DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and Slco2a1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_073158.2	Gene:	Slco2a1 / 24546	RGDID:	3051	Length:	644	Species:	Rattus norvegicus

Alignment Length:	730	Identity:	192/730 - (26%)
Similarity:	309/730 - (42%)	Gaps:	174/730 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIG 95
            ::..|:|:..:|||...|.:...||..:|||:||||.:.|.::|:|.|.||||...|.:.:||.|
  Rat    28 FSNIKVFVLCHGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNATLIIFISYFG 92

  Fly    96 GQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVK 160
            .:.||||.|..|.:......::|.||||:    .|..|:|        :.|.|:..|||.
  Rat    93 SRVNRPRMIGIGGLLLAAGAFVLTLPHFL----SEPYQYT--------STTDGNRSSFQT----- 140

  Fly   161 TERLC--------------GVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDN 211
              .||              .|..|..:...|:.     |:.::|.:.|:|.......|.:|:||.
  Rat   141 --DLCQKHLPALPPSKCHSTVPDTHKETSSLWG-----LMVVAQLLAGIGTVPIQPFGISYVDDF 198

  Fly   212 TKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVI 272
            .:.||:||.:::..|:.:.||..|:..|.:.|..|:|    .|.|..:...||||:||||||.:|
  Rat   199 AEPTNSPLYISILFAIAVFGPAFGYLLGSVMLRIFVDYGRVDTATVNLSPGDPRWIGAWWLGLLI 263

  Fly   273 LGTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGA 337
            ....:.:.|.....||:.:.: .|.|:.:        .:|.:|.||:.|..|      .:|.|
  Rat   264 SSGFLIVTSLPFFFFPRAMSR-GAERSVT--------AEETMKTEEDKSRGS------LMDFI-- 311

  Fly   338 AAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATI 402
                       |.|||..:|||.|.|.:..:||...:....:|..|||.|::|.|:...|..|..
  Rat   312 -----------KRFPRIFLRLLMNPLFMLVVLSQCTFSSVIAGLSTFLNKFLEKQYGATAAYANF 365

  Fly   403 IVGPISIMGMVVGLIGSGMVLSK------KKPSVSKVLMWNVIVGGISILGQISYAFLYC----- 456
            ::|.:::....:|::..|:::.:      ..|.|:..::      .||::..:...|:.|
  Rat   366 LIGAVNLPAAALGMLFGGILMKRFVFPLQTIPRVAATII------TISMILCVPLFFMGCSTSAV 424

  Fly   457 -----PNTFSMTQAGQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSK--- 513
                 |:|.|.....|   ...|..:|||....:.|||.: ....:.|.|||||...|.:|:
  Rat   425 AEVYPPSTSSSIHPQQ---PPACRRDCSCPDSFFHPVCGD-NGVEYVSPCHAGCSSTNTSSEASK 485

  Fly   514 --LYEDCSCVVNDPA-------PKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFD 569
              :|.:||||....|       |.|.||.||        |.:    :...:.:.:..:..|
  Rat   486 EPIYLNCSCVSGGSASAKTGSCPTSCAQLLL--------PSI----FLISFAALIACISHN---- 534

  Fly   570 DQLLSRTRRSTSDSVIRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSF 634
                                            .:..|::                |.|..::|||
  Rat   535 --------------------------------PLYMMVL----------------RVVNQDEKSF 551

  Fly   635 AQGLALMMISLLALIPGPIIFGRLIDSTCLVWTKTCNG-NGNCQLYDQTRFRYSLNFLSCLLTFM 698
            |.|:..:::.|||.:|.|.::|.||||:|:.|...|:| .|.|..||....|.....|..:...:
  Rat   552 AIGVQFLLMRLLAWLPAPSLYGLLIDSSCVRWNYLCSGRRGACAYYDNDALRNRYLGLQMVYKAL 616

  Fly   699 G-LLFDYLVWYYGRN 712
            | ||..::.|...:|
  Rat   617 GTLLLFFISWRMKKN 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	184/694 (27%)
		MFS	40..>280	CDD:119392	82/257 (32%)
		DUF4064	364..447	CDD:290013	18/88 (20%)
		KAZAL_SLC21	470..521	CDD:238650	18/55 (33%)
Slco2a1	NP_073158.2	oat	1..630	CDD:273279	191/727 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		MFS	<166..>425	CDD:119392	76/297 (26%)
		KAZAL_SLC21	442..496	CDD:238650	19/54 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339162
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750