Protein Alignment Oatp33Eb and SLCO2B1

DIOPT Version :9

• Sequence 1: NP_609570.1
• Gene: Oatp33Eb / 34662
• FlyBaseID: FBgn0032435
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: XP_016872646.1
• Gene: SLCO2B1 / 11309
• HGNCID: 10962
• Length: 711
• Species: Homo sapiens
• Alignment Length: 649
• Identity: 154/649 - (23%)
• Similarity: 268/649 - (41%)
• Gaps: 149/649 - (22%)

  Fly    43 YARLRTFILV--------LAISGTLQGA---CESYFRVSAKQ----ASFQFGWNPLIVDWLLVAS 92
            :..::.|:|.        |.|||.|:.:   .|..|.:|::.    |||....|..::
Human    47 FHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALI------- 104

  Fly    93 GLFQAVFALAFAYWADVYHPIKWLVGTLMLQAVTCVVAVIPSIMNFA---DGNQAKDALLD--AN 152
                 ||.   :|:....|..:.:....:|.|:..::..:|..::..   |....:|...|  |:
Human   105 -----VFV---SYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKAS 161

  Fly   153 MC-------ATSLAQFQRLTLTEAQSSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDS 210
            :|       |::.:.....:.||.|..|: :.::||.|..||:||:.....|:|||||.:.:.:|
Human   162 LCLPTTSAPASAPSNGNCSSYTETQHLSV-VGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNS 225

  Fly   211 PAVIGAALAARVFGQ----QAGSFLVL-----------GVGLT-----HVG-WWLGWVILAPFIF 254
            |..:|...|..:.|.    ..||.::.           |:.||     .|| ||||::|.|..:.
Human   226 PLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVA 290

  Fly   255 VGAVLLGLFPKRLPK------------TVIHQAAQRIIEQSSMRRFGSQFSTYMDDS--DFWPSL 305
            :.|:....|||.:||            .|....|::..:..|.:..|.  ||...|.  ...|:|
Human   291 LAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGE--STKKQDGLVQIAPNL 353

  Fly   306 K-----RLFNNRLL--------MFNLLSIMCVQSAVVNYGLQEESYLQSRFFLPYNEQDGLAAEW 357
            .     ::|...||        :..:||.:|:.|...........:|:.:|        .:.|.:
Human   354 TVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQF--------SITASY 410

  Fly   358 RSAFVSYFLKPPVMALGMLISGLVISKAKL-----SARKITGINIALSIHLVAIFIGLIFVQCDV 417
            .:..:.....|.|: :|:::.|:::.:..|     .|..:.|:.:.|...|...|||     |..
Human   411 ANLLIGCLSFPSVI-VGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIG-----CSS 469

  Fly   418 GAIAGV------EGGKLKQPYCSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTK---KTTINSF 473
            ..|||:      ..|....|.|...|.|....|.|||..::.|.|.:||:|||:.   :..:::.
Human   470 HQIAGITHQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNS 534

  Fly   474 QLF-EGCSC--SGDQSLNSTGQMRATAGACSSDNCQSAIIIFQIMSISVAFLMGVGAIGKT---L 532
            |:| ..|||  .|:..|         ||:|.| .|...::.|.::   |:....:..:..|   :
Human   535 QVFYTNCSCVVEGNPVL---------AGSCDS-TCSHLVVPFLLL---VSLGSALACLTHTPSFM 586

  Fly   533 ITLRAVLPQDKSLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYWAPN---------YERCLLR 587
            :.||.|..:||:||:..:.|.:.:.|::|..:.:.....||||:||.:         |...|||
Human   587 LILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLR 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	154/649 (24%)
		MFS	50..>267	CDD:119392	65/264 (25%)
		KAZAL_SLC21	430..483	CDD:238650	20/58 (34%)
SLCO2B1	XP_016872646.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740