DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and Slco3a1

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_803434.1	Gene:	Slco3a1 / 140915	RGDID:	620227	Length:	710	Species:	Rattus norvegicus

Alignment Length:	714	Identity:	169/714 - (23%)
Similarity:	276/714 - (38%)	Gaps:	190/714 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RNSDLSQIAVNANNIPDDSVDCGIKGLGWCRGPGCQKYARLRTFI-----LVLAISGTLQGACES 65
            |:.:|.......|......|.|               ::.::.|:     |:||     ||...:
  Rat    14 RSGELQGDEAQRNKKKKKKVSC---------------FSNIKIFLVSECALMLA-----QGTVGA 58

  Fly    66 YF---------RVSAKQA-------SFQFGWNPLIV-----------DWLLVASGLFQAVFALAF 103
            |.         |.:.:.|       ||:.|...||:           ..|:...|:..|:.||..
  Rat    59 YLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLS 123

  Fly   104 AYWADVYHPIKWLVGTLMLQAVTCVVAVIPSIMNFADGNQAKDALLDANMCATSLAQFQR----- 163
            |....:.|..|:..|.:..                  |.:.:|      :|||:.:....
  Rat   124 ALPEFLTHQYKYEAGEIRW------------------GAEGRD------VCATNGSSSDEGPDPD 164

  Fly   164 LTLTEAQSSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDSPAVIGAALAARVFGQQAG 228
            |......::::...:|...|:.||:|......||||||||:...:||...||......|||...|
  Rat   165 LICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACG 229

  Fly   229 SFLVLGVGLTHV-----------------------GWWLGWVILAPFIFVGAVLLGLFPKRLPKT 270
              .:||...|.:                       .||.|:::....:|..::|:..||:.||.
  Rat   230 --FILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPP- 291

  Fly   271 VIHQAAQRIIEQSSM--RRF----------------GSQFSTYMDDSDFWPSLKRLFNNRLLMFN 317
              |.......||:.:  |.:                .|..|.:..........|.|.:|.:....
  Rat   292 --HSEPGMESEQAMLPEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCI 354

  Fly   318 LLSIMCVQSAVV-NYGLQEESYLQSRFFL---PYNEQDGLAAEWRSAFVSYFLKPPVMALGMLIS 378
            :|: .|::.||| .:......||:.:|.|   ..|:..|:.|            .|...||:.:.
  Rat   355 VLA-ACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTA------------IPCACLGIFLG 406

  Fly   379 GLVISKAKLSARKITGINIALSIHLV--AIFIGLIFVQCDVGAIAGV---------EGGKLKQPY 432
            ||::.|..|||  :..|.:|:.::||  |.::..:|:.||...:|||         .|..| .||
  Rat   407 GLLVKKLSLSA--LGAIRMAMLVNLVSTACYVSFLFLGCDTVPVAGVTVRYGNNSARGSPL-DPY 468

  Fly   433 --CSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLFEGCSCSGDQSLNSTGQMRA 495
              |::.|.|...:|.|||..: .:||.|.|:|||      ||..| .||:|     |.:.....|
  Rat   469 SPCNNNCECQTDSFTPVCGAD-GITYLSACFAGC------NSTNL-TGCAC-----LTTVPPENA 520

  Fly   496 TA--GACSSDNCQSAIIIFQIMSISVAFLMGVGAIGKT---LITLRAVLPQDKSLALAFELMIVG 555
            |.  |.|.|..||.|.:.| :..:.|..|  :||:.:|   :|.:|.|.|:.||.||....:::.
  Rat   521 TVVPGKCPSPGCQEAFLTF-LCVMCVCSL--IGAMAQTPSVIILIRTVSPELKSYALGVLFLLLR 582

  Fly   556 LFAYVPVHLSYDIVTRTTCVYWAP---NYERCLLRETPKHGNIL-DILTASLILASVLFDILVY 615
            |..::|..|.:.....:||::|:.   ....|:|     :.|:: ..|..|:.:|...|..::|
  Rat   583 LLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVL-----YDNVVYRYLYVSIAIALKSFAFILY 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	166/697 (24%)
		MFS	50..>267	CDD:119392	59/276 (21%)
		KAZAL_SLC21	430..483	CDD:238650	22/54 (41%)
Slco3a1	NP_803434.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		2/10 (20%)
		OATP	41..619	CDD:281175	158/648 (24%)
		MFS	47..>286	CDD:119392	57/269 (21%)
		KAZAL_SLC21	467..511	CDD:238650	21/51 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339166
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740