Protein Alignment Oatp33Ea and Slco5a1

DIOPT Version :10

• Sequence 1: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_001423667.1
• Gene: Slco5a1 / 312907
• RGDID: 1307132
• Length: 850
• Species: Rattus norvegicus
• Alignment Length: 789
• Identity: 206/789 - (26%)
• Similarity: 346/789 - (43%)
• Gaps: 169/789 - (21%)

  Fly     6 RRDPNRPPGHYLCGMANWHPPWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVT------------ 58
            ||||::.                         :.|...|.|:|....:|.::|
  Rat   101 RRDPSKT-------------------------VSVSSTLATLQERRCLYVVLTDSRCFLVCMCFL 140

  Fly    59 ---------------LTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRNRPRWIAWGI 108
                           :||:|:|:.:.|..:|:::|..:|..:::.:.:||.||:..||.|:|.|.
  Rat   141 TFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGG 205

  Fly   109 VFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISS--VKTERLCGVDKTE 171
            :...:...:..|||||          :..||...||.:..:|...||.:|  :.....|..|...
  Rat   206 LLIAIGAALFALPHFI----------SPPYQIQELNASASNDGLCQNGNSTAILEPPPCPKDSGG 260

  Fly   172 DDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAMALRMIGPVVGF 236
            :.     .::.:.|...:|.::|:|:|..|:||.||||||.||.|..|.||:...:..:||.||:
  Rat   261 NS-----HWIYVALFVCAQVLIGMGSTPIYTLGPTYLDDNVKKDNASLYLAIMYVMGALGPAVGY 320

  Fly   237 FFGFISLNTFIDPTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSGLIGLFPKQLPKVNASRTNS 301
            ..|.:.:..::||....|:|..|||::|.||.|:::....|.|....:..|||:||..:..:...
  Rat   321 LLGGLLIGFYVDPRNPVLLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKKF 385

  Fly   302 HLPLA----LRQTKEELKREENLSLSSR-FSSNAALDTIGAAAGANADLPKLKDFPRALMRLLRN 361
            ...:.    :.:.|.....:.|..:||. |..|                  ::|.|||.:|:|.|
  Rat   386 SADVVSDDDIIKEKSNTSEQVNKKVSSMGFGKN------------------VRDLPRAAVRILSN 432

  Fly   362 KLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVVGLIGSGMVLSKK 426
            ...:|..||........:.|:||:.|::|.||...|.:|:|..|.|.:....||::..|.::.|.
  Rat   433 MTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKL 497

  Fly   427 KPSVSKVLMWNVIVGGISI---------------LGQISYAFLYCPNTFSMTQAGQLNLTSNCNM 476
            |....:.....:|..|:|:               ||.|:..:...|   |:|...: |||.:||:
  Rat   498 KLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINIPYTTGP---SLTMPHR-NLTGSCNV 558

  Fly   477 NCSCEGISYTPVCHEPTDTTFFSACHAGC-RGYNATS--KLYEDCSC-----VVNDPAPKSAAQR 533
            ||.|:...|.|||.. ...|:|:.|.||| ...|.|:  :.|.:|:|     |:..|.....:|.
  Rat   559 NCGCKIHEYEPVCGS-DGITYFNPCLAGCINSGNLTTGVRNYTECTCVQSRQVITPPTVGQRSQL 622

  Fly   534 LLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGICTKNCNWSF 598
            .:.:::          ||          |::||                 ....|.|.:.|| :.
  Rat   623 RVVIVK----------TY----------LNENG-----------------YAVSGKCKRACN-TL 649

  Fly   599 WAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFGRLIDSTC 663
            ..|.:...||::..:..:...::|..|:|..|::.||.|:..:::..||.||.||.||.:||:||
  Rat   650 IPFLVFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTC 714

  Fly   664 LVWTKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYGRNLDIYGDKEAKEEERAN 728
            ::|.:.|...|:|..|:.|.||:....|:..|.|:|.:|.:|.||         ..:.||:|...
  Rat   715 MLWQQECGVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAWY---------SIKYKEDELQR 770

  Fly   729 R--KDQPIT 735
            |  :|.|::
  Rat   771 RRCRDFPLS 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	186/704 (26%)
Slco5a1	NP_001423667.1	MFS_SLCO5_OATP5	131..676	CDD:340962	156/620 (25%)