Protein Alignment Oatp33Ea and Slco1c1

DIOPT Version :10

• Sequence 1: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_067446.1
• Gene: Slco1c1 / 58807
• MGIID: 1889679
• Length: 715
• Species: Mus musculus
• Alignment Length: 752
• Identity: 197/752 - (26%)
• Similarity: 324/752 - (43%)
• Gaps: 139/752 - (18%)

  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99
            |:|:|....:...:|::..|...|:|.:|:||:|||...|||....||..:::...:||.|.:.:
Mouse    43 KVFLGALSFVYFAKALAEGYLKSTVTQIERRFEIPSSLVGIIDGSFEIGNLLVITFVSYFGAKLH 107

  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTK--EYQDSLLNGTTGSDHSFQNISSVKTE 162
            ||:.|..|.:..|....::.:|.|..    |...:.|  .|..| .|.|......:...||....
Mouse   108 RPKIIGAGCLVMGFGTMLIAVPQFFM----EKYSYEKYERYSPS-SNVTPSISPCYLESSSPSPS 167

  Fly   163 RLCG--VDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAM 225
            .:.|  .:|...:|....|....|.:||...:.|:|.|....||..||||...:.|....:....
Mouse   168 SILGKSQNKISHECVGDSSSSMWVYVFLGNLLRGLGETPIQPLGIAYLDDFASEDNAAFYIGCVQ 232

  Fly   226 ALRMIGPVVGFFFGFISLNTFID--------PTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSG 282
            .:.:|||:.||..|.:....::|        .|.||    |||:|:||||||::|.|.|..|.:.
Mouse   233 TVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITP----KDPQWVGAWWLGYLIAGFLSLLAAV 293

  Fly   283 LIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPK 347
            .....||.||: :.||.||      ..|.|:          |:|..    |.|........|..|
Mouse   294 PFWCLPKTLPR-SQSRENS------GSTSEK----------SKFID----DPIHYQMAPGDDKMK 337

  Fly   348 L----KDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPIS 408
            :    |||..:|..|.||.:.|..:.::........|.:|:..||:|.|:.:.:..|..::|.|:
Mouse   338 IMEMAKDFLPSLKTLFRNPVYILYLCASTVQFNSLFGMVTYKPKYIEQQYGQSSSKANFVIGLIN 402

  Fly   409 IMGMVVGLIGSGMVLSKKKPSV---SKVLMWNVIVGGISILGQISYAFLY---CPNT----FSMT 463
            |..:.:|:...|:|:.|.:..:   :|:.:      |.|:.|.:.:..|:   |.|:    .:::
Mouse   403 IPAVALGIFSGGIVMKKFRLGICEATKLYL------GSSVFGYLLFLSLFALGCENSSVAGLTVS 461

  Fly   464 QAG-------QLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSK--LYEDCS 519
            ..|       :..|.|:||..|.|....:.|:|.: ...|:.|||.|||:..:.:.|  ::.:|:
Mouse   462 YQGTKPVSYHERALFSDCNSRCKCSDSKWEPMCGD-NGITYVSACLAGCQSSSRSGKNIIFSNCT 525

  Fly   520 CVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSV 584
            | |...||||                                    |::...:
Mouse   526 C-VGFAAPKS------------------------------------GNWSGMM------------ 541

  Fly   585 IRPGICTKN--CNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLA 647
               |.|.|:  |:..|..|.:.|:|.|:..|.|.:...::..|.:..:.||||.|:..:.:.:||
Mouse   542 ---GRCQKDNGCSQMFLYFLVISVITSYTLSLGGIPGYILLLRCIQPQLKSFALGIYTLAVRVLA 603

  Fly   648 LIPGPIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLL------TFMGLLFDYL 705
            .||.|:.||.|||::||.| .|.|...|:|:|||...||:....|:.||      ..|.:||...
Mouse   604 GIPAPVYFGVLIDTSCLKWGFKKCGSRGSCRLYDSHAFRHIYLGLTTLLGTVSVFLSMAVLFVLK 668

  Fly   706 VWYYGRNLDIYGDKE------AKEEERANRKDQPITP 736
            ..|..::..:...:|      :.::|....:|:.:.|
Mouse   669 KKYVSKHSSLITTREKIGMSSSIKKETCAARDRGLQP 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	183/685 (27%)
Slco1c1	NP_067446.1	MFS	42..582	CDD:475125	158/627 (25%)