DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and Slco6d1

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_017452073.1	Gene:	Slco6d1 / 367321	RGDID:	1359388	Length:	723	Species:	Rattus norvegicus

Alignment Length:	609	Identity:	135/609 - (22%)
Similarity:	234/609 - (38%)	Gaps:	91/609 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DSVDCGIKGLGWCRGPGCQKYARLRTFILVLAIS----GTLQGACESYFRVSAKQASFQFGWNPL 83
            ||::.|..|||....|..|::..:..|:....:.    |.:.|..:...:|...:.|      |.
  Rat    61 DSLEEGSFGLGPLVFPCLQRFNNINCFLTAYFLGTMAHGMIFGLVDQSLKVYVSELS------PS 119

  Fly    84 IVDWLLVASGLFQAVF--ALAFAYWADVYHPIKWLVGTLMLQAVTCVVAVIPSIMNFADGNQAKD 146
            .::.|.:.||...|.|  :|..|::....:.::|:|....:..:..:|..||    |.:....|.
  Rat   120 KLETLTMGSGDDLAAFLVSLVGAHFGGRGNRVRWMVAACFVTGLASMVFAIP----FFNYEIIKL 180

  Fly   147 ALLDANMCATSLAQFQRLTLTEAQSSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDSP 211
            ..:...:|.......:....|.....|..:|.....|...|:.|:.:|.|..|:|.|:..:..|.
  Rat   181 GTVTDELCIEGKKTTKVCERTVIPHKSTCIAFFNFGQFLHGIAGMPFYLLAFSFIFDHVPTCSSG 245

  Fly   212 AVIGAALAARVFGQQAGSFLVLGV------------GLTHV--------GWWLGWVILAPFIFVG 256
            ..:..|..|...|...| :|| |:            .:.||        .||..:..:|.|.|..
  Rat   246 LYLAIADTALSVGYVLG-YLV-GIRNRMFPVKEDMKAVGHVQQFRILQRNWWRSYFAVAVFAFCT 308

  Fly   257 AVLLGLFPKRLPKTVIHQAAQRI-IEQSSM-----RRFGSQFSTYMDDSDFWPSLKR-------L 308
            .:.|..||.||      :.||:| :|:|..     ||        :.|.:..|.||.       |
  Rat   309 TLPLSCFPSRL------RGAQQIRLEKSKEPPTIDRR--------LKDKEIQPGLKGVLHAIWCL 359

  Fly   309 FNNRLLMFNLLSIMCVQSAVVNYGLQEESYLQSRFFL-PYNEQDGLAAEWRSAFVSYFLKPPVMA 372
            ..|.|::......:.....:.:.|.....:|||.|.: |.|         .|.....|:.|..:
  Rat   360 LRNPLVLTQTFCQVTKSLTLKSSGYFLPKFLQSHFLIVPTN---------ASILTGMFVLPGAL- 414

  Fly   373 LGMLISGLVISKAKLSARKITGINIALSIHLVAIFIGLIFVQCDVGAIAGVEG--------GKLK 429
            :|..:.|.::.:.::|.:.:....:..|...|.:|:...|..|:....||:..        |...
  Rat   415 IGRFLGGYIVDRLQMSTKVVLKFMMVSSFISVVLFLLTFFWSCETAGFAGINDDYDGLGKLGNFT 479

  Fly   430 QPYCSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLFEGCSC--SGDQSLNSTGQ 492
            .| |:..|.||.|.:..:|..:.. .|||.|:|||.....:...:.:..|||  .|..:.:..||
  Rat   480 AP-CNEYCGCTMTDYSTICGRDEK-QYFSACFAGCRASKPLRKEKAYYNCSCIKEGLTAPDDDGQ 542

  Fly   493 -MRATAGACSSDNCQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVLPQDKSLALAFELMIVGL 556
             ..|.:|.|:: .|.:..::|.....:..| ....::...:|.|::|.....|::|.....|...
  Rat   543 FFDAVSGTCNT-KCLTLPLLFAFYFAATVF-SNFCSVPSFMIVLKSVPASWNSMSLGVTYTIWRF 605

  Fly   557 FAYVPVHLSYDIVTRTTCVYWAPN 580
            ...||.||.::..:..||.:|..|
  Rat   606 LGSVPDHLLFESTSDYTCNFWDIN 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	135/609 (22%)
		MFS	50..>267	CDD:119392	49/242 (20%)
		KAZAL_SLC21	430..483	CDD:238650	17/54 (31%)
Slco6d1	XP_017452073.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810