DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Eb and slco1d1

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001335015.1	Gene:	slco1d1 / 326845	ZFINID:	ZDB-GENE-030131-5044	Length:	689	Species:	Danio rerio

Alignment Length:	734	Identity:	184/734 - (25%)
Similarity:	296/734 - (40%)	Gaps:	141/734 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PGCQKYARLRTFILVLA---ISGTLQGACESYFRVSAKQASFQFGWNPLIVDWLLVASGLFQA-- 97
            |.|.|   |:.|:..:.   .:...||   ||.:.|..|...:|.....::.::   .|.|:.
Zfish     9 PCCSK---LKMFLAAMCFVFFAKAFQG---SYMKSSVTQIERRFDVPSSLIGFI---DGSFEIGN 64

  Fly    98 VFALAFA--YWADVYHPIKWLVGTLMLQAVTCVVAVIP-----------SIMNFADGNQAKDALL 149
            :|.:||.  :.|.::.|.....|.|::.|.:.:.| :|           :|.:|:......:.:|
Zfish    65 LFVIAFVSYFGAKLHRPRLIAAGCLVMSAGSFITA-MPHFFQGQYKYESTISHFSASVNGTENVL 128

  Fly   150 DANMCAT--SLAQFQRLTLTEAQ-------SSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNS 205
            .   |.|  ||||...:...|:|       ||||.| .:|:..:..|:|......||:||:||.|
Zfish   129 P---CLTNASLAQDSEIPTVESQAECEKASSSSLWL-FVFLGNMLRGIGETPVMPLGLSYLDDFS 189

  Fly   206 LSQDSPAVIG----AALAARVFGQQAGSF---LVLGVGLTHV--------------GWWLGWVIL 249
            ..:::...:.    ..:...:||...|||   |.:.:|...:              .||||
Zfish   190 REENTAFYLALIQTVGIMGPMFGFMLGSFCAKLYVDIGTVDLDSITINYKDSRWVGAWWLG---- 250

  Fly   250 APFIFVGAVLL--GLFPKRLPKTVIHQAAQRIIEQSSMRRFGSQFSTYMDDS------------- 299
              |:..|.|:|  |:....|||::..|......::......|.|.....|::
Zfish   251 --FLVTGGVMLLAGIPFWFLPKSLTRQGEPESEKKPGAPEGGEQERFIPDNNKHNPPASKPAPVT 313

  Fly   300 ------DFWPSLKRLFNNRLLMFNLLSIMCVQSAVVNYGL-QEESYLQSRFFLP-YNEQDGLAAE 356
                  ||.||||:||:|.:.:.    ::|.       || |...::....|.| :.||....:.
Zfish   314 MSALAKDFLPSLKKLFSNTIYVL----LVCT-------GLIQVSGFIGMITFKPKFMEQVYGQSA 367

  Fly   357 WRSAFVSYFLKPPVMALGMLISGLVISKAKLSARKITGINIALSIHLVAIFIGLIFVQCDVGAIA 421
            .|:.|:...:..|.:|||::..|.::.:.|::......|.|..|:......:...|:|||...:|
Zfish   368 SRAIFLIGIMNLPAVALGIVTGGFIMKRFKVNVLGAAKICIVASVLAFCSMLIQYFLQCDNSQVA 432

  Fly   422 GVE---GGKLKQPY--------CSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQL 475
            |:.   .|..:..|        |:..|.|:...:.|:|..| .|||.|||.|||...|.|....:
Zfish   433 GLTVTYQGAPEVSYQTETLISQCNIGCSCSLKHWDPICASN-GVTYTSPCLAGCQTSTGIGKEMV 496

  Fly   476 FEGCSCSGDQSLNSTGQMRATAGAC-SSDNCQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVL 539
            |..|||.|:..|..| .|.|..|.| ...:|.....|:..:::..||...|||....:|.||::.
Zfish   497 FHNCSCIGEALLPYT-NMSAVLGQCPRKSDCDFMFKIYMAVTVIGAFFSAVGATPGYIILLRSIT 560

  Fly   540 PQDKSLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYWAPNYERCLLRETPKHG--NILD---IL 599
            |:.|||||....:||.....:|..:.:..:...||:.|.       |::....|  .|.|   ..
Zfish   561 PELKSLALGMHTLIVRTLGGIPPPIYFGALIDKTCLKWG-------LKQCGGRGACRIYDSGAFR 618

  Fly   600 TASLILASVLFDILVYIFAKGLNLYNCKVTDNNYTPSLYAPIPHEDATTSPSAPRGGSPVTTTTT 664
            .|.|.|...|:.....:|  || ||| :::......:|      :|...:|.....|...|....
Zfish   619 NAFLGLIYALYSSSYLLF--GL-LYN-RLSHREKKQAL------KDQLKAPEQDSCGVSTTNGNA 673

  Fly   665 SSPIQRRDAAPEPRTETAV 683
            ||.|.:   ...|..||.:
Zfish   674 SSAIVK---CENPDQETTI 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	168/668 (25%)
		MFS	50..>267	CDD:119392	61/266 (23%)
		KAZAL_SLC21	430..483	CDD:238650	22/60 (37%)
slco1d1	NP_001335015.1	OATP	16..617	CDD:308646	159/637 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910