DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and SLCO1B3

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_062818.1	Gene:	SLCO1B3 / 28234	HGNCID:	10961	Length:	702	Species:	Homo sapiens

Alignment Length:	725	Identity:	188/725 - (25%)
Similarity:	314/725 - (43%)	Gaps:	122/725 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99
            |||:.........:|:..:...:::|.:|:||.|.|...|:|....||..:::.:.:||.|.:.:
Human    28 KMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLH 92

  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVKTERL 164
            ||:.|..|.:..|....:..||||..|    ..:::||         |..:.|..:.||:.|
Human    93 RPKLIGIGCLLMGTGSILTSLPHFFMG----YYRYSKE---------THINPSENSTSSLST--- 141

  Fly   165 CGVDKT-----------EDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTP 218
            |.:::|           |.||.........:.:|:...:.|:|.|....||.:|:||..|:.::.
Human   142 CLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSS 206

  Fly   219 LMLAVAMALRMIGPVVGFFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVILGTLMCL 279
            |.|....|:.|||||:||..|.:....::|    ...|..|..||.||:||||||:::.| |..:
Human   207 LYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSG-LFSI 270

  Fly   280 FSGLIGLFPKQLPK-VNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANA 343
            .|.:...|   ||| .|..:....:.|:|...|....|.:..:|::: ..|...:..|
Human   271 ISSIPFFF---LPKNPNKPQKERKISLSLHVLKTNDDRNQTANLTNQ-GKNVTKNVTG------- 324

  Fly   344 DLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPIS 408
                   |.::|..:|.|.|.:..:|..:..:....|..|::.||||.|:.:.|..|..::|.|:
Human   325 -------FFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIIT 382

  Fly   409 IMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNT----FSMTQAGQLN 469
            |..:..|:...|.::.|.|.|:..:..::.:...||.|.|:.|..|.|.:.    .::|..|..:
Human   383 IPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLICESKSVAGLTLTYDGNNS 447

  Fly   470 LTSN-------CNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSK--LYEDCSCVVNDP 525
            :.|:       ||..|:|:...:.|||.. ...|:.|.|.|||:..:...|  ::.:||||
Human   448 VASHVDVPLSYCNSECNCDESQWEPVCGN-NGITYLSPCLAGCKSSSGIKKHTVFYNCSCV---- 507

  Fly   526 APKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGIC 590
                                         .::|:    .|.::...|               |.|
Human   508 -----------------------------EVTGL----QNRNYSAHL---------------GEC 524

  Fly   591 TKN--CNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPI 653
            .::  |...|:.:....:|.|.|.::|....:|:..:.|..|.|:.|.|...|:|..|..|..||
Human   525 PRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPI 589

  Fly   654 IFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYGRNLDIYG 717
            .||.|||.||:.| |.:|...|.|::|:...|......||..|.|..|:. |:|:.:.......|
Human   590 YFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVL-YIVFIFAMKKKFQG 653

  Fly   718 -DKEAKEEER 726
             |.:|.:.||
Human   654 KDTKASDNER 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	174/679 (26%)
		MFS	40..>280	CDD:119392	72/254 (28%)
		DUF4064	364..447	CDD:290013	20/82 (24%)
		KAZAL_SLC21	470..521	CDD:238650	17/59 (29%)
SLCO1B3	NP_062818.1	OATP	29..621	CDD:281175	174/679 (26%)
		MFS	31..>429	CDD:119392	113/432 (26%)
		KAZAL_SLC21	455..508	CDD:238650	18/86 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920