DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and SLCO3A1

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_037404.2	Gene:	SLCO3A1 / 28232	HGNCID:	10952	Length:	710	Species:	Homo sapiens

Alignment Length:	712	Identity:	172/712 - (24%)
Similarity:	276/712 - (38%)	Gaps:	186/712 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RNSDLSQIAVNANNIPDDSVDCGIKGLGWCRGPGCQKYARLRTFI-----LVLAISGTLQGACES 65
            |:.:|.......|......|.|               ::.::.|:     |:||     ||...:
Human    14 RSGELQGDEAQRNKKKKKKVSC---------------FSNIKIFLVSECALMLA-----QGTVGA 58

  Fly    66 YF---------RVSAKQA-------SFQFGWNPLIV-----------DWLLVASGLFQAVFALAF 103
            |.         |.:.:.|       ||:.|...||:           ..|:...|:..|:.||..
Human    59 YLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLS 123

  Fly   104 AYWADVYHPIKWLVGTLMLQAV---TCVVAVIPSIMNFADGNQAKDA-LLDANMCATSLAQFQRL 164
            |....:.|..|:..|.:...|.   .|..       |.:.|::..|. |:..|..||::...
Human   124 ALPEFLTHQYKYEAGEIRWGAEGRDVCAA-------NGSGGDEGPDPDLICRNRTATNMMYL--- 178

  Fly   165 TLTEAQSSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDSPAVIGAALAARVFGQQAGS 229
                         :|...|:.||:|......||||||||:...:||...||......|||...|
Human   179 -------------LLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACG- 229

  Fly   230 FLVLGVGLTHV-----------------------GWWLGWVILAPFIFVGAVLLGLFPKRLPKTV 271
             .:||...|.:                       .||.|:::....:|..::|:..||:.||.
Human   230 -FILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPP-- 291

  Fly   272 IHQAAQRIIEQS--SMRRF----------------GSQFSTYMDDSDFWPSLKRLFNNRLLMFNL 318
             |.......||:  |.|.:                .|..|.:..........|.|.:|.:....:
Human   292 -HSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCII 355

  Fly   319 LSIMCVQSAVV-NYGLQEESYLQSRFFL---PYNEQDGLAAEWRSAFVSYFLKPPVMALGMLISG 379
            |: .|::.||| .:......||:.:|.|   ..|:..|:.|            .|...||:.:.|
Human   356 LA-ACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTA------------IPCACLGIFLGG 407

  Fly   380 LVISKAKLSARKITGINIALSIHLV--AIFIGLIFVQCDVGAIAGV--------EGGKLKQPY-- 432
            |::.|..|||  :..|.:|:.::||  |.::..:|:.||.|.:|||        ..|....||
Human   408 LLVKKLSLSA--LGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSP 470

  Fly   433 CSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLFEGCSCSGDQSLNSTGQMRATA 497
            |::.|.|...:|.|||..: .:||.|.|:|||      ||..| .||:|     |.:.....||.
Human   471 CNNNCECQTDSFTPVCGAD-GITYLSACFAGC------NSTNL-TGCAC-----LTTVPAENATV 522

  Fly   498 --GACSSDNCQSAIIIFQIMSISVAFLMGVGAIGKT---LITLRAVLPQDKSLALAFELMIVGLF 557
              |.|.|..||.|.:.| :..:.:..|  :||:.:|   :|.:|.|.|:.||.||....:::.|.
Human   523 VPGKCPSPGCQEAFLTF-LCVMCICSL--IGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLL 584

  Fly   558 AYVPVHLSYDIVTRTTCVYWAP---NYERCLLRETPKHGNIL-DILTASLILASVLFDILVY 615
            .::|..|.:.....:||::|:.   ....|:|     :.|:: ..|..|:.:|...|..::|
Human   585 GFIPPPLIFGAGIDSTCLFWSTFCGEQGACVL-----YDNVVYRYLYVSIAIALKSFAFILY 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	169/695 (24%)
		MFS	50..>267	CDD:119392	62/275 (23%)
		KAZAL_SLC21	430..483	CDD:238650	22/54 (41%)
SLCO3A1	NP_037404.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		2/10 (20%)
		OATP	41..619	CDD:281175	161/646 (25%)
		MFS	47..>286	CDD:119392	60/268 (22%)
		KAZAL_SLC21	467..511	CDD:238650	21/51 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145477
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740