DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and slco3a1a

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001038653.1	Gene:	slco3a1a / 569735	ZFINID:	ZDB-GENE-030131-8662	Length:	701	Species:	Danio rerio

Alignment Length:	719	Identity:	194/719 - (26%)
Similarity:	306/719 - (42%)	Gaps:	121/719 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIG 95
            ::..|:|:.....|...|.....|.:..|||||:||.:.|...|:|.|..||..:.|.|.:||.|
Zfish    24 FSNIKIFLVAECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFG 88

  Fly    96 GQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVK 160
            .:.:|||.|..|.:...|...:..||.|:          ..:|:   :..|...|.. :::.|
Zfish    89 AKAHRPRLIGCGGIVMALGALLSALPEFL----------ASQYK---ITDTWSKDQG-RDVCS-- 137

  Fly   161 TERLCGVDKTEDDCDDLFSYVPLVLIFL-SQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVA 224
                 ...|.::.|.:..:...:.|:.: :|.:||:|.|....||.:|:||:.:|.::.|.:.:.
Zfish   138 -----NTSKADEPCGNRANTNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRKKDSSLYIGIL 197

  Fly   225 MALRMIGPVVGFFFGFISLN-----TFIDPTK---TPLIDSKDPRWLGAWWLGWVILGTLMCLFS 281
            .:..:.||..||..|.:..|     .|||.|:   ||    .||||:||||.|::|.|.|: .||
Zfish   198 FSTLVFGPACGFILGSVCTNFYVDALFIDTTQLNITP----DDPRWIGAWWGGFLICGALL-FFS 257

  Fly   282 GLIGL-FPKQLPKVN----ASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGA 341
            .|... ||:.||...    .....:.||.:|.|..|:.|           .||..:......:.:
Zfish   258 ALFMFGFPQSLPSKEMEGVPESEQAMLPASLSQDFEKSK-----------PSNGVVQNYQPNSNS 311

  Fly   342 NADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGP 406
            .:...:|:..|:....||.|.:....:|:|...|...:||..||.||:|.||:....||..::|.
Zfish   312 LSCCQQLRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGM 376

  Fly   407 ISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPN--TFSMT------ 463
            .:|....:|:...|:::.|...|....:...::|..||....:|:.||.|..  ...:|
Zfish   377 TAIPCACLGIFLGGLLVKKLNLSALGAIRMAMLVNLISTACYVSFLFLGCDTGPVAGVTVAYGNE 441

  Fly   464 --QAGQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSKLYEDCSCVVNDPA 526
              |.|| ...:.|..:|:|...|.:|||.. ...|:.|:|.|||....:|..           ||
Zfish   442 TLQVGQ-TPEAPCMSHCNCYTSSVSPVCGS-NGVTYLSSCFAGCTRAISTGL-----------PA 493

  Fly   527 PKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGICT 591
            |.|                        :.|||...:....||              :...||.|.
Zfish   494 PLS------------------------QNLSGCACISGYNDF--------------ATAVPGKCP 520

  Fly   592 K-NCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIF 655
            : .|..:|..|.......|..|:..:..:|::..|.|:.|.||:|.|:..:::.||..||.|:||
Zfish   521 RPGCQEAFLTFLCVICGCSMIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIF 585

  Fly   656 GRLIDSTCLVWTKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWY--------YGRN 712
            |..||||||.|:..|...|.|.|||...:|:....::.:|..|..|.....|:        |.:|
Zfish   586 GAGIDSTCLFWSAECGVKGACLLYDNVTYRHLYISMAIVLKIMAFLLYTTTWHCLRRNYKKYIKN 650

  Fly   713 LDIY 716
            ::.|
Zfish   651 IEGY 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	185/672 (28%)
		MFS	40..>280	CDD:119392	73/248 (29%)
		DUF4064	364..447	CDD:290013	23/82 (28%)
		KAZAL_SLC21	470..521	CDD:238650	14/50 (28%)
slco3a1a	NP_001038653.1	OATP	29..614	CDD:281175	185/672 (28%)
		MFS	35..>265	CDD:119392	76/255 (30%)
		KAZAL_SLC21	449..506	CDD:238650	21/92 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578756
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750