DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Ea and Gm6614

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001074787.1	Gene:	Gm6614 / 625716	MGIID:	3647159	Length:	650	Species:	Mus musculus

Alignment Length:	713	Identity:	169/713 - (23%)
Similarity:	280/713 - (39%)	Gaps:	132/713 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 QAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRNRPRWIAWGIVFCG 112
            :::|..|.:..||.:|::|.||:...|:|.....|..::|.:.::|.|.|.:||..|..|....|
Mouse    13 KSLSGTYMVSMLTQIERQFDIPASIAGLISGSFGIGNLLLIVFVNYFGMQLHRPIIIGVGCATMG 77

  Fly   113 LSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVKTERLCGVDKTED--DCD 175
            |.|:::.||||:.|        ..||:..:...:....:||..:.:    |...:..|:|  :|.
Mouse    78 LGCFLISLPHFLMG--------IYEYETMISPASNLPSNSFLCVEN----RSQTLKPTQDPAECV 130

  Fly   176 DLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAMALRMIGPVVGFFFGF 240
            ........:.:.:...:.|:|.|....||.:|::|..|..|:||.:.:....:|.|||:|...|.
Mouse   131 KEIKSSMWIYVLVGNIIRGIGETPLLPLGVSYIEDFAKSENSPLYIGILETGKMFGPVIGLLLGS 195

  Fly   241 ISLNTFIDP----TKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSGLIGLFPKQLPKVNASRTNS 301
            ...:.::|.    |....|...|.||:||||:|:::...:..|.|.....|||.||:........
Mouse   196 FCASIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNVLTSIPFFFFPKTLPEEGLQDNGD 260

  Fly   302 HLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPKLKDFPRALMRLLRNKLLIF 366
            .......:...|..:|||..::                         |||...:..|..:.:.:.
Mouse   261 GTENDKEEKHREKAKEENRGIT-------------------------KDFFPFMKSLSCDPIYVL 300

  Fly   367 NILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVVGLIGSGMVLSKKKPSVS 431
            .||.:|..|...:....||:||:|.||.|........:|..::..:.:|.:.:|.::.|.|.:|.
Mouse   301 FILISVLQISTFTSTFNFLSKYLEQQFGKSTAEVVFFIGLYTLPTICIGYLIAGFIMKKFKITVK 365

  Fly   432 K---------------------VLMWNVIVGGISILGQISYAFLYCPNTFSMTQAGQLNLTSNCN 475
            |                     :...||.|.|::|..:.....||..|          |:.::||
Mouse   366 KAAYLAFCLSLCEYLFGFCNFLIACDNVPVSGLTISYEGVQHPLYVEN----------NVLADCN 420

  Fly   476 MNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNAT--SKLYEDCSCVVNDPAPKSAAQRLLNLL 538
            ..|||...::.|||.: ...:|.||||.||.....|  :.::::|||:.:...|.:    :|.|.
Mouse   421 TRCSCLTKTWDPVCGD-NGLSFMSACHTGCEKSVGTGINMVFQNCSCIGSSGKPSA----VLGLR 480

  Fly   539 QPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGICTKNCNWSFWAFSI 603
            :..||                                                  |........|
Mouse   481 EKGPE--------------------------------------------------CANKLQHLLI 495

  Fly   604 TSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFGRLIDSTCLVW-T 667
            .|:.:|...|........|..|.|..|:||...|:......:...||.|:..|.|:|.|||.| |
Mouse   496 LSVFLSVIYSLSATPGYTVLLRCVESEEKSPGVGIHTFCTRVFGGIPAPVYIGALLDRTCLHWGT 560

  Fly   668 KTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYGRNLDIYGDKEAKEEERANRK 730
            :.|...|.|::||...||.....|...|..:..|..:::....|...:.|:..:.|.|.|..|
Mouse   561 QKCGEPGACRMYDINSFRSIYLGLPAALRGISYLPAFIIVILIRKFCLPGEINSSEMEIAEMK 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	158/665 (24%)
		MFS	40..>280	CDD:119392	63/237 (27%)
		DUF4064	364..447	CDD:290013	24/103 (23%)
		KAZAL_SLC21	470..521	CDD:238650	18/52 (35%)
Gm6614	NP_001074787.1	oat	1..605	CDD:273279	163/693 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D434101at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920