Protein Alignment Oatp33Ea and Slco1c1

DIOPT Version :10

• Sequence 1: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_445893.1
• Gene: Slco1c1 / 84511
• RGDID: 628660
• Length: 716
• Species: Rattus norvegicus
• Alignment Length: 713
• Identity: 184/713 - (25%)
• Similarity: 307/713 - (43%)
• Gaps: 154/713 - (21%)

  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99
            |:|:|....:...:|::..|...|:|.:|:||.|||...|||....||..:::...:||.|.:.:
  Rat    43 KVFLGALSFVYFAKALTEGYLKSTITQIERRFDIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLH 107

  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNI-------S 157
            ||:.|..|.:..|....::.:|.|          |.::|........:.|.:...||       |
  Rat   108 RPKIIGAGCLVMGFGTMLIAVPQF----------FMEKYSYEKYERYSPSSNLTPNISPCYLESS 162

  Fly   158 SVKTERLCG--VDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLM 220
            |.....:.|  .:|..|:|:...|....|.:||...:.|:|.|....||..||||...:.|....
  Rat   163 SPSPRSIVGKSQNKINDECEVDTSSSMWVYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFY 227

  Fly   221 LAVAMALRMIGPVVGFFFGFISLNTFID--------PTKTPLIDSKDPRWLGAWWLGWVILGTLM 277
            :.....:.:|||:.||..|.:....::|        .|.||    |||:|:||||||::|.|.|.
  Rat   228 IGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITP----KDPQWVGAWWLGYLIAGFLS 288

  Fly   278 CLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELK-------------REENLSLSSRFSSN 329
            .|.:......||.||: :.||.:|      ..:.|:.|             |||::.:
  Rat   289 LLAAVPFWCLPKTLPR-SQSREDS------GSSSEKSKFITDDPVNYQMAPREESMKI------- 339

  Fly   330 AALDTIGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFH 394
                           :...:||..:|..|.||.:.|..:.::........|.:|:..||:|.|:.
  Rat   340 ---------------MEMARDFLPSLKSLFRNPVYILYLCASTVQFNSLFGMVTYKPKYIEQQYG 389

  Fly   395 KDAQSATIIVGPISIMGMVVGLIGSGMVLSKKKPSV---SKVLMWNVIVGGISILGQISYAFLY- 455
            :.:..|..::|.|:|..:.:|:...|:|:.|.:..:   :|:.:      |.|:.|.:.:..|:
  Rat   390 QSSSKANFVIGLINIPAVALGIFSGGIVMKKFRLGICEATKLYL------GSSVFGYLLFLSLFA 448

  Fly   456 --CPNT----FSMTQAG-------QLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRG 507
              |.|:    .:::..|       :..|.|:||..|.|....:.|:|.: ...|:.|||.|||:.
  Rat   449 LGCENSSVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGD-NGITYASACLAGCQS 512

  Fly   508 YNATSK--LYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDD 570
            .:.:.|  ::.:|:| |...||||                                    |::..
  Rat   513 SSRSGKNIIFSNCTC-VGFAAPKS------------------------------------GNWSG 540

  Fly   571 QLLSRTRRSTSDSVIRPGICTKN--CNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKS 633
            .:               |.|.|:  |:..|..|.:.|:|.|:..|.|.:...::..|.:..:.||
  Rat   541 MM---------------GRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKS 590

  Fly   634 FAQGLALMMISLLALIPGPIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLL 695
            ||.|:..:.:.:||.||.|:.||.|||::||.| .|.|...|:|:|||...||:....|:.||
  Rat   591 FALGIYTLAVRVLAGIPAPVYFGVLIDTSCLKWGFKKCGSRGSCRLYDSHAFRHIYLGLTTLL 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	178/699 (25%)
Slco1c1	NP_445893.1	MFS	42..583	CDD:475125	153/641 (24%)