DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Eb and SLCO1B1

DIOPT Version :9

Sequence 1:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_006437.3	Gene:	SLCO1B1 / 10599	HGNCID:	10959	Length:	691	Species:	Homo sapiens

Alignment Length:	686	Identity:	153/686 - (22%)
Similarity:	273/686 - (39%)	Gaps:	135/686 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 WCRGPGCQKYARLRTFILVLAIS---GTLQGA---------CESYFRVSAKQASFQFGWNPLIVD 86
            :|.|        |:.|:..|::|   .|| ||         .|..|.:|:....|        :|
Human    23 YCNG--------LKMFLAALSLSFIAKTL-GAIIMKSSIIHIERRFEISSSLVGF--------ID 70

  Fly    87 WLLVASGLFQAVFALAFAYWADVYHPIKWLVGTLMLQAVTCVV----AVIPSIMNFADG--NQAK 145
            .......|...||.   :|:....|..| |:|      :.|.:    .|:.::.:|..|  ..:|
Human    71 GSFEIGNLLVIVFV---SYFGSKLHRPK-LIG------IGCFIMGIGGVLTALPHFFMGYYRYSK 125

  Fly   146 DALLDANMCATSLAQF----QRLTLTEA-----------QSSSLTLAMLFVLQLALGMGGLAYYT 195
            :..::::..:||....    |.|:|..|           :|.|.....:|:..:..|:|......
Human   126 ETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVP 190

  Fly   196 LGVSYIDDNSLSQDSPAVIG----AALAARVFGQQAGS-FLVLGVGLTHV--------------- 240
            ||:|||||.:....|...:|    .|:...:.|...|| |..:.|.:.:|
Human   191 LGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWV 255

  Fly   241 -GWWLGWVILAPFIFVGAVLLGLFPKRLPKTVIHQAAQ---RIIE-------QSSMRRFGSQFST 294
             .|||.:::...|..:.::.....|:...|....:.|.   .::|       .:::...|...:.
Human   256 GAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITK 320

  Fly   295 YMDDSDFWPSLKRLFNNRL-LMFNLLSIMCVQSAVVNYGLQEESYLQS-RFFLPYNEQDGLAAEW 357
            .:  :.|:.|.|.:..|.| :||.||::           ||..||:.: .:...|.||.......
Human   321 NV--TGFFQSFKSILTNPLYVMFVLLTL-----------LQVSSYIGAFTYVFKYVEQQYGQPSS 372

  Fly   358 RSAFVSYFLKPPVMALGMLISGLVISKAKLSARKITGINIALSIHLVAIFIGLIFVQCDVGAIAG 422
            ::..:...:..|:.|.||.:.|.:|.|.||:...|...:...::..::.::...|:.|:..::||
Human   373 KANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAG 437

  Fly   423 V----EGGK-------LKQPYCSSQCLCTPTAFMPVCPENSSVTYFSPCYAGCTKKTTINSFQLF 476
            :    :|..       :...||:|.|.|..:.:.||| .|:.:||.|||.|||...:......:|
Human   438 LTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVC-GNNGITYISPCLAGCKSSSGNKKPIVF 501

  Fly   477 EGCSC---SGDQSLNSTGQMRATAGACSSDN-CQSAIIIFQIMSISVAFLMGVGAIGKTLITLRA 537
            ..|||   :|.|:.|.:..:    |.|..|: |......|..:.:...|...:|.....::.::.
Human   502 YNCSCLEVTGLQNRNYSAHL----GECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKI 562

  Fly   538 VLPQDKSLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYWAPNYERCLLRETPKHGNILDILTAS 602
            |.|:.|||||.|..|::.....:...:.:..:..|||:.|:.|  .|..|.:.:..|........
Human   563 VQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTN--NCGTRGSCRTYNSTSFSRVY 625

  Fly   603 LILAS-------VLFDILVYIFAKGLNLYNCKVTDN 631
            |.|:|       ||:.||:|...|.....:...::|
Human   626 LGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASEN 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	151/672 (22%)
		MFS	50..>267	CDD:119392	56/270 (21%)
		KAZAL_SLC21	430..483	CDD:238650	21/55 (38%)
SLCO1B1	NP_006437.3	OATP	29..621	CDD:281175	140/630 (22%)
		MFS	31..>427	CDD:119392	86/427 (20%)
		KAZAL_SLC21	455..508	CDD:238650	21/53 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810