Protein Alignment Oatp33Ea and Slco1a5

DIOPT Version :9

• Sequence 1: NP_001260417.1
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_110465.1
• Gene: Slco1a5 / 80900
• RGDID: 70985
• Length: 670
• Species: Rattus norvegicus
• Alignment Length: 760
• Identity: 189/760 - (24%)
• Similarity: 305/760 - (40%)
• Gaps: 172/760 - (22%)

  Fly    31 YATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIG 95
            ::..|||:.........:::|.:|....||.:|::|.||:...|.|....||..::|.:.:||.|
  Rat    16 FSKIKMFLLALTWAYVSKSLSGIYMNTMLTQIERQFDIPTSIVGFINGSFEIGNLLLIIFVSYFG 80

  Fly    96 GQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSF---QNIS 157
            .:.:||..|..|.|..||.|:::.||||:.|        ..||:.::...:..|.:||   :|.|
  Rat    81 TKLHRPIMIGVGCVIMGLGCFLMSLPHFLMG--------RYEYETTISPTSNLSSNSFLCMENRS 137

  Fly   158 SVKTERLCGVDKTED--DCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLM 220
            ..       :..|:|  :|......:..:.:.:...:.|:|.|....||.:|::|..|..|:||.
  Rat   138 QT-------LKPTQDPAECIKEMKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLY 195

  Fly   221 LAVAMALRMIGPVVGFFFGFISLNTFIDP----TKTPLIDSKDPRWLGAWWLGWVILGTLMCLFS 281
            :.:....::.||:||...|....:.::|.    |....|...|.||:||||:|::|...:..|.|
  Rat   196 IGILETGKVFGPIVGLLLGSFCASIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLICAGVNILSS 260

  Fly   282 GLIGLFPKQLPK---------VNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGA 337
            .....|||.|||         .|..:...|         .|..:|||..::
  Rat   261 IPFFFFPKTLPKEGLQDDVDGTNNDKEEKH---------REKAKEENRGIT-------------- 302

  Fly   338 AAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATI 402
                       |||...:..|..|.:.:..||::|..|.......|||.||:|.|:.|......:
  Rat   303 -----------KDFLPFMKSLSCNPIYMLLILTSVLQINAFINMFTFLPKYLEQQYGKSTAEVVL 356

  Fly   403 IVGPISIMGMVVGLIGSGMVLSKKKPSVSKV------------LMW---------NVIVGGISIL 446
            ::|..::..:.:|.:..|.::.|.|.:|.|.            |::         |..|.|::..
  Rat   357 LIGVYNLPPICIGYLLIGFIMKKFKITVKKAAYMAFCLSLFEYLLYFLHFMITCDNFPVAGLTAS 421

  Fly   447 GQISYAFLYCPNTFSMTQAGQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGY--N 509
            .:..:..||..|          .:.::||..|||...|:.|||.: ....:.|||.|||:..  .
  Rat   422 YEGVHHPLYVEN----------KVLADCNRGCSCSTNSWDPVCGD-NGLAYMSACLAGCKKSVGT 475

  Fly   510 ATSKLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLS 574
            .|:.::::|||:
  Rat   476 GTNMVFQNCSCI----------------------------------------------------- 487

  Fly   575 RTRRSTSDSVIRPGICTK--NCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQG 637
               ||:.:|....|:|.|  .|......|.|.|:|.|:..|...:...:|..|.:..|:||...|
  Rat   488 ---RSSGNSSAVLGLCKKGPECANKLQYFLIMSVIGSFIYSITAIPGYMVLLRCIKPEEKSLGIG 549

  Fly   638 LALMMISLLALIPGPIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLL---TFM 698
            |......:.|.||.||.||.|||.|||.| |..|...|.|::|:...||.....|...|   :::
  Rat   550 LHAFCTRVFAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYNINNFRRIYLVLPAALRGSSYL 614

  Fly   699 GLLFDYLVWYYGRNLDIYGDKEAKEEERANRKDQPITPLLAKKSE 743
            ..||..::.   |.....|:.::.|.|.|..|      :..||||
  Rat   615 PALFILILM---RKFQFPGEIDSSETELAEMK------ITVKKSE 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	172/691 (25%)
		MFS	40..>280	CDD:119392	67/248 (27%)
		DUF4064	364..447	CDD:290013	23/103 (22%)
		KAZAL_SLC21	470..521	CDD:238650	18/52 (35%)
Slco1a5	NP_110465.1	oat	1..625	CDD:273279	179/727 (25%)
		MFS	21..>397	CDD:119392	107/424 (25%)
		KAZAL_SLC21	436..487	CDD:238650	18/51 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920