Protein Alignment Oatp33Ea and Slco1a3

DIOPT Version :9

• Sequence 1: NP_001260417.1
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_110464.2
• Gene: Slco1a3 / 80899
• RGDID: 621387
• Length: 670
• Species: Rattus norvegicus
• Alignment Length: 746
• Identity: 181/746 - (24%)
• Similarity: 296/746 - (39%)
• Gaps: 143/746 - (19%)

  Fly    31 YATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIG 95
            :|..|:|:.........:::|..:....||.:|::|.||:...|.|....||..::|.:.:||.|
  Rat    16 FAKIKVFLMALTCAYVSKSLSGTFMSSMLTQIERQFGIPTAIVGFINGSFEIGNLLLIIFVSYFG 80

  Fly    96 GQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVK 160
            .:.:||..|..|....||.|:|:.||||:.|        ..||:.::|..:..|.:||
  Rat    81 MKLHRPIVIGVGCAVMGLGCFIISLPHFLMG--------RYEYETTILPTSNLSSNSF------- 130

  Fly   161 TERLCGVDKTED--------DCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNT 217
               ||..::|:.        :|......:..:.:.:...:.|:|.|....||.:|:::..|..|:
  Rat   131 ---LCMENQTQTLNPAQDPAECVKEVKSLMWIYVLVGNIIRGIGETPIMPLGVSYIENFAKSENS 192

  Fly   218 PLMLAVAMALRMIGPVVGFFFGFISLNTFIDP----TKTPLIDSKDPRWLGAWWLGWVILGTLMC 278
            ||.:.:....:||||:.|...|....:.::|.    |....|...|.||:||||:|:::...:..
  Rat   193 PLYIGILETGKMIGPIFGLLLGSFCASIYVDTGSVNTDDLTITPTDIRWVGAWWIGFLVCAGVNI 257

  Fly   279 LFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANA 343
            |.|.....|||.|||............|..:...|..:||...::
  Rat   258 LISIPFFFFPKTLPKEGLQENVDGTENAKEEKHREKAKEEKRGIT-------------------- 302

  Fly   344 DLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPIS 408
                 |||...|..|..|.:.:...|.:|..:...:.:.:||.||:|.|:.|.......::|..:
  Rat   303 -----KDFFPFLKSLSCNPIYMLFTLISVLQVNAFNIYFSFLPKYLENQYGKSTAEVIFLMGVYN 362

  Fly   409 IMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYC--------------PNT 459
            :..:.:|.:.:|.::.|.|.:| |...:......:|     .|:|.:|              .|:
  Rat   363 LPAICIGYLIAGFMMKKFKITV-KTAAFLAFCLSLS-----EYSFGFCNFLITCDNVPVAGLTNS 421

  Fly   460 FSMTQAG---QLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGY--NATSKLYEDCS 519
            :...|..   :.|:.::||..|||...::.|||.: ....:.|||.|||...  ..|:.::.:||
  Rat   422 YERDQKPLYLENNVLADCNTRCSCLTKTWDPVCGD-NGLAYMSACLAGCEKSVGTGTNMVFHNCS 485

  Fly   520 CVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSV 584
            | :..|...||   :|.|....||
  Rat   486 C-IQSPGNSSA---VLGLCNKGPE----------------------------------------- 505

  Fly   585 IRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALI 649
                 ||....:    ..|.|..:|...|...:...:|..|.:..|:||...|:....|.:.|.|
  Rat   506 -----CTNKLQY----LLILSGFLSILYSFAAIPGYMVFLRCIKSEEKSLGIGIHAFCIRVFAGI 561

  Fly   650 PGPIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYGRNL 713
            |.||.||.|||.|||.| |:.|...|.|::||...||.....:|..|.....|..:::....|..
  Rat   562 PAPIYFGALIDRTCLHWGTQKCGAPGACRMYDINSFRRIYLGMSAALRGSSYLPAFVIVILTRKF 626

  Fly   714 DIYGDKEAKEEERANRKDQPITPLLAKKSEQ 744
            .:.|...:.|.|.|..|       |.:|..|
  Rat   627 SLPGKINSSEMEIAEMK-------LTEKESQ 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	165/679 (24%)
		MFS	40..>280	CDD:119392	65/251 (26%)
		DUF4064	364..447	CDD:290013	17/82 (21%)
		KAZAL_SLC21	470..521	CDD:238650	17/52 (33%)
Slco1a3	NP_110464.2	oat	1..625	CDD:273279	172/712 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820