DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Ea and Slco6c1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_775460.1	Gene:	Slco6c1 / 287006	RGDID:	708431	Length:	701	Species:	Rattus norvegicus

Alignment Length:	761	Identity:	167/761 - (21%)
Similarity:	286/761 - (37%)	Gaps:	181/761 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PWLQKYATTKMFM-------GVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEIS 83
            |.||::.....||       .::|.|..:..| .:....:|.||.||.......:|.|:|.
  Rat    78 PCLQRFNNIDCFMIFFIASVLIHGALFALADM-ILNLYHSLLTLSKRELYFMDFSGYIVSS---- 137

  Fly    84 QIMLSLILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIY----GAGHEVLQFTKEYQDSLLN 144
              ::::.:::.||:.||.:|||...:.......:|..|...|    ..|..|....:|.:...::
  Rat   138 --LVAIFVAHFGGKGNRTKWIAAACILMAFGSILLGFPFSKYEIMKSGGQRVELCVEENKRRNIH 200

  Fly   145 GTTGSDHSFQNISSVKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLD 209
            ..|.|:                .|:|:..|          ...:.|.:.|:.....|.||:|::.
  Rat   201 CVTNSN----------------PDRTKCIC----------FFIIGQCLNGIAGMPIYILGKTFIL 239

  Fly   210 DNTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKTPL--IDSKDPRWL--GAWWLGW 270
            |:....:....||:..:..::|..:|.|.|..:|:   .|.|..|  :||.....|  ..||..:
  Rat   240 DHVPTRSAGFYLALGHSAHLMGYFLGIFGGMKNLS---PPPKEKLSAVDSAKIHLLLQFGWWKTF 301

  Fly   271 VILGTLMCLFSGLIGL--FPKQLPKVNASRTNSH-LPLALRQTKEELKREENLSLSSRFSSNAAL 332
            :.:..:.  ||..:.|  ||..||       .:| |.||        ||:|..:...|......
  Rat   302 LFVAAIS--FSVFLVLLCFPTSLP-------GAHKLKLA--------KRKEPPTFDKRLKDQKI- 348

  Fly   333 DTIGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDA 397
                        .|:.|.|..|:..:|||.||:...:..|.........:.||..:::.||....
  Rat   349 ------------QPRFKGFVFAIWYMLRNPLLMTQAMCKVSESFAFHTSLEFLPYHLQTQFSITP 401

  Fly   398 QSATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNT-FS 461
            |.|:::.|...|.|.|:|....|:::.:.:.:....|.::::...:|:...:...|:.|..| |:
  Rat   402 QIASMLTGLFVIPGGVIGHFLGGLIVDRLEMTNKNKLKFSLVTSVVSVALFLLIFFVECETTKFA 466

  Fly   462 -----MTQAGQL-NLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNAT-----SKLY 515
                 ....|:| |||:.||.:|:|....|:.||.. .:..:||.|.|||   :||     .|.|
  Rat   467 GINEDYDGLGKLGNLTAGCNYHCACTTSLYSSVCGR-DEKEYFSPCFAGC---SATKVQQNEKTY 527

  Fly   516 EDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRST 580
            .:|||:                                  ..|:...|.:|.|.|         .
  Rat   528 YNCSCI----------------------------------KEGLTTSDADGHFID---------A 549

  Fly   581 SDSVIRPGICTKNCNW--SFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMI 643
            :|     |.|..||..  .|:||..::.:.|...|:   ..:|:..::|.....|..||:.:.:.
  Rat   550 TD-----GTCNSNCLTLPLFFAFYFSATVFSTMCST---PIILIILQSVPANFSSLGQGVTVAIT 606

  Fly   644 SLLALIPGPIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRY-------SLNFLSCLLTFMGL 700
            ...|.:|.|.:||......|..| ...|.....|.:|::|...|       |....:.||....:
  Rat   607 KFTASVPEPALFGTASSVACKFWDINACGVREKCWIYNKTTLVYVFIGIWVSFKLFTALLNIYAI 671

  Fly   701 -LFDYLVWYYGRNLDIYGDKEAKEEERANRKDQPITPLLAKKSEQE 745
             ::||:|                   :....|...|.:.|.|:::|
  Rat   672 HIYDYVV-------------------KGKISDSKTTHVKASKAQKE 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	152/680 (22%)
		MFS	40..>280	CDD:119392	51/247 (21%)
		DUF4064	364..447	CDD:290013	16/82 (20%)
		KAZAL_SLC21	470..521	CDD:238650	21/55 (38%)
Slco6c1	NP_775460.1	OATP	88..648	CDD:281175	152/680 (22%)
		MFS	90..>457	CDD:119392	91/432 (21%)
		KAZAL_SLC21	481..534	CDD:238650	22/90 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810