DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and Slco6d1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_017452073.1	Gene:	Slco6d1 / 367321	RGDID:	1359388	Length:	723	Species:	Rattus norvegicus

Alignment Length:	767	Identity:	163/767 - (21%)
Similarity:	291/767 - (37%)	Gaps:	191/767 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKI------PSQTTGIIL-SGNEIS 83
            |.||::.....|:..| .|||: |...::.:|     ::..|:      ||:...:.: ||::::
  Rat    76 PCLQRFNNINCFLTAY-FLGTM-AHGMIFGLV-----DQSLKVYVSELSPSKLETLTMGSGDDLA 133

  Fly    84 QIMLSLILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTG 148
            ..::||:.::.||:.||.||:.......||:..:..:|.|.|    |:::.          ||..
  Rat   134 AFLVSLVGAHFGGRGNRVRWMVAACFVTGLASMVFAIPFFNY----EIIKL----------GTVT 184

  Fly   149 SDHSFQNISSVKTERLCGVDKT----EDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLD 209
            .:..   |...||.::|  ::|    :..|...|::        .||:.|:....:|.|..:::.
  Rat   185 DELC---IEGKKTTKVC--ERTVIPHKSTCIAFFNF--------GQFLHGIAGMPFYLLAFSFIF 236

  Fly   210 DNTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKTPLIDSKDPRWLG---------- 264
            |:....::.|.||:|.....:|.|:|:..|   :...:.|.|      :|.:.:|
  Rat   237 DHVPTCSSGLYLAIADTALSVGYVLGYLVG---IRNRMFPVK------EDMKAVGHVQQFRILQR 292

  Fly   265 AWWLGWVILGTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSN 329
            .||..:..:.......:..:..||        ||......:.|.::||.
  Rat   293 NWWRSYFAVAVFAFCTTLPLSCFP--------SRLRGAQQIRLEKSKEP---------------- 333

  Fly   330 AALDTIGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAV--FYILGASGFMTFLTKYMEVQ 392
               .||..........|.||....|:..||||.|::......|  ...|.:||:  ||.|:::..
  Rat   334 ---PTIDRRLKDKEIQPGLKGVLHAIWCLLRNPLVLTQTFCQVTKSLTLKSSGY--FLPKFLQSH 393

  Fly   393 FHKDAQSATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCP 457
            |.....:|:|:.|...:.|.::|....|.::.:.:.|...||.:.::...||::..:...|..|.
  Rat   394 FLIVPTNASILTGMFVLPGALIGRFLGGYIVDRLQMSTKVVLKFMMVSSFISVVLFLLTFFWSCE 458

  Fly   458 NT-FS-----MTQAGQL-NLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYN--ATSK 513
            .. |:     ....|:| |.|:.||..|.|....|:.:|.. .:..:||||.||||...  ...|
  Rat   459 TAGFAGINDDYDGLGKLGNFTAPCNEYCGCTMTDYSTICGR-DEKQYFSACFAGCRASKPLRKEK 522

  Fly   514 LYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRR 578
            .|.:|||:                                  ..|:...||:|.|.|.:
  Rat   523 AYYNCSCI----------------------------------KEGLTAPDDDGQFFDAV------ 547

  Fly   579 STSDSVIRPGICTKNCNW--SFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALM 641
                    .|.|...|..  ..:||...:.:.|.|.|   |.:.::..::|.....|.:.|:...
  Rat   548 --------SGTCNTKCLTLPLLFAFYFAATVFSNFCS---VPSFMIVLKSVPASWNSMSLGVTYT 601

  Fly   642 MISLLALIPGPIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRY------------------- 686
            :...|..:|..::|....|.||..| ..:|...|.|.:|::....:
  Rat   602 IWRFLGSVPDHLLFESTSDYTCNFWDINSCGEKGRCWIYNKKNLLFTFQSTSDKHIEDIKLNKGI 666

  Fly   687 -----------SLNFLSCLLTFMGLL-FDYLVWYYGRNLDIYGDKEAKEEER 726
                       |:...:.||...|:. .||:|....::|.|: .|:.||:|:
  Rat   667 CDISARSQQGISMQISTGLLCLYGIYRHDYVVKEKNKSLPIH-VKDEKEKEK 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	147/682 (22%)
		MFS	40..>280	CDD:119392	54/260 (21%)
		DUF4064	364..447	CDD:290013	19/84 (23%)
		KAZAL_SLC21	470..521	CDD:238650	19/52 (37%)
Slco6d1	XP_017452073.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810