DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and Slco5a1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_766429.2	Gene:	Slco5a1 / 240726	MGIID:	2443431	Length:	850	Species:	Mus musculus

Alignment Length:	701	Identity:	196/701 - (27%)
Similarity:	330/701 - (47%)	Gaps:	97/701 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TKMFMGVYGLLGTIQAMSYM-YFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQ 97
            ::.|:.....|..|||:... |....:||:|:|:.:.|..:|:::|..:|..:::.:.:||.||:
Mouse   130 SRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGR 194

  Fly    98 RNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISS--VK 160
            ..||.|:|.|.:...:...:..|||||          :..||...||.:..:|...||.:|  :.
Mouse   195 GRRPLWLAVGGLLIAIGAALFALPHFI----------SPPYQIQELNASASNDGLCQNGNSTAIL 249

  Fly   161 TERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAM 225
            ....|..|...:.     .::.:.|...:|.::|:|:|..|:||.||||||.||.|..|.||:..
Mouse   250 EPPPCPKDSGGNS-----HWIYVALFVCAQVLIGMGSTPIYTLGPTYLDDNVKKDNASLYLAIMY 309

  Fly   226 ALRMIGPVVGFFFGFISLNTFIDPTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSGLIGLFPKQ 290
            .:..:||.||:..|.:.:..::||.....:|..|||::|.||.|:::....|.|....:..|||:
Mouse   310 VMGALGPAVGYLLGGLLIGFYVDPRNPVHLDQSDPRFIGNWWSGFLLCAIAMFLVIFPMFTFPKK 374

  Fly   291 LPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPKLKDFPRAL 355
            ||..:..:......:.:  ..:.:|.:.|.|    ...|..:..:|  .|.|     ::|.|||.
Mouse   375 LPPRHKKKKKFSADVVI--DDDIIKEKSNTS----EQMNKKVSPMG--FGKN-----VRDLPRAA 426

  Fly   356 MRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVVGLIGSG 420
            :|:|.|...:|..||........:.|:||:.|::|.||...|.:|:|..|.|.:....||::..|
Mouse   427 VRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGG 491

  Fly   421 MVLSKKKPSVSKVLMWNVIVGGISI---------------LGQISYAFLYCPNTFSMTQAGQLNL 470
            .::.|.|....:.....:|..|:|:               ||.|:..:...|   |:|...: ||
Mouse   492 YIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINIPYTTGP---SLTMPHR-NL 552

  Fly   471 TSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGC-RGYNATS--KLYEDCSC-----VVNDPAP 527
            |.:||:||.|:...|.|||.. ...|:|:.|.||| ...|.|:  :.|.:|:|     |:..|..
Mouse   553 TGSCNVNCGCKIHEYEPVCGS-DGITYFNPCLAGCINSGNLTTGVRNYTECTCVQSRQVITPPTV 616

  Fly   528 KSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGICTK 592
            ...:|..:.:::          ||          |::||                 ....|.|.:
Mouse   617 GQRSQLRVVIVK----------TY----------LNENG-----------------YAVSGKCKR 644

  Fly   593 NCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFGR 657
            .|| :...|.:...||::..:..:...::|..|:|..|::.||.|:..:::..||.||.||.||.
Mouse   645 TCN-TLIPFLVFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGA 708

  Fly   658 LIDSTCLVWTKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWY 708
            :||:||::|.:.|...|:|..|:.|.||:....|:..|.|:|.:|.:|.||
Mouse   709 VIDTTCMLWQQECGVQGSCWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAWY 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	186/673 (28%)
		MFS	40..>280	CDD:119392	73/242 (30%)
		DUF4064	364..447	CDD:290013	23/97 (24%)
		KAZAL_SLC21	470..521	CDD:238650	22/58 (38%)
Slco5a1	NP_766429.2	MFS_SLCO5_OATP5	131..676	CDD:340962	162/615 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6283
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760