DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and Slco4c1

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_766246.1	Gene:	Slco4c1 / 227394	MGIID:	2442784	Length:	722	Species:	Mus musculus

Alignment Length:	652	Identity:	159/652 - (24%)
Similarity:	268/652 - (41%)	Gaps:	112/652 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GWCRG--PGC-QKYARLRTFILVLAISGTLQG-ACESYFRVSAKQASFQFGWNPLIVDWLLVASG 93
            || ||  |.| |:....:.|:|...:....|| .......:|......::.....:...:..:..
Mouse    85 GW-RGFHPQCLQRCNTPQGFLLHYCLLALTQGIVVNGLVNISISTIEKRYEMKSSLTGLISSSYD 148

  Fly    94 LFQAVFALAFAYWADVYHPIKWLVGTLMLQAVTCVVAVIPSIMNFADGNQAKDALLDANMCATSL 158
            :...|.:|..:::.:..|..:||.....:..:..:|..:|   :|..|.....::.: :.|.|.
Mouse   149 ISFCVLSLFVSFFGERGHKPRWLAFASFMIGLGALVFSLP---HFFSGRYELGSIFE-DTCLTR- 208

  Fly   159 AQFQRLTLTEAQSSSLTLA---MLFVL-QLALGMGGLAYYTLGVSYIDDNSLSQDSPAVIGAALA 219
                  ..|...||:..|:   .:||| ||.||.||...||||.::|||:..:..|...||...:
Mouse   209 ------NSTRCSSSTSLLSNYFYVFVLGQLLLGTGGTPLYTLGTAFIDDSVPTHKSSLYIGIGYS 267

  Fly   220 ARVFGQQAGSFLVLGVGLTHV---------------------GWWLG--------WVILAPFIFV 255
            ..:.|...|  .|||..|..:                     .||:|        |.::.||
Mouse   268 MSILGPAIG--YVLGGQLLTMYIDIAMGQSSDLTEDDPRWLGAWWIGFLLAWLFAWSLIMPF--- 327

  Fly   256 GAVLLGLFPKRLPKTVIHQAAQRIIEQSSMRRFGSQFSTYMDDS------DFWPSLKRLFNNRLL 314
                 ..|||.||.|...||.    :.|...:..|....:.|::      ||..::|.|..|  .
Mouse   328 -----SCFPKHLPGTAKIQAG----KTSQTHQNNSTSFQHTDENFGKSIKDFPTAVKNLMRN--T 381

  Fly   315 MFNLLSIMCVQSAVVNYGLQEESYLQSRFFLP--YNEQDGLAAEWRSAFVSYFLKPPVMALGMLI 377
            :|..|.:.....|::..|...        |||  ...|.||.:.:.:......|.|.. |||.::
Mouse   382 VFICLVLSTTSEALITTGFAT--------FLPKFIENQFGLTSSFAATLGGAVLIPGA-ALGQIL 437

  Fly   378 SGLVISKAKLSARKITGINIALSIHLVAIFIGLIFV--QCDVGAIAGV--------EGGKLKQPY 432
            .|:::||.|:..:..  :..||....||:.:..:|:  :|:....|||        |.|.|..|
Mouse   438 GGVLVSKFKMKCKNT--MKFALCTSGVALVLSFVFIYAKCENEPFAGVSESYNGTGEMGNLTAP- 499

  Fly   433 CSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLFEGCSCSGDQSLNSTGQ---MR 494
            |::.|.|..:.:.|:| .:..:.|||||:|||....:....:::..|||. ::.:.||.:   ..
Mouse   500 CNANCNCLRSYYYPLC-GSDGIQYFSPCFAGCLNSVSNRKPKVYYNCSCI-ERKITSTAESTDFE 562

  Fly   495 ATAGACSSDNCQSAIIIFQIMSISVAFLMGVGAIGKTLIT---LRAVLPQDKSLALAFELMIVGL 556
            |.||.|.: .|.:..|...|..|:|.|....|    |.||   ||.|..:.:||||..:.|::.|
Mouse   563 AKAGKCRT-RCSNLPIFLGIFFITVIFTFMAG----TPITVSILRCVNHRHRSLALGVQFMLLRL 622

  Fly   557 FAYVPVHLSYDIVTRTTCVYWAPN----YERCLLRETPKHGNILDILTASLILASVLFDILVYIF 617
            ...:|..:.:.::..:|||.|..|    ...|.:.:..|..::|..::.:..:.::.|:.|..:.
Mouse   623 LGTIPGPIIFGVIIDSTCVLWDVNECGIKGACWIYDNIKMAHMLVAISVTCKVITIFFNGLAIVL 687

  Fly   618 AK 619
            .|
Mouse   688 YK 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	158/650 (24%)
		MFS	50..>267	CDD:119392	53/250 (21%)
		KAZAL_SLC21	430..483	CDD:238650	17/52 (33%)
Slco4c1	NP_766246.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81
		OATP	102..662	CDD:281175	147/605 (24%)
		MFS	120..>473	CDD:119392	87/390 (22%)
		KAZAL_SLC21	496..549	CDD:238650	18/55 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810