFRNP 687
            ...:..|::.:..      |.|.|:|
Mouse   639 LAETKLIEKENDC------TDVHRSP 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	158/664 (24%)
		MFS	50..>267	CDD:119392	63/261 (24%)
		KAZAL_SLC21	430..483	CDD:238650	19/61 (31%)
Gm5724	NP_001365611.1	oat	1..624	CDD:273279	163/689 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810