DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and Slco1a1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_038825.1	Gene:	Slco1a1 / 28248	MGIID:	1351891	Length:	670	Species:	Mus musculus

Alignment Length:	745	Identity:	192/745 - (25%)
Similarity:	315/745 - (42%)	Gaps:	142/745 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIG 95
            ::..|:|:.........:::|.:|....||.:|::|.||:...|.|....||..::|.:.:||.|
Mouse    16 FSKMKVFLMSLTCAYLAKSLSGVYMNSMLTQIERQFGIPTSVVGFITGSFEIGNLLLIVFVSYFG 80

  Fly    96 GQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVK 160
            .:.:||..|..|.|..||.|:::..|||:.|        ..:|:.::...:..|.:||..|.: :
Mouse    81 RKLHRPIIIGVGCVVMGLGCFLMASPHFLMG--------RYKYETTISPTSNLSSNSFLCIEN-R 136

  Fly   161 TERLCGVDKTED--DCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAV 223
            |:.|   ..|:|  :|......:..:.:.:...:.|:|.|....||.:|::|..|..|:||.:.:
Mouse   137 TQTL---KPTQDPTECVKEIKSLMWIYVLIGNTMRGIGETPIMPLGISYIEDFAKSENSPLYIGI 198

  Fly   224 AMALRMIGPVVGFFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSGLI 284
            ....:::||::|...|......::|    .|....|...|.||:||||:|:::...:..|.|...
Mouse   199 LEMGKIVGPIIGLLLGSFFARVYVDIGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPF 263

  Fly   285 GLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPKLK 349
            ..|||.|||...............:...|..::|||.::                         |
Mouse   264 FFFPKTLPKKELQDNVDVTKYEKVEKHRERAKKENLGIT-------------------------K 303

  Fly   350 DFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVV 414
            ||...:..|..|.:.:...|::|..|.|.:...|||.||:|.|:.|....|..::|..|:..:.:
Mouse   304 DFLPFMKSLCCNPIYMLFSLTSVLQINGFASTFTFLPKYLEQQYGKSTSEAVFLIGVYSLPPVCL 368

  Fly   415 GLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLY-------CPN--TFSMTQA----- 465
            |.:.||.::.|.|.:|.|..   .|..|:|    :|..|::       |.|  ...:|.:
Mouse   369 GYLISGFIMKKFKITVKKAA---YIAFGLS----LSEYFIFLCNYLLTCDNFPVAGLTTSYKGVQ 426

  Fly   466 ----GQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGY--NATSKLYEDCSCVVND 524
                |:.|:.::||..|||...::.|||.: ....:.|||.|||...  ..|:.::::|||:.:
Mouse   427 HPLYGEKNVLADCNTRCSCLTDTWDPVCGD-NGLAYMSACLAGCEKSVGTGTNMVFQNCSCIGS- 489

  Fly   525 PAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGI 589
                                            ||                     .|.:|:  |:
Mouse   490 --------------------------------SG---------------------NSSAVL--GL 499

  Fly   590 CTK--NCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGP 652
            |.|  .|:.....|.|.|:..|:..|...:...:|..|.|..|:||...||....|.|||.||.|
Mouse   500 CKKGPECDNKLQYFLIKSVFSSFIFSLAAIPGYMVLLRCVKSEEKSIGVGLHAFFIRLLAGIPAP 564

  Fly   653 IIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLL---TFMGLLFDYLVWYYGRNL 713
            :.||.|||.|||.| |..|...|.|::||..|||:....|...:   :|:..:|..::.   |..
Mouse   565 VYFGALIDRTCLHWGTLKCGQPGACRMYDINRFRHIYLGLPAAVRGSSFLPAVFILILM---RKF 626

  Fly   714 DIYGDKEAKEEERANRKDQPITPLLAKKSE 743
            ...||..:.:.|.|..|      |..|:||
Mouse   627 HFPGDIHSPDTELAEMK------LTEKESE 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	175/676 (26%)
		MFS	40..>280	CDD:119392	64/245 (26%)
		DUF4064	364..447	CDD:290013	25/82 (30%)
		KAZAL_SLC21	470..521	CDD:238650	17/52 (33%)
Slco1a1	NP_038825.1	oat	1..625	CDD:273279	182/712 (26%)
		MFS	23..>396	CDD:119392	106/416 (25%)
		KAZAL_SLC21	436..488	CDD:238650	18/52 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820