DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and slco2b1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001032767.2	Gene:	slco2b1 / 792084	ZFINID:	ZDB-GENE-051023-6	Length:	677	Species:	Danio rerio

Alignment Length:	722	Identity:	185/722 - (25%)
Similarity:	316/722 - (43%)	Gaps:	132/722 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99
            |.|:..:|:|...|.:...|...::||:|||:...|..:|::.:.||:...:|.:.:|:.|.:.:
Zfish    26 KFFVLCHGMLQLSQLLVSGYLKASITTIEKRYGFSSSKSGLLAAFNEVGNTVLIVFVSFFGSRVH 90

  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVKTERL 164
            |||.|..|.:...:..:::.|||||    .|..::|:...::.||.:....   |:|.|..|
Zfish    91 RPRCIGIGGMIASMGVFLIALPHFI----SEKYEYTEFISNTRLNSSLCQT---QDIESSPT--- 145

  Fly   165 CGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAMALRM 229
            |    :::|.|......|::|  |.|.:||:|.......|.:|:||..::.|:|..|.:..|:.:
Zfish   146 C----SQNDTDPQLGVYPILL--LGQLLLGIGGVPIQPFGISYIDDYAERRNSPFYLGILFAVTV 204

  Fly   230 IGPVVGFFFGFISLNTFIDPTKTPLIDSK----DPRWLGAWWLGWVILGTLMCLFSGLIGLFPKQ 290
            |||..|:......|..::|..|..|.::|    ||||:||||||::|..||:.|.|.....||::
Zfish   205 IGPAFGYIMSSAVLRLYVDIDKMSLNENKLEHGDPRWIGAWWLGFLIAATLLSLTSLPYLFFPRK 269

  Fly   291 LPK--VNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPKLKDFPR 353
            :.|  :..:.........::..|.|..:.|.:|| ::|                     ||.||.
Zfish   270 MSKEEIEEAPVEPSTEKMIQNKKPETDQIEEVSL-TQF---------------------LKSFPT 312

  Fly   354 ALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVVGLIG 418
            .::|.|||.:.:..:.:.|......:|..||:.|::|.||.:.|..:.|::|.|:|...:.|::.
Zfish   313 IVLRTLRNPIYLLVVFAQVNLAAMVAGLATFMGKFIEKQFARTASFSNIMMGGINIPSAMFGIMA 377

  Fly   419 SGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNTFSMTQAGQLNL--TSNCNMNCSCE 481
            .|::|.:...:|........|...|||:..|...|:.||.    .:...||.  :..|:.:|.|.
Zfish   378 GGVILRRLGLTVRSSAAMCTIAVFISIMFAIPLLFIGCPT----QKISGLNYRDSQQCSNSCYCS 438

  Fly   482 GISYTPVCHEPTDTTFFSACHAGCRGYN------ATSKLYEDCSCVVNDPAPKSAAQRLLNLLQP 540
            ..::.|||.. ....|.|.|||||:..|      ..:..|.||.||.:..:|..|.
Zfish   439 DEAFNPVCGS-DGVEFRSPCHAGCKIVNIKTIGRIQNVTYTDCGCVKSSGSPGFAF--------- 493

  Fly   541 TPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGICTKNCNWSFWAFSITS 605
                                                          .|.|...|:.....|.|.|
Zfish   494 ----------------------------------------------AGPCASGCSNLLIPFMILS 512

  Fly   606 MIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFGRLIDSTCLVWTKTC 670
            .:..:..|.....:.::..|.|..||||||.|:..|:..:||.:|.|:::|..||:.||||.|.|
Zfish   513 SLTCFVASLSHTTSFMMILRTVTPEDKSFAVGIQFMLFRVLAFLPSPVLYGTAIDTACLVWGKKC 577

  Fly   671 NGNGNCQLYDQTRFRYSL----------NFLSCLLTFMGLLFDYLVWYYGRNLDIYGDKEAKEEE 725
            :.:.:|..|:...||:..          .|:..||:|:.|          |..|....::.::::
Zfish   578 SKSTSCLYYNLDLFRHRFLGLQIFFICGGFVCFLLSFLVL----------RRADSSQQQQHQQQQ 632

  Fly   726 RANRKDQ 732
            :..::.|
Zfish   633 QQQQQQQ 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	174/661 (26%)
		MFS	40..>280	CDD:119392	74/243 (30%)
		DUF4064	364..447	CDD:290013	21/82 (26%)
		KAZAL_SLC21	470..521	CDD:238650	17/58 (29%)
slco2b1	NP_001032767.2	OATP	27..591	CDD:308646	174/661 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850