Protein Alignment Oatp33Ea and slco1b3

DIOPT Version :10

• Sequence 1: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: XP_031753845.1
• Gene: slco1b3 / 613085
• XenbaseID: XB-GENE-5943217
• Length: 690
• Species: Xenopus tropicalis
• Alignment Length: 731
• Identity: 195/731 - (26%)
• Similarity: 302/731 - (41%)
• Gaps: 155/731 - (21%)

  Fly     8 DPNRPPGHYLCGMANW---HPPWLQKY---ATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRF 66
            :||..|...|  |:|.   .||  ||.   :..|||:.........:|.|..|...::|.:|:||
 Frog    12 NPNMDPPEVL--MSNGGGETPP--QKVSCCSNLKMFLVALCFSYFAKAFSGSYMKSSITQIERRF 72

  Fly    67 KIPSQTTGIILSGNEISQIMLSLILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEV 131
            .|.|.|.|:|....||..:|:..|:||.|.|.:|||.||.|.:...|..::..:|||..|.
 Frog    73 DISSSTVGMIDGSFEIGNLMVIAIVSYFGAQFHRPRIIAAGCILMSLGSFLTAMPHFFMGL---- 133

  Fly   132 LQFTKEYQDSLLNGTTG-SDHSFQNISSVKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGV 195
                  |:...:.|.|. :.::..|:|.....|.. ||..:.||.........|.:.:...:.|:
 Frog   134 ------YKYETVGGPTSLNSNATINVSPCLANRSL-VDTPKPDCVTENGSHMWVFLLVGNILRGI 191

  Fly   196 GNTLYYSLGQTYLDDNTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFID----PTKTPLID 256
            |.|....||.:||||.::..||||.:|....:.|.||:.||..|......::|    .|.|..|.
 Frog   192 GETPIAPLGISYLDDFSRPENTPLHIACLHTVAMFGPMTGFMLGSFLARLYVDIGFVDTDTITIT 256

  Fly   257 SKDPRWLGAWWLGWVILGTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLS 321
            .:|.||:||||:|:::.|.:. |.|.:...|               ||.:|::.:.|.::.:...
 Frog   257 PQDTRWVGAWWIGFLLSGAVN-LMSAIPFFF---------------LPESLKEEQREGQKPQTKQ 305

  Fly   322 LSSRFSSNAALDTIGAAAG-ANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFL 385
                          |...| ...:.|.|:.|..||..|..|:|.:..:...:.......||:|:.
 Frog   306 --------------GEEKGHKQKEKPTLRGFFAALKTLCFNRLFVMLMCLTLLQTNSFLGFITYK 356

  Fly   386 TKYMEVQFHKDAQSATIIVG----PISIMGMVVGLIGSGMVLSKKK---PSVSKVLMWNVIVGGI 443
            .||||.|:.:....|..:.|    |.:.:||.:|    |:::.:.|   ...||:..      |.
 Frog   357 PKYMEQQYGQSISKANFVTGVSTLPAAALGMFLG----GLIMKRYKFGLLGASKMAY------GT 411

  Fly   444 SILG---QISYAFLYCPN--------TFSMTQAGQLN---LTSNCNMNCSCEGISYTPVCHEPTD 494
            |:|.   .:|..|:.|.|        |:...:.....   :.|.||.:|.|....:.|||.| ..
 Frog   412 SLLAFLLSLSAFFIGCENNNVAGITVTYDRVKVNNFQDRIIYSPCNSDCHCSSKQWDPVCGE-NG 475

  Fly   495 TTFFSACHAGCRGYNAT--SKLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLS 557
            .|:.|||.|||:....:  ..:|.:|||:  |.|..:|.....:|
 Frog   476 VTYVSACLAGCKASTGSGLGTVYHNCSCI--DTALSTAVNSSAHL-------------------- 518

  Fly   558 GVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGICTK--NCNWSFWAFSITSMIVSWFGSSGRVGNV 620
                                          |.|.:  :|:..|..:.:|..|.::..:.|.....
 Frog   519 ------------------------------GSCPRGPDCSRMFMFYVVTQAINTFIFALGASSAY 553

  Fly   621 LVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRF 684
            ::...:|..|.||.|.|:.:::|..||.||.||.||.:||.:||.| |:.|.|.|.|:|||...|
 Frog   554 VLLLWSVNPEMKSLAVGVYMLLIRTLAGIPAPIYFGAIIDKSCLKWGTRLCGGRGACRLYDADSF 618

  Fly   685 RYSLNFLSCLLTFMGL 700
            |         ..|:||
 Frog   619 R---------RRFLGL 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	179/679 (26%)
slco1b3	XP_031753845.1	MFS_SLCO1B_OATP1B	40..558	CDD:341015	152/621 (24%)