DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Eb and Slco4a1

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001342147.1	Gene:	Slco4a1 / 108115	MGIID:	1351866	Length:	723	Species:	Mus musculus

Alignment Length:	717	Identity:	179/717 - (24%)
Similarity:	305/717 - (42%)	Gaps:	136/717 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RNSDLSQIAVNANNIPDDSVDCGIKGLGWCRGPGC-QKYARLRTFILVLAISGTLQG-------- 61
            |:|..::.....::.|.:|: ||.:..    .|.| |.:...:.|:..|..:..|||
Mouse    65 RSSQTAREVQYVSSGPQNSL-CGWQAF----TPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFIN 124

  Fly    62 ----ACESYFRVSAKQASFQFGWNPLIVDWLLVASGLFQAVFALAF-AYWADVYHPIKWLVGTLM 121
                :.|..|.:.    |:|.|        |:.:|....|...|.| :|:....|..:||...::
Mouse   125 TVITSIERRFDLH----SYQSG--------LIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGVL 177

  Fly   122 LQAVTCVVAVIPSIMNFADGNQ--AKDALLDANMCATSLAQFQRLTLTEAQSSSLTLA---MLFV 181
            :..:..:|..:|   :|..|..  ..|..|....|.|:.:.      .|.:.|:..|:   ::|:
Mouse   178 VLGIGSLVFALP---HFTAGRYEVEMDEGLGTGTCLTNQSH------VECKDSASGLSNYRLIFM 233

  Fly   182 L-QLALGMGGLAYYTLGVSYIDDNSLSQDSPAVIGAALAARVFGQQAGSFLVLGVGL---THVG- 241
            | ||..|:|....|||||:|:|:|..|..||..|.....|.:.|..|| :|:.|..|   |.||
Mouse   234 LGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAG-YLIGGAMLNVYTEVGQ 297

  Fly   242 --------------WWLGWVILAPFIFVGAV-LLGLFPKRLP---KTVIHQAA--QRIIEQS--- 283
                          ||:|::......|:.|: :|| :|::||   :.|:.:||  |::.:.|
Mouse   298 RTELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILG-YPRQLPGSQRYVVMRAAETQQLKDHSRGA 361

  Fly   284 -SMRRFGSQFSTYMD-DSDFWPSLKRLFNNRLLMFN-LLSIMCVQSAVVNYGLQEESYLQSRFFL 345
             |...||   .|..| ....|          ||:.| ...::|:..|.....:...|....:||
Mouse   362 VSNPAFG---KTVRDLPLSIW----------LLLRNPTFILLCLAGATEATLIAGMSTFGPKFF- 412

  Fly   346 PYNEQDGLAAEWRSAFVSYFLKPPVMALGMLISGLVISKAKLSARKITGINIALSIHLVAIFIGL 410
              ..|..|:|...:....| |..|....|.|:.|.:::|.||....|  |...|...|.::....
Mouse   413 --EAQFSLSASEAATLFGY-LVVPAGGGGTLLGGFLVNKFKLRGSGI--IRFCLFCTLTSLLAFF 472

  Fly   411 IF-VQCDVGAIAGVEGG-----------KLKQPYCSSQCLCTPTAFMPVCPENSSVTYFSPCYAG 463
            :| :.|....:|||..|           .||.. |::...|.|..:.|:|..:.:: |:||||||
Mouse   473 VFLMHCPNVHMAGVTTGYVGSLLPKGQLDLKAA-CNAIYCCQPKHYSPLCGSDGTM-YYSPCYAG 535

  Fly   464 C--TKKTTINSFQLFEGCSCSGDQSLNSTGQMRATAGACSSDNCQSA--IIIFQIMSISVAFLMG 524
            |  ..:|.:...:::.||||..:::  |:|...||||.|:| .|||.  :::...:.|...||..
Mouse   536 CPADAETDLGGQKVYRGCSCILEKA--SSGWGNATAGKCAS-TCQSKPFLLVLVFVVIIFTFLSS 597

  Fly   525 VGAIGKTLITLRAVLPQDKSLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYW---APNYERCLL 586
            :.|:   ..|||.|..:.:|.||..:.::|.....:|..:::..|....|:.|   ..:...|.:
Mouse   598 IPAL---TATLRCVSDRQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFV 659

  Fly   587 RETPKHGNILDILTASLILASVLFDILVYI-FAKGLNLYNCKVTDNNYTPSLYAPIPHE-DATTS 649
            .|.       :.::..:::|.:.|.:|.:: |.....||......::   .|.|.:|.: .|:.|
Mouse   660 YEN-------EAMSRYMLIAGLTFKVLGFLFFVAAYFLYKSPSVSSD---GLEASLPSQSSASDS 714

  Fly   650 PS 651
            |:
Mouse   715 PT 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	168/665 (25%)
		MFS	50..>267	CDD:119392	65/254 (26%)
		KAZAL_SLC21	430..483	CDD:238650	18/54 (33%)
Slco4a1	NP_001342147.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..64
		OATP	103..665	CDD:308646	158/618 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..723		6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4629
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.760