DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and Slco3a1

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_076397.2	Gene:	Slco3a1 / 108116	MGIID:	1351867	Length:	710	Species:	Mus musculus

Alignment Length:	713	Identity:	167/713 - (23%)
Similarity:	277/713 - (38%)	Gaps:	188/713 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RNSDLSQIAVNANNIPDDSVDCGIKGLGWCRGPGCQKYARLRTFI-----LVLAISGTLQGACES 65
            |:.:|.......|......|.|               ::.::.|:     |:||     ||...:
Mouse    14 RSGELQGDEAQRNKKKKKKVSC---------------FSNIKIFLVSECALMLA-----QGTVGA 58

  Fly    66 YF---------RVSAKQA-------SFQFGWNPLIV-----------DWLLVASGLFQAVFALAF 103
            |.         |.:.:.|       ||:.|...||:           ..|:...|:..|:.||..
Mouse    59 YLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLS 123

  Fly   104 AYWADVYHPIKWLVGTLMLQAVTCVVAVIPSIMNFADGNQAKDALLDANMCATSLAQFQR----- 163
            |....:.|..|:..|.:..                  |.:.:|      :|||:.:....
Mouse   124 ALPEFLTHQYKYEAGEIRW------------------GAEGRD------VCATNGSSSDEGPDPD 164

  Fly   164 LTLTEAQSSSLTLAMLFVLQLALGMGGLAYYTLGVSYIDDNSLSQDSPAVIGAALAARVFGQQAG 228
            |......::::...:|...|:.||:|......||||||||:...:||...||......|||...|
Mouse   165 LICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACG 229

  Fly   229 SFLVLGVGLTHV-----------------------GWWLGWVILAPFIFVGAVLLGLFPKRLPKT 270
              .:||...|.:                       .||.|:::....:|..::|:..||:.||.
Mouse   230 --FILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPP- 291

  Fly   271 VIH-----QAAQRIIEQSSMRR-------------FGSQFSTYMDDSDFWPSLKRLFNNRLLMFN 317
              |     ::.|.::.:....|             ..|..|.:..........|.|.:|.:....
Mouse   292 --HSDPGMESEQAMLPEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCI 354

  Fly   318 LLSIMCVQSAVV-NYGLQEESYLQSRFFL---PYNEQDGLAAEWRSAFVSYFLKPPVMALGMLIS 378
            :|: .|::.||| .:......||:.:|.|   ..|:..|:.|            .|...||:.:.
Mouse   355 VLA-ACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTA------------IPCACLGIFLG 406

  Fly   379 GLVISKAKLSARKITGINIALSIHLV--AIFIGLIFVQCDVGAIAGV--------EGGKLKQPY- 432
            ||::.|..|||  :..|.:|:.::||  |.::..:|:.||.|.:|||        ..|....||
Mouse   407 GLLVKKLSLSA--LGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVRYGNNSARGSALDPYS 469

  Fly   433 -CSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLFEGCSCSGDQSLNSTGQMRAT 496
             |::.|.|...:|.|||..: .:||.|.|:|||      ||..| .||:|     |.:.....|:
Mouse   470 PCNNNCECQTDSFTPVCGAD-GITYLSACFAGC------NSTNL-TGCAC-----LTTVPPENAS 521

  Fly   497 A--GACSSDNCQSAIIIFQIMSISVAFLMGVGAIGKT---LITLRAVLPQDKSLALAFELMIVGL 556
            .  |.|.|..||.|.:.| :..:.|..|  :||:.:|   :|.:|.|.|:.||.||....:::.|
Mouse   522 VVPGKCPSPGCQEAFLTF-LCVMCVCSL--IGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRL 583

  Fly   557 FAYVPVHLSYDIVTRTTCVYWAP---NYERCLLRETPKHGNIL-DILTASLILASVLFDILVY 615
            ..::|..|.:.....:||::|:.   ....|:|     :.|:: ..|..|:.:|...|..::|
Mouse   584 LGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVL-----YDNVVYRYLYVSIAIALKSFAFILY 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	164/696 (24%)
		MFS	50..>267	CDD:119392	59/276 (21%)
		KAZAL_SLC21	430..483	CDD:238650	22/54 (41%)
Slco3a1	NP_076397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		2/10 (20%)
Slco3a1	NP_076397.2	MFS_SLCO3_OATP3	39..563	CDD:340960	141/588 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835541
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740