Protein Alignment Oatp33Ea and SLCO1C1

DIOPT Version :9

• Sequence 1: NP_001260417.1
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_001139418.1
• Gene: SLCO1C1 / 53919
• HGNCID: 13819
• Length: 730
• Species: Homo sapiens
• Alignment Length: 703
• Identity: 181/703 - (25%)
• Similarity: 301/703 - (42%)
• Gaps: 152/703 - (21%)

  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99
            |:|:.....:...:|::..|...|:|.:|:||.|||...|:|....||..:::...:||.|.:.:
Human    43 KVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLH 107

  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQ---------------DSLLNGTTGS 149
            ||:.|..|.|..|:...::.:|.|          |.::|:               ..||..::..
Human   108 RPKIIGAGCVIMGVGTLLIAMPQF----------FMEQYKYERYSPSSNSTLSISPCLLESSSQL 162

  Fly   150 DHSFQNISSVKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKK 214
            ..|....|..|....|.||.:    ..::.||     ||...:.|:|.|....||..||||...:
Human   163 PVSVMEKSKSKISNECEVDTS----SSMWIYV-----FLGNLLRGIGETPIQPLGIAYLDDFASE 218

  Fly   215 TNTPLMLAVAMALRMIGPVVGFFFGFISLNTFID--------PTKTPLIDSKDPRWLGAWWLGWV 271
            .|....:.....:.:|||:.||..|.:....::|        .|.||    |||:|:||||||::
Human   219 DNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITP----KDPQWVGAWWLGYL 279

  Fly   272 ILGTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALD--- 333
            |.|.:..|.:......||.||:              .|::|:       |.||...|...:|
Human   280 IAGIISLLAAVPFWYLPKSLPR--------------SQSRED-------SNSSSEKSKFIIDDHT 323

  Fly   334 TIGAAAGANADLPKL-KDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDA 397
            ......|.||.:.:: :||..:|..|..|.:....:.::........|.:|:..||:|.|:.:.:
Human   324 DYQTPQGENAKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSS 388

  Fly   398 QSATIIVGPISIMGMVVGLIGSGMVLSKKKPSV---SKVLMWNVIVGGISILGQISYAFLY---C 456
            ..|..::|.|:|..:.:|:...|:|:.|.:.||   :|:.:      |.|:.|.:.:..|:   |
Human   389 SRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYL------GSSVFGYLLFLSLFALGC 447

  Fly   457 PNT----FSMTQAG-------QLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNA 510
            .|:    .:::..|       :..|.|:||..|.|....:.|:|.| ...|:.|||.|||:..|.
Human   448 ENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGE-NGITYVSACLAGCQTSNR 511

  Fly   511 TSK--LYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLL 573
            :.|  ::.:|:||                                    |:
Human   512 SGKNIIFYNCTCV------------------------------------GI-------------- 526

  Fly   574 SRTRRSTSDSVIRPGICTKN--CNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQ 636
            :.::...|..::  |.|.|:  |...|..|.:.|:|.|:..|.|.:...::..|.:..:.||||.
Human   527 AASKSGNSSGIV--GRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFAL 589

  Fly   637 GLALMMISLLALIPGPIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSL 688
            |:..:.|.:||.||.|:.||.|||::||.| .|.|...|:|:|||...|||.:
Human   590 GIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRYQI 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	177/696 (25%)
		MFS	40..>280	CDD:119392	71/262 (27%)
		DUF4064	364..447	CDD:290013	19/85 (22%)
		KAZAL_SLC21	470..521	CDD:238650	19/52 (37%)
SLCO1C1	NP_001139418.1	MFS_SLCO1C_OATP1C	42..579	CDD:341017	151/638 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820