Protein Alignment Oatp33Ea and Slco1a1

DIOPT Version :10

• Sequence 1: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_058807.1
• Gene: Slco1a1 / 50572
• RGDID: 3700
• Length: 670
• Species: Rattus norvegicus
• Alignment Length: 745
• Identity: 188/745 - (25%)
• Similarity: 298/745 - (40%)
• Gaps: 163/745 - (21%)

  Fly    34 TKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQR 98
            ||...|||        |:.|     ||.:|::|.|.:...|:|....||..:...:.:||.|.:.
  Rat    32 TKSLSGVY--------MNSM-----LTQIERQFDISTSVAGLINGSFEIGNLFFIVFVSYFGTKL 83

  Fly    99 NRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVKTER 163
            :||..|..|.|..||.|.::.||||..|        ..||:.::  ..||      |:||  ...
  Rat    84 HRPVVIGIGCVIMGLGCLLMSLPHFFMG--------RYEYETTI--SPTG------NLSS--NSF 130

  Fly   164 LCGVDKTED--------DCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLM 220
            ||..::|:.        :|......:..:.:.:...:.|:|.|....||.:|::|..|..|:||.
  Rat   131 LCMENRTQTLKPTQDPAECVKEMKSLMWICVMVGNIIRGIGETPIVPLGISYIEDFAKSENSPLY 195

  Fly   221 LAVAMALRMIGPVVGFFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFS 281
            :.:....::.||:.|...|......::|    .|....|...|.||:||||:|:::...:..|.|
  Rat   196 IGILEMGKVAGPIFGLLLGSYCAQIYVDIGSVNTDDLTITPSDTRWVGAWWIGFLVCAGVNILTS 260

  Fly   282 GLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLS-----SRFSSNAALDTIGAAAGA 341
            ......||.|||..                    ::||::::     .::...|..:.:|..
  Rat   261 IPFFFLPKALPKKG--------------------QQENVAVTKDGKVEKYGGQAREENLGIT--- 302

  Fly   342 NADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGP 406
                   |||...:.||..|.:.:..||::|..:.|.....|||.||:|.|:.|....|..::|.
  Rat   303 -------KDFLTFMKRLFCNPIYMLFILTSVLQVNGFINKFTFLPKYLEQQYGKSTAEAIFLIGV 360

  Fly   407 ISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNT----FSMTQAG- 466
            .|:..:.:|.:..|.::.|.|.:|.|.......:.....|..:.:..|.|.|.    .:.:..|
  Rat   361 YSLPPICLGYLIGGFIMKKFKITVKKAAYLAFCLSVFEYLLFLCHFMLTCDNAAVAGLTTSYKGV 425

  Fly   467 --QLNLTS----NCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGY--NATSKLYEDCSCVVN 523
              ||::.|    :||..|||...::.|||.: ....:.|||.|||:.:  ..|:.:::||||:
  Rat   426 QHQLHVESKVLADCNTRCSCSTNTWDPVCGD-NGVAYMSACLAGCKKFVGTGTNMVFQDCSCI-- 487

  Fly   524 DPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPG 588
                    |.|.|                                            |.:|:  |
  Rat   488 --------QSLGN--------------------------------------------SSAVL--G 498

  Fly   589 ICTK--NCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPG 651
            :|.|  .|......|.|.::|:|:..|...:...:|..|.|..|:||...||....|.:.|.||.
  Rat   499 LCKKGPECANRLQYFLILTIIISFIYSLTAIPGYMVFLRCVKSEEKSLGVGLHTFCIRVFAGIPA 563

  Fly   652 PIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYGRNLDI 715
            |:.||.|||.|||.| |..|...|.|::||...||:....|...|.....|..:.:....|....
  Rat   564 PVYFGALIDRTCLHWGTLKCGQRGACRMYDINSFRHIYLGLPIALRGSSYLPAFFILILMRKFQF 628

  Fly   716 YGDKEA------------KEEERANRKDQP 733
            .||.::            ||.|..:....|
  Rat   629 PGDIDSSATDHTEMMLGEKESEHTDVHGSP 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	174/680 (26%)
Slco1a1	NP_058807.1	oat	1..625	CDD:273279	181/710 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..670		4/14 (29%)