Protein Alignment Oatp33Ea and SLCO3A1

DIOPT Version :10

• Sequence 1: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_037404.2
• Gene: SLCO3A1 / 28232
• HGNCID: 10952
• Length: 710
• Species: Homo sapiens
• Alignment Length: 691
• Identity: 191/691 - (27%)
• Similarity: 290/691 - (41%)
• Gaps: 136/691 - (19%)

  Fly    45 GTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRNRPRWIAWGIV 109
            ||:.|    |.:..|||||:||.:.|...|:|.|..||..:.|.|.:||.|.:.:|||.|..|.:
Human    54 GTVGA----YLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGI 114

  Fly   110 FCGLSCYILVLPHFI-----YGAGHEVLQFTKEYQD-SLLNGTTGSDHSFQNISSVKTERLCGVD 168
            ...|...:..||.|:     |.||.  :::..|.:| ...||:.|.:               |.|
Human   115 VMALGALLSALPEFLTHQYKYEAGE--IRWGAEGRDVCAANGSGGDE---------------GPD 162

  Fly   169 KTEDDCDDLF------SYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAMAL 227
                  .||.      :.:..:|:..:|.:||:|.|....||.:|:||:.::.::.|.:.:...:
Human   163 ------PDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTM 221

  Fly   228 RMIGPVVGFFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSGLIGLFP 288
            .:.||..||..|......::|    .|....|...||||:||||.|:::.|.|:...|.|:..||
Human   222 LVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFP 286

  Fly   289 KQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSR-----FSSNAALDTIGAAAGANADLPKL 348
            :.||        .|        .|.....|...||.|     ..||..|........:.:...:|
Human   287 QSLP--------PH--------SEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQL 335

  Fly   349 KDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMV 413
            :..|:....||.|.:....||:|...|...:||..||.||:|.||:....||..::|..:|....
Human   336 RVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCAC 400

  Fly   414 VGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYC----------PNTFSMTQAGQL 468
            :|:...|:::.|...|....:...::|..:|....:|:.||.|          |...|......|
Human   401 LGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSAL 465

  Fly   469 NLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSKLYEDCSCVVNDPAPKSAAQR 533
            :..|.||.||.|:..|:|||| .....|:.|||.|||...|.|.     |:|:...||
Human   466 DPYSPCNNNCECQTDSFTPVC-GADGITYLSACFAGCNSTNLTG-----CACLTTVPA------- 517

  Fly   534 LLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGIC-TKNCNWS 597
                                                           .::.:.||.| :..|..:
Human   518 -----------------------------------------------ENATVVPGKCPSPGCQEA 535

  Fly   598 FWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFGRLIDST 662
            |..|.....|.|..|:..:..:|::..|.|:.|.||:|.|:..:::.||..||.|:|||..||||
Human   536 FLTFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDST 600

  Fly   663 CLVWTKTCNGNGNCQLYDQTRFRY-SLNFLSCLLTFMGLLF 702
            ||.|:..|...|.|.|||...:|| .::....|.:|..:|:
Human   601 CLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILY 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	186/670 (28%)
SLCO3A1	NP_037404.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		MFS_SLCO3_OATP3	39..563	CDD:340960	158/611 (26%)