Protein Alignment Oatp33Eb and SLCO1B1

DIOPT Version :10

• Sequence 1: NP_609570.1
• Gene: Oatp33Eb / 34662
• FlyBaseID: FBgn0032435
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_006437.3
• Gene: SLCO1B1 / 10599
• HGNCID: 10959
• Length: 691
• Species: Homo sapiens
• Alignment Length: 686
• Identity: 153/686 - (22%)
• Similarity: 273/686 - (39%)
• Gaps: 135/686 - (19%)

  Fly    34 WCRGPGCQKYARLRTFILVLAIS---GTLQGA---------CESYFRVSAKQASFQFGWNPLIVD 86
            :|.|        |:.|:..|::|   .|| ||         .|..|.:|:....|        :|
Human    23 YCNG--------LKMFLAALSLSFIAKTL-GAIIMKSSIIHIERRFEISSSLVGF--------ID 70

  Fly    87 WLLVASGLFQAVFALAFAYWADVYHPIKWLVGTLMLQAVTCVV----AVIPSIMNFADG--NQAK 145
            .......|...||.   :|:....|..| |:|      :.|.:    .|:.::.:|..|  ..:|
Human    71 GSFEIGNLLVIVFV---SYFGSKLHRPK-LIG------IGCFIMGIGGVLTALPHFFMGYYRYSK 125

  Fly   146 DALLDANMCATSLAQF----QRLTLTEA-----------QSSSLTLAMLFVLQLALGMGGLAYYT 195
            :..::::..:||....    |.|:|..|           :|.|.....:|:..:..|:|......
Human   126 ETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVP 190

  Fly   196 LGVSYIDDNSLSQDSPAVIG----AALAARVFGQQAGS-FLVLGVGLTHV--------------- 240
            ||:|||||.:....|...:|    .|:...:.|...|| |..:.|.:.:|
Human   191 LGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWV 255

  Fly   241 -GWWLGWVILAPFIFVGAVLLGLFPKRLPKTVIHQAAQ---RIIE-------QSSMRRFGSQFST 294
             .|||.:::...|..:.::.....|:...|....:.|.   .::|       .:::...|...:.
Human   256 GAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITK 320

  Fly   295 YMDDSDFWPSLKRLFNNRL-LMFNLLSIMCVQSAVVNYGLQEESYLQS-RFFLPYNEQDGLAAEW 357
            .:  :.|:.|.|.:..|.| :||.||::           ||..||:.: .:...|.||.......
Human   321 NV--TGFFQSFKSILTNPLYVMFVLLTL-----------LQVSSYIGAFTYVFKYVEQQYGQPSS 372

  Fly   358 RSAFVSYFLKPPVMALGMLISGLVISKAKLSARKITGINIALSIHLVAIFIGLIFVQCDVGAIAG 422
            ::..:...:..|:.|.||.:.|.:|.|.||:...|...:...::..::.::...|:.|:..::||
Human   373 KANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAG 437

  Fly   423 V----EGGK-------LKQPYCSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLF 476
            :    :|..       :...||:|.|.|..:.:.||| .|:.:||.|||.|||...:......:|
Human   438 LTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVC-GNNGITYISPCLAGCKSSSGNKKPIVF 501

  Fly   477 EGCSC---SGDQSLNSTGQMRATAGACSSDN-CQSAIIIFQIMSISVAFLMGVGAIGKTLITLRA 537
            ..|||   :|.|:.|.:..:    |.|..|: |......|..:.:...|...:|.....::.::.
Human   502 YNCSCLEVTGLQNRNYSAHL----GECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKI 562

  Fly   538 VLPQDKSLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYWAPNYERCLLRETPKHGNILDILTAS 602
            |.|:.|||||.|..|::.....:...:.:..:..|||:.|:.|  .|..|.:.:..|........
Human   563 VQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTN--NCGTRGSCRTYNSTSFSRVY 625

  Fly   603 LILAS-------VLFDILVYIFAKGLNLYNCKVTDN 631
            |.|:|       ||:.||:|...|.....:...::|
Human   626 LGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASEN 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	MFS_SLCO_OATP	46..536	CDD:340894	124/570 (22%)
		PHA03247	<635..813	CDD:223021
SLCO1B1	NP_006437.3	MFS	27..561	CDD:475125	124/570 (22%)