DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and slco1d1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001335015.1	Gene:	slco1d1 / 326845	ZFINID:	ZDB-GENE-030131-5044	Length:	689	Species:	Danio rerio

Alignment Length:	743	Identity:	190/743 - (25%)
Similarity:	327/743 - (44%)	Gaps:	127/743 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99
            |||:.....:...:|....|...::|.:|:||.:||...|.|....||..:.:...:||.|.:.:
Zfish    15 KMFLAAMCFVFFAKAFQGSYMKSSVTQIERRFDVPSSLIGFIDGSFEIGNLFVIAFVSYFGAKLH 79

  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSL------LNGTTGSDHSFQNISS 158
            |||.||.|.:......:|..:|||..|      |:  :|:.::      :|||........|.|.
Zfish    80 RPRLIAAGCLVMSAGSFITAMPHFFQG------QY--KYESTISHFSASVNGTENVLPCLTNASL 136

  Fly   159 VKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAV 223
            .:...:..|: ::.:|:...|....:.:||...:.|:|.|....||.:||||.:::.||...||:
Zfish   137 AQDSEIPTVE-SQAECEKASSSSLWLFVFLGNMLRGIGETPVMPLGLSYLDDFSREENTAFYLAL 200

  Fly   224 AMALRMIGPVVGFFFGFISLNTFIDPTKTPL----IDSKDPRWLGAWWLGWVILGTLMCLFSGLI 284
            ...:.::||:.||..|......::|.....|    |:.||.||:||||||:::.|.:|.|.....
Zfish   201 IQTVGIMGPMFGFMLGSFCAKLYVDIGTVDLDSITINYKDSRWVGAWWLGFLVTGGVMLLAGIPF 265

  Fly   285 GLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPKLK 349
            ...||.|.:.....:... |.|....::|....:|...:...|..|.: |:.|.|         |
Zfish   266 WFLPKSLTRQGEPESEKK-PGAPEGGEQERFIPDNNKHNPPASKPAPV-TMSALA---------K 319

  Fly   350 DFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVV 414
            ||..:|.:|..|.:.:..:.:.:..:.|..|.:||..|:||..:.:.|..|..::|.:::..:.:
Zfish   320 DFLPSLKKLFSNTIYVLLVCTGLIQVSGFIGMITFKPKFMEQVYGQSASRAIFLIGIMNLPAVAL 384

  Fly   415 GLIGSGMVLSKKKPSV---SKVLMWNVIVGGISILGQISYAFLYCPNT----FSMTQAG------ 466
            |::..|.::.:.|.:|   :|:.:...::...|:|  |.| ||.|.|:    .::|..|
Zfish   385 GIVTGGFIMKRFKVNVLGAAKICIVASVLAFCSML--IQY-FLQCDNSQVAGLTVTYQGAPEVSY 446

  Fly   467 -QLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSK--LYEDCSCVVNDPAPK 528
             ...|.|.||:.|||....:.|:| .....|:.|.|.|||:......|  ::.:|||:
Zfish   447 QTETLISQCNIGCSCSLKHWDPIC-ASNGVTYTSPCLAGCQTSTGIGKEMVFHNCSCI------- 503

  Fly   529 SAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGICTK- 592
                                                    .:.||..|..|   :|:  |.|.:
Zfish   504 ----------------------------------------GEALLPYTNMS---AVL--GQCPRK 523

  Fly   593 -NCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFG 656
             :|::.|..:...::|.::|.:.|.....::..|::..|.||.|.|:..:::..|..||.||.||
Zfish   524 SDCDFMFKIYMAVTVIGAFFSAVGATPGYIILLRSITPELKSLALGMHTLIVRTLGGIPPPIYFG 588

  Fly   657 RLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYGRNLDIYG--- 717
            .|||.|||.| .|.|.|.|.|::||...||.:         |:||::.    .|..:..::|
Zfish   589 ALIDKTCLKWGLKQCGGRGACRIYDSGAFRNA---------FLGLIYA----LYSSSYLLFGLLY 640

  Fly   718 DKEAKEEERANRKDQPITPLLAKKSEQE 745
            ::.:..|::...|||      .|..||:
Zfish   641 NRLSHREKKQALKDQ------LKAPEQD 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	175/676 (26%)
		MFS	40..>280	CDD:119392	71/249 (29%)
		DUF4064	364..447	CDD:290013	16/85 (19%)
		KAZAL_SLC21	470..521	CDD:238650	18/52 (35%)
slco1d1	NP_001335015.1	OATP	16..617	CDD:308646	175/676 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920