DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and Slco1b2

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_065241.1	Gene:	Slco1b2 / 28253	MGIID:	1351899	Length:	689	Species:	Mus musculus

Alignment Length:	669	Identity:	158/669 - (23%)
Similarity:	263/669 - (39%)	Gaps:	150/669 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RTFILVLAISGTLQGACESYFRVSAKQASFQFGWNPLIVDWLLVASGLFQAVFALAFAYWADVYH 111
            |.|.:..:|||.:.|             .|:.| |.|::            ||.   :|:....|
Mouse    55 RRFDIPSSISGLIDG-------------GFEIG-NLLVI------------VFV---SYFGSKLH 90

  Fly   112 PIKWLVGT-LMLQAVTCVVAVIPSIM----NFADGNQAKDALLDANMCATSLAQFQRLTLT---- 167
            ..| |:|| ..:..:..::..:|...    .:|..|.....   .|...|.|.. |..:||
Mouse    91 RPK-LIGTGCFIMGIGSILTALPHFFMGYYRYATENDISSL---HNSTLTCLVN-QTTSLTGTSP 150

  Fly   168 -------EAQSSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDSPAVIGAALAARVFGQ 225
                   |..|:|.|...:.:..:..|:|......||||||||.:...:|...:|......:.|.
Mouse   151 EIMEKGCEKGSNSYTWIYVLMGNMLRGIGETPIVPLGVSYIDDFAKEGNSSMYLGTLHTIAMIGP 215

  Fly   226 QAG-------SFLVLGVGLTHV--------------GWWLGWVI--------LAPFIFVGAVLLG 261
            ..|       :.|.:.||...:              .||||:::        ..||.|:..:
Mouse   216 ILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCIICSIPFFFLPKI--- 277

  Fly   262 LFPKRLPKTVIHQAAQRIIEQSSMRRFGSQFSTYMDDSD------FWPSLKRLFNNRLLMFNLLS 320
              |||..|...:.|:..:::....:...:..:|....:.      .|.....|.|.:.::|.:|:
Mouse   278 --PKRSQKERKNSASLHVLKTDEDKNPVTNPTTQEKQAPANLTGFLWSLRSILTNEQYVIFLILT 340

  Fly   321 IMCVQSAVVNYGLQEESYLQSRFFLPYNEQDGLAAEWRSAFVSYFLKPPVMALGMLISGLVISKA 385
            ::.:.|.:.::     :||    |....:|.|..|. ::.|:...:..|.||.||.:.|.:|.:.
Mouse   341 LLQISSFIGSF-----TYL----FKFIEQQFGQTAS-QANFLLGVITIPTMASGMFLGGYLIKRL 395

  Fly   386 KLSARKITGINIALSIHLVAIFIGLIFVQCDVGAIAGV----EG-----GKLKQP--YCSSQCLC 439
            ||:...||......:......::....:.|:..|.||:    :|     ..:..|  ||:|.|:|
Mouse   396 KLTLLGITKFVFFTTTMAYVFYLSYFLLICENKAFAGLTLTYDGMNPVDSHIDVPLSYCNSDCIC 460

  Fly   440 TPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQ--------LFEGCSC---SGDQSLNSTGQM 493
            ....:.|||.|| .|||.|||.|||      .||:        .|..|||   ||.|.    |..
Mouse   461 DKNQWEPVCGEN-GVTYISPCLAGC------KSFRGDKKLMNIEFYDCSCVSGSGFQK----GNH 514

  Fly   494 RATAGACSSDNCQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVLPQDKSLALAFELMIV---- 554
            .|..|.|..|.|::....:....:.::|...:|:....||.:|:|.|:.|||.:.|..::|
Mouse   515 SARLGECPRDKCKTKYYFYITFQVIISFFTALGSTSLMLILIRSVQPELKSLGMGFHSLVVRTLG 579

  Fly   555 GLFAYVPVHLSYDIVTRTTCVYWAPN----YERCLLRETPKHGNI---LDILTASLILASVLFDI 612
            |:.|  ||:  |..:...||:.|:..    ...|.|..:...|.|   |.|...:.||  :|:..
Mouse   580 GILA--PVY--YGALIDRTCMKWSVTSCGARGACRLYNSRLFGMIYVGLSIALKTPIL--LLYVA 638

  Fly   613 LVYIFAKGLNLYNCKVTDN 631
            |:|:..:.:...:.|:.:|
Mouse   639 LIYVMKRKMKRNDNKILEN 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	156/655 (24%)
		MFS	50..>267	CDD:119392	55/261 (21%)
		KAZAL_SLC21	430..483	CDD:238650	26/65 (40%)
Slco1b2	NP_065241.1	MFS	26..557	CDD:421695	129/561 (23%)
Slco1b2	NP_065241.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..689		158/669 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810