DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Ea and slco1f1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_017210475.1	Gene:	slco1f1 / 405853	ZFINID:	ZDB-GENE-040426-2192	Length:	638	Species:	Danio rerio

Alignment Length:	710	Identity:	183/710 - (25%)
Similarity:	301/710 - (42%)	Gaps:	151/710 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99
            |:|:.........::|:..|...|:|.:||||:|.|.|.|.|....|:..:::..::||:|.:.:
Zfish    28 KIFICALAFCYFSKSMTASYTKSTITQIEKRFEITSSTVGFIDGSFEMGNMLVITLVSYVGAKFH 92

  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVKTERL 164
            ||:.|..|::..|:...::..|||:.|          .|:.......|....:|..||:..::..
Zfish    93 RPKIIGAGVLLMGIGTLLMASPHFLMG----------RYKYGTAATHTNDAGNFTVISTCSSDSQ 147

  Fly   165 CGVDKTEDDCD--DLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAMAL 227
            ..:.:...:|.  :..|.:..|::.|...:.|:|......||.:::||..:..|:...:.....|
Zfish   148 ETLQQPYSECQIIEAESSLLWVVVLLGNAMRGIGEASIVPLGMSFIDDYARPENSAFYIGCLNTL 212

  Fly   228 RMIGPVVGFFFGFISLNTFID--------PTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSGLI 284
            |.|||:.||..|.:..|.::|        .|.||    :|.||:||||||:|:.|.|..|.:...
Zfish   213 RGIGPIFGFILGSLCANLYVDFDLVNQESVTITP----QDSRWVGAWWLGFVVSGLLTLLAAFPF 273

  Fly   285 GLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPKLK 349
            ...|:.||:      ||       || .||...     |.:..:..:|..|            :|
Zfish   274 WFLPRALPE------NS-------QT-SELDHP-----SEQHKTTPSLTEI------------IK 307

  Fly   350 DFPRALMRLLRNKLLIFNILSAVFYILGASGF---MTFLTKYMEVQFHKDAQSATIIVGPISIMG 411
            ||.....|||.||:.   ||...:.|:..:.|   .|:..||:|.||.:.|..|..::|...|..
Zfish   308 DFAPTFKRLLTNKIY---ILYLAYSIVAFNDFAIVATYTPKYLEQQFGQSASKANFLIGVTCIPA 369

  Fly   412 MVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNTFSMTQAGQL-------- 468
            :.:|:..||:::.:.|..:......|:..|...:|..:.:..|.|.|   :..||..
Zfish   370 VALGIFLSGLMMKRFKWGLLASARVNLFTGVTMLLLAVPFFALSCEN---LDVAGVTVPYQGSTE 431

  Fly   469 ------NLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCR-----GYNATSKLYEDCSCVV 522
                  ::..:||.:|.|..:.:.|||.| ...|:.|.|||||.     |:|   |.:.||.|:.
Zfish   432 VQGVISDVLPSCNADCGCPDLQWDPVCGE-NGVTYISPCHAGCNSTQGAGWN---KTFHDCRCIQ 492

  Fly   523 NDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRP 587
            :                                 .|:.:                 ..|.:|:
Zfish   493 S---------------------------------WGLSV-----------------GNSSAVL-- 505

  Fly   588 GICTK--NCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIP 650
            |.|::  |||...:.|.....:|.:..|.|.|..:..:.|.|..|.|:.:.|:.|:.|.:|..||
Zfish   506 GQCSRDPNCNQMIYVFLGVQSLVLFVYSLGAVPFLTFSMRIVDPEMKALSVGVLLLSIRVLGGIP 570

  Fly   651 GPIIFGRLIDSTCLVW--TKTCNGNGNCQLYDQTRFRY-------SLNFLSCLLTFMGLL 701
            .||.||.|||:|||.|  .|:| |.|.|::||...||:       .|..|:|.:.::..:
Zfish   571 APIYFGGLIDTTCLKWGQRKSC-GRGACRIYDNETFRFLFQGMTIGLRVLACSVLWIATI 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	177/683 (26%)
		MFS	40..>280	CDD:119392	67/249 (27%)
		DUF4064	364..447	CDD:290013	20/85 (24%)
		KAZAL_SLC21	470..521	CDD:238650	20/55 (36%)
slco1f1	XP_017210475.1	OATP	29..605	CDD:281175	177/683 (26%)
		MFS	31..>413	CDD:119392	109/429 (25%)
		KAZAL_SLC21	440..492	CDD:238650	21/55 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920