Protein Alignment Oatp33Ea and Slco1a6

DIOPT Version :10

• Sequence 1: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: XP_063142836.1
• Gene: Slco1a6 / 84608
• RGDID: 69304
• Length: 690
• Species: Rattus norvegicus
• Alignment Length: 753
• Identity: 174/753 - (23%)
• Similarity: 289/753 - (38%)
• Gaps: 158/753 - (20%)

  Fly    31 YATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIG 95
            :|..|:|:.........:|:|..|....||.:|:||.|.:...|:|....|:..::|.:.:||.|
  Rat    36 FAKIKVFLLALTWAYASKALSATYMNSMLTQIERRFNISTSIVGLINGSFEVGNLLLIIFVSYFG 100

  Fly    96 GQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVK 160
            .:|:||..|..|....||.|:|:.||||:.|        ..||:.::...:..|.:||
  Rat   101 RKRHRPIMIGIGCAVMGLGCFIISLPHFLMG--------RYEYETTISPTSNLSSNSF------- 150

  Fly   161 TERLCGVDKTED--------DCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNT 217
               ||..::|:.        :|......:..:.:.:...:.|:|.|....||.:|::|..|..|:
  Rat   151 ---LCMENRTQTLKPTQDPAECVKEMKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENS 212

  Fly   218 PLMLAVAMALRMIGPVVGFFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVILGTLMC 278
            |..:.:....::.||:...:.|......::|    .|....|...|.|.:||||:|:::...|..
  Rat   213 PFYIGILEVGKITGPIAAIWLGSFCATIYVDMGSVNTDDLTITPTDTRCVGAWWIGFLVCAGLNI 277

  Fly   279 LFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANA 343
            |.|.....|||..||               :..|::..|.......:....|..:..|..
  Rat   278 LISIPFFFFPKTFPK---------------EGPEDMANETKNDEGDKHREKAKEEKRGIT----- 322

  Fly   344 DLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPIS 408
                 |||...:..|..|.:.:..:|::|..:.|.....||..||:|..:.|.:..|..::|..:
  Rat   323 -----KDFFLFMKSLSCNPIYMLCVLTSVLQVNGFVSIFTFKPKYLEHHYGKSSSEAIFLMGLYT 382

  Fly   409 IMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPN--------------- 458
            :..:.||.:.||.::.|.|.::.|....:..:|....|..:....|.|.|
  Rat   383 LPSVCVGYLISGFIMKKFKITLKKAAFISYCLGMSECLLSLCNFMLTCDNVPIAGLTTSYEGIQQ 447

  Fly   459 TFSMTQAGQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCR-----GYNATSKLYEDC 518
            :|.|    :..:.::||..|||...::.|||.: ....:.:.|.|||.     |.|   .:.:||
  Rat   448 SFDM----ENTVLADCNTRCSCLTKTWDPVCGD-NGLAYITPCLAGCEKSVGSGIN---MVLQDC 504

  Fly   519 SCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDS 583
            ||:                                                        :|:.:|
  Rat   505 SCI--------------------------------------------------------QSSGNS 513

  Fly   584 VIRPGICTK--NCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLL 646
            ....|:|.|  :|......|.|.::..|:|.|...:...::..|.:..|:||...||....:.:|
  Rat   514 SAVLGLCNKGPDCANKLQYFLIITVFCSFFYSLSLIPGYMIFLRCMKSEEKSLGIGLQAFCMRIL 578

  Fly   647 ALIPGPIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYG 710
            ..|..||.||.|||.|||.| |:.|...|.|:.|:...||.....|...|.....|..:.:....
  Rat   579 GGILAPIYFGVLIDRTCLHWGTQKCGEPGACRTYEINSFRSIYLGLPAALRGSSYLPAFFILRLM 643

  Fly   711 RNLDIYGDKEAKEEERANRKDQPITP-----LLAKKSE 743
            |.....||           .:.|:|.     |..|:||
  Rat   644 RKFQFPGD-----------INSPVTDHVEMMLTEKESE 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	158/682 (23%)
Slco1a6	XP_063142836.1	None