DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and Slco1b2

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_065241.1	Gene:	Slco1b2 / 28253	MGIID:	1351899	Length:	689	Species:	Mus musculus

Alignment Length:	747	Identity:	178/747 - (23%)
Similarity:	304/747 - (40%)	Gaps:	139/747 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 IQAMSYMYFIVTL---------TTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRNRPR 102
            :.|:|:.|....|         |.:|:||.|||..:|:|..|.||..:::.:.:||.|.:.:||:
Mouse    29 LAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPK 93

  Fly   103 WIAWGIVFCGLSCYILVLPHFI-----YGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVKTE 162
            .|..|....|:...:..||||.     |...:::..........|:|.||       :::....|
Mouse    94 LIGTGCFIMGIGSILTALPHFFMGYYRYATENDISSLHNSTLTCLVNQTT-------SLTGTSPE 151

  Fly   163 RLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAMAL 227
            .:      |..|:...:....:.:.:...:.|:|.|....||.:|:||..|:.|:.:.|.....:
Mouse   152 IM------EKGCEKGSNSYTWIYVLMGNMLRGIGETPIVPLGVSYIDDFAKEGNSSMYLGTLHTI 210

  Fly   228 RMIGPVVGFFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSGLIGLFP 288
            .||||::||....:....::|    ..::..|..:|.||:||||||:::.| |:|:...:...|.
Mouse   211 AMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNG-LLCIICSIPFFFL 274

  Fly   289 KQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPKLKDFPR 353
            .::||.:.....:...|.:.:|.|:.....|.:...:            .|.||     |..|..
Mouse   275 PKIPKRSQKERKNSASLHVLKTDEDKNPVTNPTTQEK------------QAPAN-----LTGFLW 322

  Fly   354 ALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVVGLIG 418
            :|..:|.|:..:..::..:..|....|..|:|.|::|.||.:.|..|..::|.|:|..|..|:..
Mouse   323 SLRSILTNEQYVIFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFL 387

  Fly   419 SGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNT----FSMTQAGQLNLTSN------ 473
            .|.::.:.|.::..:..:......::.:..:||..|.|.|.    .::|..|...:.|:
Mouse   388 GGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLICENKAFAGLTLTYDGMNPVDSHIDVPLS 452

  Fly   474 -CNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSKL----YEDCSCVVNDPAPKSAAQR 533
             ||.:|.|:...:.|||.| ...|:.|.|.|||:.:....||    :.|||||
Mouse   453 YCNSDCICDKNQWEPVCGE-NGVTYISPCLAGCKSFRGDKKLMNIEFYDCSCV------------ 504

  Fly   534 LLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGICTKN-CNWS 597
                                   ||......|..                 .|.|.|.:: |...
Mouse   505 -----------------------SGSGFQKGNHS-----------------ARLGECPRDKCKTK 529

  Fly   598 FWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFGRLIDST 662
            ::.:....:|:|:|.:.|....:|:..|:|..|.||...|...:::..|..|..|:.:|.|||.|
Mouse   530 YYFYITFQVIISFFTALGSTSLMLILIRSVQPELKSLGMGFHSLVVRTLGGILAPVYYGALIDRT 594

  Fly   663 CLVWTKT-CNGNGNCQLYDQTRFRYSLNFLS------CLLTFMGLLF---------DYLVWYYGR 711
            |:.|:.| |...|.|:||:...|......||      .||.::.|::         |..:...||
Mouse   595 CMKWSVTSCGARGACRLYNSRLFGMIYVGLSIALKTPILLLYVALIYVMKRKMKRNDNKILENGR 659

  Fly   712 NLDIYGDKEAKEEERANRKDQPITPLLAKKSE 743
            .....|:.|.     .|.......|...|.||
Mouse   660 KFTDEGNPEP-----VNNNGYSCVPSDEKNSE 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	162/671 (24%)
		MFS	40..>280	CDD:119392	67/250 (27%)
		DUF4064	364..447	CDD:290013	17/82 (21%)
		KAZAL_SLC21	470..521	CDD:238650	20/61 (33%)
Slco1b2	NP_065241.1	MFS	26..557	CDD:421695	140/611 (23%)
Slco1b2	NP_065241.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..689		9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820