Protein Alignment Oatp33Eb and SLCO6A1

DIOPT Version :10

• Sequence 1: NP_609570.1
• Gene: Oatp33Eb / 34662
• FlyBaseID: FBgn0032435
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_775759.3
• Gene: SLCO6A1 / 133482
• HGNCID: 23613
• Length: 719
• Species: Homo sapiens
• Alignment Length: 686
• Identity: 152/686 - (22%)
• Similarity: 269/686 - (39%)
• Gaps: 123/686 - (17%)

  Fly    22 DDSVD--CGIKGLGWCRGPGCQKYARLRTFILVLAISGTLQGACESYFRVSAKQASFQFGWNPLI 84
            |||::  |   |||......|:....:|.|::...|....||.......||.  ..||..:....
Human    82 DDSLEQPC---GLGCLVSTCCECCNNIRCFMIFYCILLICQGVVFGLIDVSI--GDFQKEYQLKT 141

  Fly    85 VDWLL------VASGLFQAVFALAFAYWADVYHPIKWLVGTLMLQAVTCVVAVIPSIMNFADGNQ 143
            ::.|.      ::|||    .|:..|::.| ...:.|.|.:..|..:..::...|||..  :..|
Human   142 IEKLALEKSYDISSGL----VAIFIAFYGD-RKKVIWFVASSFLIGLGSLLCAFPSINE--ENKQ 199

  Fly   144 AKDALLD-------ANMCATSLAQFQRLTLTEAQSSSLTLAMLFVL-QLALGMGGLAYYTLGVSY 200
            :|..:.|       .:.|.:|...||...|:           .|:| |...|:.|:..|.||:::
Human   200 SKVGIEDICEEIKVVSGCQSSGISFQSKYLS-----------FFILGQTVQGIAGMPLYILGITF 253

  Fly   201 IDDNSLSQDSPAVIGAALAARVFGQQAGSFLVLGVGLTHV---------------------GWWL 244
            ||:|..:..:...:|.|....:.|...|  .|||..|..|                     .||:
Human   254 IDENVATHSAGIYLGIAECTSMIGYALG--YVLGAPLVKVPENTTSATNTTVNNGSPEWLWTWWI 316

  Fly   245 GWVILAPFIFVGAVLLGLFPKRLPKTVIHQAAQRIIEQSSMRRFGS-----QFSTYMDD--SDFW 302
            .::..|...:...:.|..||..:|.:...:|.:|    ..:..|.|     :..|.:.|  :..|
Human   317 NFLFAAVVAWCTLIPLSCFPNNMPGSTRIKARKR----KQLHFFDSRLKDLKLGTNIKDLCAALW 377

  Fly   303 PSLKRLFNNRLLMFNLLSIMCVQSAVVNY----GLQE--ESYLQSRFFLPYNEQDGLAAEWRSAF 361
                      :||.|.:.|....|....|    |..|  ..||:::|.|.......||.
Human   378 ----------ILMKNPVLICLALSKATEYLVIIGASEFLPIYLENQFILTPTVATTLAG------ 426

  Fly   362 VSYFLKPPVMALGMLISGLVISKAKLSARKITGINIALSIHLVAIFIGLIFVQCDVGAIAGV--- 423
               .:..|..|||.|:.|:::|..::|.:.:....:..|:..:.:.:.:|||:|:....||:
Human   427 ---LVLIPGGALGQLLGGVIVSTLEMSCKALMRFIMVTSVISLILLVFIIFVRCNPVQFAGINED 488

  Fly   424 -EG----GKLKQPYCSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLFEGCSCSG 483
             :|    |.|..| |:.:|.|:.:.:..:|..: .:.|||||:||||.....|..:::..|||..
Human   489 YDGTGKLGNLTAP-CNEKCRCSSSIYSSICGRD-DIEYFSPCFAGCTYSKAQNQKKMYYNCSCIK 551

  Fly   484 DQSLNSTGQ---MRATAGACSSDNCQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVLPQDKSL 545
            :..:.:..:   :.|..|.|.: .|.. :.:|.....|.....|...:...|...|.|..:.:||
Human   552 EGLITADAEGDFIDARPGKCDA-KCYK-LPLFIAFIFSTLIFSGFSGVPIVLAMTRVVPDKLRSL 614

  Fly   546 ALAFELMIVGLFAYVPVHLSYDIVTRTTCVYWAPN----YERCLLRETPKHGNILDILTASLILA 606
            ||....:|:.:|..:|....:.:...|:|:....|    ..||.:....|...:|..:.....|.
Human   615 ALGVSYVILRIFGTIPGPSIFKMSGETSCILRDVNKCGHTGRCWIYNKTKMAFLLVGICFLCKLC 679

  Fly   607 SVLFDILVYIFAKGLNLYNCKVTDNNYTPSLYAPIP 642
            :::|..:.:.      :|..::.:|...|.:....|
Human   680 TIIFTTIAFF------IYKRRLNENTDFPDVTVKNP 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	MFS_SLCO_OATP	46..536	CDD:340894	122/548 (22%)
		PHA03247	<635..813	CDD:223021	2/8 (25%)
SLCO6A1	NP_775759.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46
		MFS_SLCO6_OATP6	105..605	CDD:340963	122/548 (22%)