DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and Oatp33Eb

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_609570.1	Gene:	Oatp33Eb / 34662	FlyBaseID:	FBgn0032435	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	774	Identity:	188/774 - (24%)
Similarity:	313/774 - (40%)	Gaps:	180/774 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NRPPGHYLCGM--ANW-HPPWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQ 71
            |.|.....||:  ..| ..|..||||..:.|:.|..:.||:|.....||.|:......:|.....
  Fly    19 NIPDDSVDCGIKGLGWCRGPGCQKYARLRTFILVLAISGTLQGACESYFRVSAKQASFQFGWNPL 83

  Fly    72 TTGIILSGNEISQIMLSLILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFT- 135
            ....:|..:.:.|.:.:|..:|.....:..:|:...::...::|.:.|:|        .::.|.
  Fly    84 IVDWLLVASGLFQAVFALAFAYWADVYHPIKWLVGTLMLQAVTCVVAVIP--------SIMNFAD 140

  Fly   136 -KEYQDSLL--NGTTGSDHSFQNISSVKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGN 197
             .:.:|:||  |....|...||.::..:.:.               |.:.|.::|:.|..||:|.
  Fly   141 GNQAKDALLDANMCATSLAQFQRLTLTEAQS---------------SSLTLAMLFVLQLALGMGG 190

  Fly   198 TLYYSLGQTYLDDNTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKTPLIDSKDPRW 262
            ..||:||.:|:|||:...::|.::..|:|.|:.|...|   .|:.|...:...
  Fly   191 LAYYTLGVSYIDDNSLSQDSPAVIGAALAARVFGQQAG---SFLVLGVGLTHV------------ 240

  Fly   263 LGAWWLGWVILGTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENL-SLSSRF 326
              .||||||||...:.:.:.|:|||||:|||.           .:.|..:.:..:.:: ...|:|
  Fly   241 --GWWLGWVILAPFIFVGAVLLGLFPKRLPKT-----------VIHQAAQRIIEQSSMRRFGSQF 292

  Fly   327 SSNAALDTIGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILS-------AVFYILGASGFM-- 382
            |:  .:|.              .||..:|.||..|:||:||:||       .|.|.|....::
  Fly   293 ST--YMDD--------------SDFWPSLKRLFNNRLLMFNLLSIMCVQSAVVNYGLQEESYLQS 341

  Fly   383 TFLTKYMEVQFHKDAQSAT--------IIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVI 439
            .|...|.|    :|..:|.        .:..|:..:||::    ||:|:||.|.|..|:...|:.
  Fly   342 RFFLPYNE----QDGLAAEWRSAFVSYFLKPPVMALGMLI----SGLVISKAKLSARKITGINIA 398

  Fly   440 VGGISILGQISYAFLYCP-NTFSMTQAGQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHA 503
            :....:...|...|:.|. ...:..:.|:|. ...|:..|.|...::.|||.|.:..|:||.|:|
  Fly   399 LSIHLVAIFIGLIFVQCDVGAIAGVEGGKLK-QPYCSSQCLCTPTAFMPVCPENSSVTYFSPCYA 462

  Fly   504 GCRGYNATS--KLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNG 566
            ||......:  :|:|.|||                                    ||
  Fly   463 GCTKKTTINSFQLFEGCSC------------------------------------SG-------- 483

  Fly   567 DFDDQLLSRT--RRSTSDSVIRPGICTK-NCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVA 628
               ||.|:.|  .|:|:      |.|:. ||..:...|.|.|:.|::....|.:|..|:..|||.
  Fly   484 ---DQSLNSTGQMRATA------GACSSDNCQSAIIIFQIMSISVAFLMGVGAIGKTLITLRAVL 539

  Fly   629 HEDKSFAQGLALMMISLLALIPGPIIFGRLIDSTCLVWTKTCNGNGNCQLYDQTRFRYSLNFLSC 693
            .:|||.|....||::.|.|.:|..:.:..:..:||:.|.....   .|.|.:..:....|:.|:.
  Fly   540 PQDKSLALAFELMIVGLFAYVPVHLSYDIVTRTTCVYWAPNYE---RCLLRETPKHGNILDILTA 601

  Fly   694 LLTFMGLLFDYLVWYYGRNLDIYGDK-----------------EAKEEERANRKDQPIT 735
            .|....:|||.||:.:.:.|::|..|                 :|.....|.|...|:|
  Fly   602 SLILASVLFDILVYIFAKGLNLYNCKVTDNNYTPSLYAPIPHEDATTSPSAPRGGSPVT 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	162/675 (24%)
		MFS	40..>280	CDD:119392	55/243 (23%)
		DUF4064	364..447	CDD:290013	25/99 (25%)
		KAZAL_SLC21	470..521	CDD:238650	18/52 (35%)
Oatp33Eb	NP_609570.1	oat	23..619	CDD:273279	178/727 (24%)
		MFS	50..>267	CDD:119392	61/256 (24%)
		KAZAL_SLC21	430..483	CDD:238650	19/88 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446206
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840