DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and Slco6b1

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_596903.1	Gene:	Slco6b1 / 170925	RGDID:	620278	Length:	748	Species:	Rattus norvegicus

Alignment Length:	694	Identity:	161/694 - (23%)
Similarity:	259/694 - (37%)	Gaps:	154/694 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NTRNSDLSQIAVNANNIPDDSVDCGIKGLGWCRGPGCQKYARLRTFILVLAISGTLQGACESYFR 68
            |..:...||:   ::.||.| :| |..|||....|..|::..:..|::...|....||
  Rat   105 NANSETSSQL---SDKIPTD-LD-GPFGLGSLVVPSLQRFNNINFFLISFCILTLAQG------- 157

  Fly    69 VSAKQASFQFGWNPLIV-----DW---------LLVASGLFQAVFALAFAYWADVYHPIKWLVGT 119
                   ..||...|.:     |:         |..|..|...:..:..|::.......:|:...
  Rat   158 -------IVFGLTDLSIGNFERDFYLSHPEKILLTTAYDLSSLLVVIIVAHYGGRGRRSRWVATA 215

  Fly   120 LMLQAVTCVVAVIP----SIMNFAD--GNQAKDALLDANMCATSLAQFQRLTLTEAQS----SSL 174
            ..|..:..::..:|    .:::..:  |...||.              ::.|:...:.    .|.
  Rat   216 AFLVGLGSIIGALPYLKYEVIHPVEETGELCKDE--------------EQRTMPNCEKIIPFKSE 266

  Fly   175 TLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDSPAVIGAALAARVFGQQAGSFLVLGVGLTH 239
            .:.:..:.|...|...:..|.||::||.||         |.:.||....|....|| |||.||.:
  Rat   267 IIYLSVIGQCFQGFASMPMYVLGMTYIYDN---------ISSYLAGIYLGIADASF-VLGYGLGY 321

  Fly   240 -VG---------------------WW-------------LGWVILAPFIFVGAVLLGLFPKRLPK 269
             ||                     ||             |.|..:.|.:        .||.|||.
  Rat   322 AVGSPNLRPSLNHSSEEKVNDNFLWWQFNWFLGFFSATLLAWFTVFPLL--------CFPHRLPG 378

  Fly   270 T----VIHQAAQRIIEQSSMRRFGSQFSTYMDDSDFWPSLKRLFNNRLLMFNLLSIMCVQSAVVN 330
            :    |..:......::....::|..|      .|...:|..|..|.|||  ..|:.....::..
  Rat   379 SNKLRVWKENEPFFYKKYKDLKYGYSF------QDLLRALWYLVKNPLLM--CYSMCKATESLAL 435

  Fly   331 YGLQEESYLQSRFFLP-YNEQDGLAAEWRSAFVSYFLKPPVMALGMLISGLVISKAKLSARKITG 394
            .|..|        ||| |.|...|.:...:|.::..:..|..|:|..:.|.::||.|:|.:....
  Rat   436 IGATE--------FLPKYLENQFLLSPSSAALLTGIILIPGGAIGNFLGGFIVSKMKMSCKTQMR 492

  Fly   395 INIALSIHLVAIFIGLIFVQCDVGAIAGV----EG----GKLKQPYCSSQCLCTPTAFMPVCPEN 451
            .....|:..:.:|:...||:|:....||:    ||    |.|..| |::.|.||...:..:|..:
  Rat   493 FITVTSVISLLLFVLNAFVKCERVKFAGINSDYEGSGTLGNLTAP-CNAHCGCTSHTYYAICGRD 556

  Fly   452 SSVTYFSPCYAGCTKKTTINSFQLFEGCSCSGDQSLNSTGQ---MRATAGACSSDNCQSAIIIFQ 513
             .:.|||||:|||.....:|..:....|||......|:..:   :.|..|.|:: .|.:..:.|.
  Rat   557 -EIEYFSPCFAGCLNSKELNYEKTLYNCSCIKHGLANADSENDPIDAFLGKCNT-KCYALPLFFA 619

  Fly   514 IMSISVAFLMGVGAIGKTLITLRAVLPQDKSLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYWA 578
            ....|:.| ....:|..|||.||.:.....||.||....|:.:|..:|..|.:.|.:.::|.||.
  Rat   620 FFFSSIVF-SSSASIPITLIILRTLPTSLHSLGLAVTYTILRIFGSIPGPLLFRIASSSSCSYWD 683

  Fly   579 PNYERCLLR------ETPKHGNILDILTASLILASVLFDILVYI 616
            .|  :|.||      ...|..:||..|..|..|.|.|..:|..:
  Rat   684 IN--KCGLRGHCWIYNKFKMMSILMGLCISCKLISTLLSLLALL 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	156/675 (23%)
		MFS	50..>267	CDD:119392	48/275 (17%)
		KAZAL_SLC21	430..483	CDD:238650	18/52 (35%)
Slco6b1	NP_596903.1	OATP	144..701	CDD:281175	139/624 (22%)
		MFS	146..>510	CDD:119392	81/425 (19%)
		KAZAL_SLC21	534..587	CDD:238650	19/54 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810