Protein Alignment Oatp33Ea and slco4a1

DIOPT Version :9

• Sequence 1: NP_001260417.1
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_001297061.1
• Gene: slco4a1 / 567865
• ZFINID: ZDB-GENE-060606-4
• Length: 742
• Species: Danio rerio
• Alignment Length: 733
• Identity: 178/733 - (24%)
• Similarity: 293/733 - (39%)
• Gaps: 157/733 - (21%)

  Fly    17 LCGMANWHPPWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVT-LTTLEKRFKIPSQTTGIILSGN 80
            |||.....|..:|.:.|.:..:....:...:|.|....||.| :|::|:|..:.|...|:|.|..
Zfish    80 LCGWGALTPRCIQTFNTPRWVLFFLCVASFLQGMIINGFINTVITSIERRLDLRSYQAGLIASSY 144

  Fly    81 EISQIMLSLILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLN- 144
            :|:..:....:||.||..::|||:.||::...|...:..||||.          |..||..:..
Zfish   145 DIAACLCLTFVSYFGGTGHKPRWLGWGVLVMALGSLVFALPHFT----------TPAYQVRVPER 199

  Fly   145 -GTTGSDHSFQNISSVKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYL 208
             |....:|         ||...|    |:.....:.||    ..|.|.:.|||.|..|:||.|||
Zfish   200 MGLCSENH---------TETCVG----EEGGLSAYRYV----FMLGQSLHGVGATPLYTLGVTYL 247

  Fly   209 DDNTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKTPLIDSKDPRWLGAWWLGWVIL 273
            |:|.|....|:.:.:.....::||..|:..|...||.:.:..:|..:..::|.|:||||:|::..
Zfish   248 DENVKSNYAPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIGQTTELTPENPLWVGAWWIGFLAG 312

  Fly   274 GTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTK-EELKREENLSLSS-RFSSNAALDTIG 336
            |....|.:..|..:|:|||       .|...:|:|.:: .:||....::.|. :|...
Zfish   313 GAAALLIALPILGYPRQLP-------GSQRYVAMRVSEAHQLKDGSQVTASDPQFGKT------- 363

  Fly   337 AAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSAT 401
                       :||.||:::.||:|...||..|:........:|..||..|::|.||...|..|.
Zfish   364 -----------VKDMPRSMLLLLKNPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSASEAA 417

  Fly   402 IIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNT--FSMTQ 464
            ...|.:.:.....|....|.::.|.......::.:.::...:|::. |....::|||.  ..:|.
Zfish   418 TWFGYMVVPAGGGGTFLGGFIIKKLNLRCRGIIRFCMLCALVSLMA-IFIFLVHCPNVPMAGVTI 481

  Fly   465 AGQLNLTSN-------------------------CNMNCSCEGISYTPVCHEPTDTTFFSACHAG 504
            :...|:|.|                         ||:.|.|...|:.||| ......:||.||||
Zfish   482 SYYSNVTHNHNSALYLQKDKHNSSFSDLSNPTVACNIGCHCLEESFNPVC-GADGVMYFSPCHAG 545

  Fly   505 CRGYNAT-----SKLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDD 564
            |...|.|     .:::..||||..
Zfish   546 CSSLNHTFGPRGRQVFSGCSCVAG----------------------------------------- 569

  Fly   565 NGDFDDQLLSRTRRSTSDSVIRPGICTKNCNW--SFWAFSITSMIVSWFGSSGRVGNVLVNYRAV 627
            |..:.:|           .....|.|..:||.  :|..|....::.::..|   :..:....|.|
Zfish   570 NISWGEQ-----------GFAEEGRCVSSCNHMPAFLTFLFILILFTFLCS---IPALTATLRCV 620

  Fly   628 AHEDKSFAQGLALMMISLLALIPGPIIFGRLIDSTCLVWTKTCNGNGNCQLYDQTRF-RYSLNFL 691
            ....:||..|:..:::..|..|||||.||.:||.:||:|.:.|...|:|.||..:.. :|||
Zfish   621 PDSQRSFGLGIQWIVVRTLGGIPGPIAFGSVIDISCLLWEEQCGEYGSCYLYHNSAMSQYSL--- 682

  Fly   692 SCLLTFMGLLFDYLVWYY 709
                 ..|:::..|..::
Zfish   683 -----VAGIIYKVLGTFF 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	167/686 (24%)
		MFS	40..>280	CDD:119392	69/242 (29%)
		DUF4064	364..447	CDD:290013	17/82 (21%)
		KAZAL_SLC21	470..521	CDD:238650	21/80 (26%)
slco4a1	NP_001297061.1	OATP	99..677	CDD:281175	167/686 (24%)
		MFS	101..>285	CDD:119392	60/210 (29%)
		KAZAL_SLC21	512..567	CDD:238650	19/55 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810