Protein Alignment Oatp33Ea and Slco6c1

DIOPT Version :9

• Sequence 1: NP_001260417.1
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_083218.1
• Gene: Slco6c1 / 74441
• MGIID: 1921691
• Length: 706
• Species: Mus musculus
• Alignment Length: 746
• Identity: 151/746 - (20%)
• Similarity: 285/746 - (38%)
• Gaps: 174/746 - (23%)

  Fly    26 PWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLI 90
            |::|::.....||.:|.....|....:....:||...:.:|.:......::...:.|:..::::|
Mouse    85 PFVQRFNNIDGFMTLYVAAVLIHGALFAVVDMTLNIYQVQFSLTRTEWYLMDFSDYIASFVVAII 149

  Fly    91 LSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIYG---AGHEVLQFTKEYQDSLLNGTTGSDHS 152
            :::.|.:.||.||||...:..||...:...|.|.|.   .|.:.::...|            ::.
Mouse   150 IAHFGSKGNRTRWIAASCILMGLESMLFAFPFFTYEIIIPGRQSIELCME------------ENE 202

  Fly   153 FQNISSVKTERLCGVDKTEDDCDDLFSYVP-----LVLIFLSQFVLGVGNTLYYSLGQTYLDDNT 212
            .:||       :||            :.||     :......|.:.|:.....|.||.|::.|:.
Mouse   203 KRNI-------ICG------------NSVPNRSKCIYFHIAGQCIHGIAGMPIYILGITFIFDHI 248

  Fly   213 KKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKTPLIDSKDPR----WLGAWWLGWVIL 273
            ..::....||:..:..:||.::|...|   |..|..|.|...::.:..:    ....||..::|:
Mouse   249 PTSSCGFYLAIGHSAYLIGYLLGMVGG---LQNFQPPPKEKTVEIEPAKVYQLLQSGWWKTFLII 310

  Fly   274 GTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAA 338
            ..:....|.::..||..||..:..|      ||        ||:|..::..|..
Mouse   311 AAISFCVSFMMVCFPTSLPGAHKLR------LA--------KRKEPPTIDRRLK----------- 350

  Fly   339 AGANADL---PKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSA 400
                 |:   |.||.|...:..:|:|.|::...:..|...|..:..:.||..:::.||......|
Mouse   351 -----DMKIQPHLKGFLHNIWHILKNPLMLTQAICKVSEYLTFNTSLYFLPHHLQTQFLITPGIA 410

  Fly   401 TIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNTFSMTQA 465
            :::.|...:.|.::|....|:::.:.:.:....|.:.::...:|:...:...|:.|..|   |.|
Mouse   411 SLLTGAFVLPGGIIGHFLGGLIVDRLEMTNKNKLKFTLVTTVVSVGLFLLIFFVECQTT---TFA 472

  Fly   466 ---------GQL-NLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRG--YNATSKLYEDC 518
                     ||| |||::||..|.|....||.:|.. .:..:||.|.|||:.  .:.|.|.|.:|
Mouse   473 GINEDYDGYGQLGNLTADCNEYCDCTTSLYTSICGR-DEKEYFSPCFAGCKATKVSQTEKTYYNC 536

  Fly   519 SCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDS 583
            ||:                                  ..|:...||.|.|.|.:
Mouse   537 SCI----------------------------------KEGLAASDDEGQFIDAI----------- 556

  Fly   584 VIRPGICTKNCNW--SFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLL 646
               .|.|..:|..  .|:||..::.:   |.:...:..:.:..::|.....|.:.|:...::..:
Mouse   557 ---AGTCDSDCLKLPLFFAFYFSATV---FSNMCSIPVISIILQSVPANFTSLSLGVTYAIVKFV 615

  Fly   647 ALIPGPIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGL-----LFDYL 705
            |.:|.|::|.......|:.| ...|.|...|.:|::....|.         |||:     |...|
Mouse   616 ASVPAPLLFRLSSAIACIYWDNNRCGGKERCWIYNKNILVYE---------FMGIWMSSQLIIVL 671

  Fly   706 VWYYG---RNLDIYGD--------KEAKEEE 725
            :..|.   .::.::|:        |:.||::
Mouse   672 LNIYAIQIHDVVVHGEITESKTTVKDVKEQK 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	138/677 (20%)
		MFS	40..>280	CDD:119392	47/251 (19%)
		DUF4064	364..447	CDD:290013	13/82 (16%)
		KAZAL_SLC21	470..521	CDD:238650	20/52 (38%)
Slco6c1	NP_083218.1	OATP	95..654	CDD:281175	138/677 (20%)
		MFS	97..>463	CDD:119392	81/429 (19%)
		KAZAL_SLC21	487..540	CDD:238650	21/87 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810