DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and SLCO4C1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_851322.3	Gene:	SLCO4C1 / 353189	HGNCID:	23612	Length:	724	Species:	Homo sapiens

Alignment Length:	782	Identity:	207/782 - (26%)
Similarity:	332/782 - (42%)	Gaps:	179/782 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PNRPP-----------------GHYLCGMANWHPPWLQKYATTKMFMGVYGLLGTIQAMSYMYFI 56
            |:.||                 |.|  |..|:||..||:..|...|:..|.||...|.:.....:
Human    64 PSAPPNVSEEKLRSLSLSEFEEGSY--GWRNFHPQCLQRCNTPGGFLLHYCLLAVTQGIVVNGLV 126

  Fly    57 -VTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRNRPRWIAWGIVFCGLSCYILVL 120
             ::::|:|||:::.|..||:|.|..:||..:|||.:|:.|.:.::|||:|:.....||...:..|
Human   127 NISISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSL 191

  Fly   121 PHFIYGAGHEVLQFTKEYQ-DSLLNGTTGSDHSFQNISSVKTERLCGVDKTEDDC----DDLFSY 180
            |.|          |:.||: .||...|                  |...:....|    ..|.:|
Human   192 PQF----------FSGEYKLGSLFEDT------------------CVTTRNSTSCTSSTSSLSNY 228

  Fly   181 VPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNT 245
              |.:..|.|.:||.|.|..|:||..:|||:.....:.|.:....|:.::||.:|:..|...|..
Human   229 --LYVFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTI 291

  Fly   246 FIDPT--KTPLIDSKDPRWLGAWWLG----WVILGTLMCLFSGLIGLFPKQLP---KVNASRTNS 301
            :||..  ::..:...|||||||||:|    |:...:|:..||    .|||.||   ::.|.:|
Human   292 YIDVAMGESTDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFS----CFPKHLPGTAEIQAGKT-- 350

  Fly   302 HLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADL---PKLKDFPRALMRLLRNKL 363
                                 |....||           :|||:   ..:||||.||..|::|.:
Human   351 ---------------------SQAHQSN-----------SNADVKFGKSIKDFPAALKNLMKNAV 383

  Fly   364 LIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVVGLIGSGMVLSKKKP 428
            .:..:||.....|..:||.|||.|::|.||...:..|..:.|.:.|.|..:|.|..|.::||.:.
Human   384 FMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRM 448

  Fly   429 SVSKVLMWNVIVGGISILGQISYAFLY--CPN------TFSMTQAGQL-NLTSNCNMNCSCEGIS 484
            :....:.:.:...|:::  .:|:.|:|  |.|      :.|....|:| ||.:.||.||:|....
Human   449 TCKNTMKFALFTSGVAL--TLSFVFMYAKCENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSY 511

  Fly   485 YTPVCHEPTDTTFFSACHAGCRG--YNATSKLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELD 547
            |.|||.:  ...:||.|.|||..  .:...|:|.:|||:.......|.|:
Human   512 YYPVCGD--GVQYFSPCFAGCSNPVAHRKPKVYYNCSCIERKTEITSTAE--------------- 559

  Fly   548 TTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGICTKNCNW--SFWAFSITSMIVSW 610
             |..|:                               .:.|.|..:|..  .|.......:|.::
Human   560 -TFGFE-------------------------------AKAGKCETHCAKLPIFLCIFFIVIIFTF 592

  Fly   611 FGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFGRLIDSTCLVW-TKTCNGNG 674
            ...:....::|   |.|.|..:|.|.|:..|::.||..||||||||..|||||::| ...|...|
Human   593 MAGTPITVSIL---RCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKG 654

  Fly   675 NCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYGRNLDIYGDKEAKEEERANRKDQPITPLLA 739
            .|.:||..:..:.|..:|.....:.:.|:      |..:.:|....:..:...::::..:|.:||
Human   655 ACWIYDNIKMAHMLVAISVTCKVITMFFN------GFAIFLYKPPPSATDVSFHKENAVVTNVLA 713

  Fly   740 KK 741
            ::
Human   714 EQ 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	187/679 (28%)
		MFS	40..>280	CDD:119392	73/251 (29%)
		DUF4064	364..447	CDD:290013	22/82 (27%)
		KAZAL_SLC21	470..521	CDD:238650	20/52 (38%)
SLCO4C1	NP_851322.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..71		3/6 (50%)
		OATP	106..664	CDD:281175	187/679 (28%)
		MFS	124..>485	CDD:119392	119/430 (28%)
		KAZAL_SLC21	499..549	CDD:238650	20/51 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810